Results 91 to 100 of about 8,496,804 (298)

Inhibition of Extracellular Enzyme Activity by Reactive Oxygen Species upon Oxygenation of Reduced Iron-Bearing Minerals

, 2023
The dual roles of minerals in inhibiting and prolonging extracellular enzyme activity in soils and sediments are governed by enzyme adsorption to mineral surfaces.
Dongyi Guo (8536410), Ravi Kukkadapu (1531816), Yizhi Sheng (763442), Qiang Zeng (107455), Jinglong Hu (9520017), Hailiang Dong (105368)   +5 more
core   +1 more source

Extracellular amylolytic activity in marine Croceibacter sp. 23-6: Cu2+ response and optimized wheat starch hydrolysis [PDF]

PeerJ
Background Marine bacteria are important sources of extracellular hydrolytic enzymes, but the amylolytic activity of many non-model marine bacterial lineages remains insufficiently characterized at the phenotype level.
Fangyan Jiang, Yuanyuan Zhang, Hongjin Zhang, Xiuqing Lin, Xiaoxiong Xu, Huimin Feng   +5 more
doaj   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Soil physicochemical properties, C pool characteristics, and extracellular enzyme activity as the succession progresses

Soil physicochemical properties, C pool characteristics, and extracellular enzyme activity as the succession ...
Pang, Yue
core   +1 more source

Extracellular enzyme activity in the Arctic Northeast Water polynya

Marine Ecology Progress Series, 1994
We studied extracellular enzyme activity (EEA) in samples of the water column and sediments of the Northeast Water polynya (77" to 81" N, 6" to 17' W) during July-August 1992 in order to determine controls on bacterial hydrolytic activity and possible roles of EEA in the fates of particulate organic matter (POM) on an arctic continental shelf.
A Vetter Y, JW Deming
openaire   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Enzyme activity below the dynamical transition at 220K [PDF]

, 1998
Enzyme activity requires the activation of anharmonic motions, such as jumps between potential energy wells. However, in general, the forms and time scales of the functionally important anharmonic dynamics coupled to motion along the reaction coordinate ...
Smith, Jeremy C., Ferrand, Michel, Finney, John L., Hery, Stephanie, Dunn, Rachel V., Daniel, Roy M., Ferrand M, Daniel RM, Hery S, Finney J L, Smith JC, Dunn R   +11 more
core   +1 more source

Production and characterization of extracellular protease from horse fecal–originated Bacillus amyloliquefaciens SLBD

Journal of the Indonesian Tropical Animal Agriculture
Proteases are valuable industrial enzymes, yet most commercial preparations in Indonesia remain imported, underscoring the need to identify local, efficient producers.
M. Arifin, C. Budiman, H. Asis, I. I. Arief, A. I. Fajri, A. Apriantini, M. S. Soenarno   +6 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source