Bioprospecting and functional characterization of crude extracellular lipases from Antarctic
The MicrobeAntarctic ecosystems host diverse psychrophilic microorganisms, and soils influenced by seabird colonies, which are enriched in organic matter, represent promising sources of cold-adapted microorganisms with biotechnological potential.
Jeffrey Vargas-Pérez +7 more
doaj +1 more source
Applied Sciences, 2019 Microbial biomass, extracellular enzyme activity, and their stoichiometry in soil play an important role in ecosystem dynamics and functioning. To better understand the improvement of sand soil quality and the limitation of soil nutrients after adding ...
Xiuxiu Feng +4 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Extracellular proteolytic enzyme activity in sediments of an intertidal mudflat [PDF]
Limnology and Oceanography, 1989 Extracellular proteolytic activity (EPA) on an intertidal mudflat was examined over a 2‐yr period, with focus on characteristics of enzyme systems and the controlling influences on enzyme activity levels. EPA was primarily associated with the particulate rather than the pore‐water phase.
openaire +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Syndecan-4 regulates cell-surface trafficking and biological activity of transglutaminase-2 [PDF]
, 2009 Transglutaminase-2 (TG2) is a Ca2+-dependent crosslinking enzyme involved in the post-translational modification of proteins via the formation of Nε(γ-glutamyl)lysine isodipeptides.
Scarpellini, A
core
Production of bioactive peptides through sequencial action of Yarrowia lipolytica proteases and chemical glycation [PDF]
, 2013 This PhD thesis is aimed at studying the suitability of proteases realised by Yarrowia lipolytica to hydrolyse proteins of different origins available as industrial food by-products. Several strains of Y.
Gottardi, Davide <1983>
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Syndecan-4 knockout leads to reduced extracellular transglutaminase-2 and protects against tubulointerstitial fibrosis [PDF]
, 2014 Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. The interaction of TG2 with the heparan sulfate proteoglycan syndecan-4 (Sdc4) regulates the cell surface trafficking, localization, and ...
Schroeder, N +6 more
core +1 more source