Results 81 to 90 of about 2,813,323 (292)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines [Elektronisk resurs]

, 2018
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures ...
Bryl-Gorecka, Paulina,, Théry, C,, International Society for Extracellular Vesicles, Lund University., Zuba-Surma, E. K.,   +4 more
core   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

An exposure to the oxidized DNA enhances both instability of genome and survival in cancer cells. [PDF]

PLoS ONE, 2013
BACKGROUND:Cell free DNA (cfDNA) circulates throughout the bloodstream of both healthy people and patients with various diseases and acts upon the cells. Response to cfDNA depends on concentrations and levels of the damage within cfDNA.
Svetlana V Kostyuk, Marina S Konkova, Elizaveta S Ershova, Anna J Alekseeva, Tatiana D Smirnova, Sergey V Stukalov, Ekaterina A Kozhina, Nadezda V Shilova, Tatiana V Zolotukhina, Zhanna G Markova, Vera L Izhevskaya, Ancha Baranova, Natalia N Veiko   +12 more
doaj   +1 more source

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

, 2009
Neutrophil extracellular traps (NETs) represent extracellular structures able to bind and kill microorganisms. It is believed that they are generated by neutrophils undergoing cell death, allowing these dying or dead cells to kill microbes. We show that,
E Kozlowski, Kozlowski, E, I Schmid, Simon, H U, Schmid, I, S Yousefi, H U Simon, Yousefi, S, Mihalache, C, C Mihalache, Yousefi S, Kozlowski E, Yousefi, Shida, Simon HU, Mihalache C, Schmid I, Simon, Hans-Uwe   +16 more
core   +1 more source

Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism [PDF]

, 2018
BackgroundVenous thromboembolism (VTE) is a major cause of morbidity and mortality in elderly patients. Extracellular DNA is a pro-inflammatory and pro-thrombotic mediator in vitro and in animal models. Levels of circulating extracellular DNA (ceDNA) are
Miguel Jiménez-Alcázar, Thomas Renné, Tobias A. Fuchs, Limacher, Andreas, Beer, Jürg H, Drahomir Aujesky (174917), Fuchs, Tobias A, Drahomir Aujesky, Aujesky, Drahomir, Jiménez-Alcázar, Miguel, Peine, Sven, Marie Méan, Josephine Bitterling (4884457), Lämmle, Bernhard, Sven Peine (3545648), Tobias A. Fuchs (4884466), Rachita Panda (4884463), Marie Méan (591355), Jürg H. Beer (4884469), Beer, Jürg, Miguel Jiménez-Alcázar (4884460), Andreas Limacher, Bernhard Lämmle, Renné, Thomas, Sven Peine, Rachita Panda, Jürg H. Beer, Josephine Bitterling, Panda, Rachita, Andreas Limacher (591356), Méan, Marie, Bernhard Lämmle (691655), Thomas Renné (93830), Bitterling, Josephine, Renné, T., Beer, J.H., Renné, T, Aujesky, D, Lämmle B, Fuchs, T.A., Limacher, A, Beer, JH, Panda, R, Aujesky, D., Aujesky D, Méan M, Méan, M., Méan, M, Bitterling J, Bitterling, J., Lämmle, B., Peine, S, Limacher, A., Bitterling, J, Panda R, Peine S, Peine, S., Fuchs TA, Limacher A, Renné T, Jiménez-Alcázar, M, Jiménez-Alcázar M, Beer JH, Jiménez-Alcázar, M., Panda, R., Lämmle, B   +65 more
core   +2 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Competence-independent activity of pneumococcal EndA [corrected] mediates degradation of extracellular dna and nets and is important for virulence. [PDF]

PLoS ONE, 2013
Membrane surface localized endonuclease EndA of the pulmonary pathogen Streptococcus pneumoniae (pneumococcus) is required for both genetic transformation and virulence. Pneumococcus expresses EndA during growth.
Luchang Zhu, Zhizhou Kuang, Brenda A Wilson, Gee W Lau   +3 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Unravelling the Significance of Extracellular Vesicle-Associated DNA in Cancer Biology and Its Potential Clinical Applications

Extracellular vesicles (EVs) play a key role in cell-to-cell communication and have drawn significant attention due to their potential clinical applications. However, much remains to be understood about the biology of EV-associated DNA (EV-DNA).
Licha, Kristina, Reinhardt, Dirk, Lötvall, Jan,, Pour, Ommolbanin Asad, Chetty, Venkatesh Kumar, Tamasova, Barbora, Ghanam, Jamal, Thakur, Basant Kumar, Hoyer, Peter   +8 more
core   +1 more source