Results 191 to 200 of about 673,761 (305)

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source

A responsive living material prepared by diffusion reveals extracellular enzyme activity of cyanobacteria. [PDF]

Proc Natl Acad Sci U S A
Tang L, Soulier NT, Wheeler R, Pokorski JK, Golden JW, Golden SS, Bae J.   +6 more
europepmc   +1 more source

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

The application of straw returning combined with low-temperature degrading microbial inoculant M44 in cold and arid regions promotes the efficient decomposition of returned straw through the hierarchical interaction mechanism of "key microorganisms-bacterial community structure-extracellular enzyme activity-straw degradation". [PDF]

Front Microbiol
Zhao W, Wang L, Liu R, Jiang H, Li D, Hu S, Gao J, Yu X, Borjigin Q.   +8 more
europepmc   +1 more source

ADAMTS7 extracellular matrix enzyme expression is required for optimal influenza-specific CD8+T cell immunity

, 2018
ADAMTS7 extracellular matrix enzyme expression is required for optimal influenza-specific CD8+T cell ...
Meagan McMahon (7827716), Siying Ye (13094898), Ralph A Tripp (13500649), Daniel Dlugolenski (13066383), Daniel McCulloch (13562389), John Stambas (13077333)   +5 more
core  

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Biochar Amendment Increases Peanut Production Through Improvement of the Extracellular Enzyme Activities and Microbial Community Composition in Replanted Field. [PDF]

Plants (Basel)
Liu C, Shang S, Wang C, Tian J, Zhang L, Liu X, Bian R, He Q, Zhang F, Chen L, Drosos M, Azeem M, Li L, Shan S, Pan G.   +14 more
europepmc   +1 more source

Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids

Advanced Healthcare Materials, EarlyView.
Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López, Jose I. Garcia‐Peiro, Felipe Hornos, Jose L. Hueso, Jesus Santamaria, J. Manuel Garcia‐Aznar   +5 more
wiley   +1 more source

Response of Extracellular Enzyme Stoichiometric Properties and Microbial Metabolic Limitations to the Ecosystem Transition Mode Employed in Red Jujube Economic Forests on the Loess Plateau. [PDF]

Microorganisms
Mu C, Li J, Huang F, Zhang Z, Qin J, Wang G.   +5 more
europepmc   +1 more source

Patterns and Drivers of Extracellular Enzyme Activity in New Zealand Glacier-Fed Streams. [PDF]

Front Microbiol, 2020
Kohler TJ, Peter H, Fodelianakis S, Pramateftaki P, Styllas M, Tolosano M, de Staercke V, Schön M, Busi SB, Wilmes P, Washburne A, Battin TJ.   +11 more
europepmc   +1 more source