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Regulation of extracellular matrix degradation by cell—extracellular matrix interactions
Cell Differentiation and Development, 1990An appropriate balance of extracellular matrix synthesis and degradation is required for normal morphogenesis and maintenance of tissue architecture. Extracellular matrix molecules and their receptors, as well as proteinases and their inhibitors, are all involved in matrix remodeling.
Zena Werb +5 more
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Macrophages and the Extracellular Matrix
Macrophages are critical to the immune response, serving multiple essential roles in maintaining tissue homeostasis and providing immune protection. These cells also interact with and influence the extracellular matrix (ECM) by sensing and responding to its components. Such interactions between macrophages and the ECM are mediated through the secretionWilliam, Meza-Morales +3 more
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The extracellular matrix and atherosclerosis
Current Opinion in Lipidology, 1995The vascular extracellular matrix is a collection of vastly different macromolecules organized by entanglement and cross-linking into a biomechanically active polymer that imparts regional tensile strength, viscoelasticity, and compressibility to the atherosclerotic lesion.
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Composition of the extracellular matrix of the peritoneum
Journal of the Society for Gynecologic Investigation, 2001To localize the extracellular matrix proteins collagen I, collagen IV, fibronectin, and laminin in the peritoneal membrane.Peritoneal biopsies (n = 13) from the anterior abdominal wall and the uterine serosa (n = 3) were incubated with antibodies to collagen IV, laminin, collagen I, and fibronectin.
C A, Witz +5 more
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The extracellular matrix is instructive
BioEssays, 1986AbstractThe extracellular matrix does more than just blanket cells; it also provides informational cues which affect a variety of developmental and cellular maintenance activities. The constituents of the matrix provide the fabric for cell motility and cell shape as well as anchorage sites for bioactive factors which directly affect the cell's ...
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[Phylogenesis of the extracellular matrix].
Comptes rendus des seances de la Societe de biologie et de ses filiales, 1993The extracellular matrix constitutes a highly organized intercellular medium. In multicellular animals, it plays important functions for cell cohesion and for the modulation of cell differentiation and behaviour as well. All the investigations conducted in non-vertebrate species have shown that the extracellular matrix is present at the onset of the ...
Garrone, R. +6 more
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Extracellular Matrix in Disc Degeneration
Journal of Bone and Joint Surgery, 2006The extracellular matrix of the intervertebral disc structures contains many molecules also found in cartilage. The extremely polyanionic proteoglycans play a central role, particularly in the nucleus, by creating an osmotic environment leading to retention of water and ensuing resistance to deformation-important for the resilience of the tissue ...
Haoyu, Feng +3 more
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The extracellular matrix: Summation
Journal of Cardiac Failure, 2002The development and progression oflef t ventricular (LV) dysfunction and, ultimately, the clinical manifestation ofcongestive heart f (CHF) is due to the summation ofa number ofsystemic, cellular, and molecular abnormalities. The specific constellation ofabnormalities that contribute to the progression ofCHF is disease dependent, but it likely includes
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Annual Review of Cell and Developmental Biology, 1988
Fibronectin remains unique among matrix components because it exists in both soluble and matrix forms. It seems likely that the necessity to prevent inappropriate matrix assembly from soluble fibronectin results in a strict requirement for catalysis by specific cells to deposit fibronectin fibrils.
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Fibronectin remains unique among matrix components because it exists in both soluble and matrix forms. It seems likely that the necessity to prevent inappropriate matrix assembly from soluble fibronectin results in a strict requirement for catalysis by specific cells to deposit fibronectin fibrils.
openaire +3 more sources