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The extracellular matrix and atherosclerosis

Current Opinion in Lipidology, 1995
The vascular extracellular matrix is a collection of vastly different macromolecules organized by entanglement and cross-linking into a biomechanically active polymer that imparts regional tensile strength, viscoelasticity, and compressibility to the atherosclerotic lesion.
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Extracellular Matrix and Ageing

2018
The extracellular matrix (ECM) provides the environment for many cells types within the body and, in addition to the well recognised role as a structural support, influences many important cell process within the body. As a result, age-related changes to the proteins of the ECM have far reaching consequences with the potential to disrupt many different
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Regulation of extracellular matrix degradation by cell—extracellular matrix interactions

Cell Differentiation and Development, 1990
An appropriate balance of extracellular matrix synthesis and degradation is required for normal morphogenesis and maintenance of tissue architecture. Extracellular matrix molecules and their receptors, as well as proteinases and their inhibitors, are all involved in matrix remodeling.
Zena Werb   +5 more
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The extracellular matrix is instructive

BioEssays, 1986
AbstractThe extracellular matrix does more than just blanket cells; it also provides informational cues which affect a variety of developmental and cellular maintenance activities. The constituents of the matrix provide the fabric for cell motility and cell shape as well as anchorage sites for bioactive factors which directly affect the cell's ...
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Macrophages and the Extracellular Matrix

Macrophages are critical to the immune response, serving multiple essential roles in maintaining tissue homeostasis and providing immune protection. These cells also interact with and influence the extracellular matrix (ECM) by sensing and responding to its components. Such interactions between macrophages and the ECM are mediated through the secretion
William, Meza-Morales   +3 more
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Composition of the extracellular matrix of the peritoneum

Journal of the Society for Gynecologic Investigation, 2001
To localize the extracellular matrix proteins collagen I, collagen IV, fibronectin, and laminin in the peritoneal membrane.Peritoneal biopsies (n = 13) from the anterior abdominal wall and the uterine serosa (n = 3) were incubated with antibodies to collagen IV, laminin, collagen I, and fibronectin.
C A, Witz   +5 more
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The plant extracellular matrix

Current Opinion in Cell Biology, 1989
There is a lot of extmcellular matrix (EM) about, and most of it surrounds plant cells. But, despite its importance in functions ranging .from morphogenesis to pathogen resistance, relatively little work has been directed towards it at a cell biological level.
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Extracellular Matrix in Disc Degeneration

Journal of Bone and Joint Surgery, 2006
The extracellular matrix of the intervertebral disc structures contains many molecules also found in cartilage. The extremely polyanionic proteoglycans play a central role, particularly in the nucleus, by creating an osmotic environment leading to retention of water and ensuing resistance to deformation-important for the resilience of the tissue ...
Haoyu, Feng   +3 more
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The extracellular matrix: Summation

Journal of Cardiac Failure, 2002
The development and progression oflef t ventricular (LV) dysfunction and, ultimately, the clinical manifestation ofcongestive heart f (CHF) is due to the summation ofa number ofsystemic, cellular, and molecular abnormalities. The specific constellation ofabnormalities that contribute to the progression ofCHF is disease dependent, but it likely includes
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Extracellular Matrix

2023
Clive R, Roberts   +2 more
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