Results 261 to 270 of about 481,952 (302)
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Intensification of ciliary motility by extracellular ATP
Biorheology, 1988Ciliary metachronism and motility were examined optically in tissue cultures from frog palate e:Rithelium as. a func.tion of extracellular ATP concentration in the range of 10−7–10−3M. The main findings were: a) upon addition of ATP the metachronal wavelength increased by a factor of up to 2.
D, Ovadyahu, D, Eshel, Z, Priel
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Modulation of myocardial activity by extracellular ATP
Trends in Cardiovascular Medicine, 1994Extracellular ATP, at micromolar concentration, induces multiple functional changes in cardiac cells. Stimulation of P(2) purinoceptors is associated with Ca current increase and positive inotropic effect. On rapid application, ATP triggers membrane depolarization by activating a Cl conductance and by inducing an acidification following Cl-HCO(3 ...
G, Vassort, M, Pucéat, F, Scamps
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Homocysteine modifies extracellular ATP availability in macrophages
Toxicology in Vitro, 2013Increased levels of plasma homocysteine (hyperhomocysteinemia-HHcy) are associated to the development of coronary artery disease (CAD), peripheral vascular disease and thrombosis. In addition, recent studies have shown that inflammation, probably mediated by macrophages, mediates the pathogenesis associated to high levels of homocysteine (Hcy).
Rafael Fernandes, Zanin +5 more
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Extracellular Mitochondrial ATP, Suramin, and Autism?
Clinical Therapeutics, 2013& 2013 Elsevier HS Journals, Inc. All rights reserved. A recent publication reported that pregnant mice injected with the viral-like material Poly(I:C) produced, as previously known, offspring that exhibit behavior reminiscent of autism; it also reported that therapy with the antipurinergic drug suramin, used to treat the African disease ...
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Extracellular ATP Induces Calcium Signaling in Odontoblasts
Journal of Dental Research, 2016Odontoblasts form dentin at the outermost surface of tooth pulp. An increasing level of evidence in recent years, along with their locational advantage, implicates odontoblasts as a secondary role as sensory or immune cells. Extracellular adenosine triphosphate (ATP) is a well-characterized signaling molecule in the neuronal and immune systems, and ...
B M, Lee +7 more
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Mechanism of human sperm activation by extracellular ATP
American Journal of Physiology-Cell Physiology, 1996We have identified the mechanism whereby extracellular ATP (ATPe) triggers the acrosome reaction in human spermatozoa. This nucleotide opens a ligand-gated ion channel expressed on the sperm plasma membrane. ATPe threshold and 50% effective concentration calculated on the total added ATPe are 0.1 and 2 mM, respectively, corresponding to a free ATP ...
FORESTA, CARLO +3 more
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Extracellular ATP-Induced Apoptosis in PC12 Cells
1998Studies in our laboratory indicate that extracellular ATP (ATP)o may induce cell death by reactive oxygen insults. We have also shown that the Ca(2+)-induced oxidative stress as elicited by ATP may lead to an activation of a specific AP-1 activity. Since early impairment of mitochondria constitutes a critical event of the apoptotic cell death, we have ...
A Y, Sun, Y M, Chen
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Extracellular ATP and adenosine: The Yin and Yang in immune responses?
Molecular Aspects of Medicine, 2017Extracellular adenosine 5'-triphosphate (ATP) and adenosine molecules are intimately involved in immune responses. ATP is mostly a pro-inflammatory molecule and is released during hypoxic condition and by necrotic cells, as well as by activated immune cells and endothelial cells.
Faas, M., Sáez, Tamara, De Vos, P.
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In Vitro Cytotoxic Effects of Extracellular ATP
Alternatives to Laboratory Animals, 1992ATP is released in the body from several cells under various physiological and pathological conditions. A number of authors have postulated a role for extracellular ATP (ATPo) as a neurotransmitter, a secretagogue or an inflammatory mediator. Here, we propose an additional role for ATPo, as a cytotoxic factor, and discuss in vitro experiments showing ...
MURGIA, MARTA +4 more
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Arteriolar responses to extracellular ATP in striated muscle
American Journal of Physiology-Heart and Circulatory Physiology, 1997Blood flow and its distribution must be appropriately regulated to ensure that perfusion is matched to local tissue demands. We investigated the role of ATP in triggering a conducted alteration in arteriolar diameter in the Saran-covered cheek pouch retractor muscle of anesthetized hamsters (n = 60).
W T, McCullough +2 more
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