Results 101 to 110 of about 2,813,323 (292)

DCs facilitate B cell responses against microbial DNA via DC-SIGN.

PLoS ONE, 2017
Microbial DNA is highly immunostimulatory and is sensed by endosomal pattern recognition receptors after release from internalized microbes. It is unclear how extracellular DNA released from dead microbes is delivered to endosomal PRRs to induce immune ...
Joris K Sprokholt, Marieke H Heineke, Tanja M Kaptein, John L van Hamme, Teunis B H Geijtenbeek   +4 more
doaj   +1 more source

Extracellular Accumulation of DNA by Hydrocarbon-utilizing Bacteria

Agricultural and Biological Chemistry, 1972
Some hydrocarbon-utilizing bacteria grown on n-paraffin as the sole source of carbon accumulated extracellularly a considerable amount of DNA (0.1 g to 0.6 g per liter) which was free from intact cells and slime materials. This was particularly noted when the strains belonging to Pseudomonad were employed.
TOMITA, Fusao, SUZUKI, Takeo
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Extracellular Trap‐Mimicking DNA‐Histone Mesostructures Synergistically Activate Dendritic Cells [PDF]

, 2019
Extracellular traps (ETs), such as neutrophil extracellular traps, are a physical mesh deployed by immune cells to entrap and constrain pathogens. ETs are immunogenic structures composed of DNA, histones, and an array of variable protein and peptide ...
James J. Moon, Weerappuli, Priyan D., Moon, James J., Srilakshmi Yalavarthi, Luke Brennan, Cameron Louttit, Taisuke Kojima, Brennan, Luke, Louttit, Cameron, Kim, Hong Sun, Knight, Jason S., Xu, Yao, Takayama, Shuichi, Shuichi Takayama, Lukasz J. Ochyl, Kojima, Taisuke, Ochyl, Lukasz J., Yalavarthi, Srilakshmi, Midori L. Maeda, Maeda, Midori L., Hong Sun Kim, Priyan D. Weerappuli, Jason S. Knight, Yao Xu   +23 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Extracellular DNA ecology in EBV-associated nasopharyngeal carcinoma

Frontiers in Immunology
Epstein–Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) contains several overlapping DNA pools, including viral DNA, tumor-derived nuclear DNA, mitochondrial DNA (mtDNA), neutrophil extracellular trap (NET) chromatin, and DNA released during ...
Yingxin Xia, Zhenglin He, Xiaoye Wang, Haixiang Xue   +3 more
doaj   +1 more source

Extracellular DNA Shields against Aminoglycosides in Pseudomonas aeruginosa Biofilms

, 2013
Within recent years, it has been established that extracellular DNA is a key constituent of the matrix of microbial biofilms. In addition, it has recently been demonstrated that DNA binds positively charged antimicrobials such as aminoglycosides and ...
Høiby, Niels, Nielsen, Thomas Eiland, Nielsen, Thomas, Nilsson, Martin, Jensen, Peter Østrup, Chiang, Wen-Chi, Givskov, Michael, Tolker-Nielsen, Tim   +7 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Actin and DNA protect histones from degradation by bacterial proteases but inhibit their antimicrobial activity

Frontiers in Microbiology, 2016
Histones are small polycationic proteins located in the cell nucleus. Together, DNA and histones are integral constituents of the nucleosomes. Upon apoptosis, necrosis and infection - induced cell death, histones are released from the cell.
Asaf Sol, Yaniv Skivrsky, Edna Blotnick, Gilad Bachrach, Andras Muhlrad   +4 more
doaj   +1 more source

Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways

, 2011
Asthma is a heterogeneous inflammatory airway disorder that involves eosinophilic and noneosinophilic phenotypes. Unlike in healthy lungs, eosinophils are often present in atopic asthmatic airways, although a subpopulation of asthmatic subjects ...
Simon, Hans-Uwe, Hans-Uwe Simon, Dworski, Ryszard, Aimee Hoskins, Hoskins, Aimee, Shida Yousefi, Ryszard Dworski, Yousefi, Shida   +7 more
core   +1 more source