Results 111 to 120 of about 8,496,804 (298)

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Enzyme dynamics and activity: timescale dependence of dynamical transitions in glutamate dehydrogenase solution [PDF]

, 1999
We have examined the temperature dependence of motions in a cryosolution of the enzyme glutamate dehydrogenase (GDH) and compared these with activity.
Daniel, Roy, Thomas, Ferrand, Michel, Daniel, Roy,, Finney, John, Reat, Valerie, Smith, Jeremy C., Smith, Jeremy, Finney, John L., Dunn, Rachel, Dunn, Rachel V., Daniel, Roy M., John L. Finney, Roy M. Daniel, Michel Ferrand, Valérie Réat, Jeremy C. Smith, Rachel Dunn, Ferrand M, Daniel RM, Finney J L, Dunn R, Reat V, Smith JC   +22 more
core   +1 more source

Effect of Coagulants, Somatic Cell Enzymes, and Extracellular Bacterial Enzymes on Plasminogen Activation

Journal of Dairy Science, 1991
Abstract Any factor that converts plasminogen (inactive form of the proteolytic enzyme plasmin) to plasmin in milk may have a negative impact on milk protein functionality. The effect of milk coagulants (calf rennet and proteases from Mucor miehei, Endothia parasitica, Mucor pusillus ), leukocytes from bovine blood, somatic cells from high SCC bovine
Robert J. Verdi, David M. Barbano
openaire   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Appendix A. Supplemental information used to quantify root biochemistry, extracellular enzyme activity, and functional gene abundance, as well as amplify fungal and bacterial DNA.

, 2016
Supplemental information used to quantify root biochemistry, extracellular enzyme activity, and functional gene abundance, as well as amplify fungal and bacterial ...
Donald R. Zak (349481), Lauren C. Cline (2929809)   +1 more
core   +1 more source

Microbial extracellular enzyme activities in Humex Lake Skjervatjern

Environment International, 1992
Two microbial extracellular enzyme activities (MEEA) were studied in HUMEX Lake Skjervatjern: acid phosphatase (APHA) and leucine aminopeptidase (LeuAMPA). Both enzyme activities varied in the vertical and horizontal scale in both lake sites. APHA varied in the acidfied Basin A between 945–1706 nmol L−1 h−1 and LeuAMPA between 3.7–25 nmol L−1 h−1. Both
openaire   +2 more sources

Enzymes in Action: An Interactive Activity Designed to Highlight Positive Attributes of Extracellular Enzymes Synthesized by Microbes

Journal of Microbiology & Biology Education, 2014
Microbial activities are widely exploited in the manufacture of valuable products. However, the many beneficial uses of microorganisms are often overshadowed by negative associations with disease and decay. This article describes an interactive activity aimed at school-aged children and members of the public, which introduces the concept of microbial ...
Gillespie, Rachel M. C., Stanley-Wall, Nicola R.   +1 more
openaire   +4 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Lipase activity in Thermus thermophilus HB8: Purification and characterization of the extracellular enzyme

Biotechnology and Bioprocess Engineering, 2012
In this study, the lipolytic activity of Thermus thermophilus HB8 was examined. The addition of various oils increased the production of extracellular lipolytic activity, while a combination of olive oil and glucose increased both extracellular and intracellular lipolytic activity.
Kretza, E., Papaneophytou, C. P., Papi, M. R., Karidi, K., Kyparissidis, Konstantinos, Kyriakidis, Dimitrios   +5 more
openaire   +2 more sources

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source