Results 111 to 120 of about 588,061 (299)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Microbial extracellular enzyme activities in Humex Lake Skjervatjern

Environment International, 1992
Two microbial extracellular enzyme activities (MEEA) were studied in HUMEX Lake Skjervatjern: acid phosphatase (APHA) and leucine aminopeptidase (LeuAMPA). Both enzyme activities varied in the vertical and horizontal scale in both lake sites. APHA varied in the acidfied Basin A between 945–1706 nmol L−1 h−1 and LeuAMPA between 3.7–25 nmol L−1 h−1. Both
openaire   +2 more sources

Enzymes in Action: An Interactive Activity Designed to Highlight Positive Attributes of Extracellular Enzymes Synthesized by Microbes

Journal of Microbiology & Biology Education, 2014
Microbial activities are widely exploited in the manufacture of valuable products. However, the many beneficial uses of microorganisms are often overshadowed by negative associations with disease and decay. This article describes an interactive activity aimed at school-aged children and members of the public, which introduces the concept of microbial ...
Gillespie, Rachel M. C., Stanley-Wall, Nicola R.   +1 more
openaire   +4 more sources

Aggregate-size effects on soil physical and chemical properties and microbial communities during wetland-to-upland transition in cold-region ecosystems of northeastern China [PDF]

Revista Brasileira de Ciência do Solo
Soil aggregates are critical for maintaining soil structure, nutrient cycling, and microbial habitats, but their dynamics under land-use change remain unclear in cold-region ecosystems.
Junnan Ding
doaj   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Linking Microbial Functional Gene Abundance and Daqu Extracellular Enzyme Activity: Implications for Carbon Metabolism during Fermentation. [PDF]

Foods, 2022
Zhang YT, Deng YK, Zou YF, Han BL, Pu JZ, Rao JQ, Huang D, Luo HB.   +7 more
europepmc   +1 more source

Protease activity of extracellular enzyme produced by B. subtilis isolated from soil [PDF]

, 2017
Background: Proteases produced by enzymatic method are more environments friendly than chemical process, and they have tremendous potential in the leather industry and in other several industries.
uddin, M. E. (Md), Karim, M. R. (Mohammad), Ahamad, T. (Tasnim), Rahman, S. (Sezanur), Hossain, M. J. (Md), Alam, M. S. (Mohammad), Maitra, P. (Pulak), Nazmuzzaman, M. (Md), Islam, M. S. (Md), Mahmood, M. S. (Mohammad), alam, M. G. (Md)   +10 more
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source