Results 171 to 180 of about 1,499,817 (257)

Isolation of environmental lignin-degrading bacteria and identification of extracellular enzymes [PDF]

A novel screening method for detecting lignin-degradation activity on agar plates was developed using nitrated lignin. Using this method, ten lignindegrading bacteria have been isolated from environmental sources, including seven mesophilic soil ...
Taylor, C. R. (Charles R.)
core  

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy

Advanced Materials, EarlyView.
The lanthanide/transition metal ion coordination nanoparticles, La‐Cu@Lap/IWR‐1, with optimized coordination, have been proven to achieve remarkable results in realizing comprehensive tumor cuproptosis through efficient cuproptosis activation and multidimensional resistance elimination, thereby synchronously realizing the synergistic antitumor effects ...
Junrong Wang, Mengqian Xu, Huaping Zhao, Yulin Xie, Guoqing Zhu, Haoze Li, Qianqian Sun, Yong Lei, Chunxia Li   +8 more
wiley   +1 more source

Programmable Microgel Degradation in Dynamic Granular Hydrogels Guides Extracellular Matrix Assembly During Tissue Repair

Advanced Materials, EarlyView.
This study reports on the chemical modification of hyaluronic acid to create hydrogels with hydrolytic degradability ranging from 2–28 days. Granular hydrogels that undergo timed degradation to increase porosity enhance cell invasion and provisional ECM remodeling in a muscle injury model, leading to reduced fibrosis and improved regeneration ...
Zhiyuan Chen, Tuba Marjan, Xinyue Lu, Nicole E. Mertens, Keira Vesy, Dean E. Stornello, James F. Markworth, Taimoor H. Qazi   +7 more
wiley   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

Tailored Cationic Visible‐Light‐Active Interfaces for Sustainable, Biodegradable Nanofibers With Dual‐Mode Antimicrobial Activity and Robust Electrostatic Particle Capture

Advanced Materials, EarlyView.
Surface co‐functionalization of biodegradable nanofibers with sodium copper chlorophyllin and quaternary ammonium compounds achieves synergistic antimicrobial activity through combined photodynamic and contact‐killing mechanisms. The cationic surface provides humidity‐resistant electrostatic particle capture while maintaining rapid enzymatic ...
Dong Uk Lee, Jae Hak Shin, Seung Yeon Lee, In Ho Kim, Jiho Choi, Joon Young Park, Sang Bok Kim, Jeong Sang Son, Sang Hun Kim, Jae Hee Jung, Dong Yun Choi   +10 more
wiley   +1 more source

Defined Matrices Reveal Epithelial‐ and Mesenchymal‐Specific Responses to Stiffness and Adhesion in Human iPSC‐Derived Intestinal Organoids

Advanced Materials, EarlyView.
Defined PEG hydrogels enable human iPSC‐derived intestinal organoid culture without Matrigel. PEG‐ and Matrigel‐cultured organoids both support duodenal‐like epithelial identity, but direct comparison reveals subtle epithelial differentiation‐marker shifts and stronger mesenchymal ECM‐remodeling/integrin programs in PEG.
Alicja Kuziola, Tamara Fawzi, Emma H. Kromann, Marion Leleu, Joanna M. Drelinkiewicz, Dusko Ilic, Cécile A. Dreiss, Joana F. Neves, Eileen Gentleman   +8 more
wiley   +1 more source

A Coaxial Bioprinted Hydrogel With Semipermeable Sheath and Pro‐Chondrogenic Core for Articular Cartilage Repair

Advanced Materials, EarlyView.
A sheath‐core biomimetic hydrogel is engineered with a compartmentalized yet integrated architecture for synergistic multifunctionality. Its stiff, semipermeable sheath mimics the ECM's load‐bearing and protective roles, encapsulating a soft core that provides a pro‐chondrogenic microenvironment similar to the PCM.
Zheyuan Shi, Hua Zhang, Jingying Hu, Guanrong Li, Dianqing Wang, Cuicui Su, Gordon G. Wallace, Qi Gu, Jun Chen, Yingchun Zhu   +9 more
wiley   +1 more source

Life‐Like Ferrous Oxide Microspheres from Kombucha

Advanced Materials Interfaces, EarlyView.
Kombucha bacterial cellulose, sodium alginate, and ferrous nitrate self‐assemble into membrane‐enclosed iron oxide microspheres. These microspheres bud daughter vesicles, sustain 24‐h electrochemical oscillations, and filter theta‐band signals.
Panagiotis Mougkogiannis, Anna Nikolaidou, Andrew Adamatzky   +2 more
wiley   +1 more source

Bilayered PEDOT:PSS–Collagen Scaffolds as Functional Architectures for Tissue Engineering

Advanced Materials Interfaces, EarlyView.
A bilayered scaffold integrates collagen and PEDOT:PSS as distinct yet interconnected 3D matrices, preserving their fibrillar and conductive characteristics. Spatial compartmentalization enables independent tailoring of each domain while maintaining mechanical stability and compatibility with electrochemical monitoring, providing a multifunctional ...
Rasha Nasser, Jiranuwat Sapudom, Sotiris Psilodimitrakopoulos, Emmanuel Stratakis, Jeremy Teo, Vincent Chan, Charalampos Pitsalidis   +6 more
wiley   +1 more source