Microgravity Effects on the Matrisome [PDF]
Cells, 2021 Gravity is fundamental factor determining all processes of development and vital activity on Earth. During evolution, a complex mechanism of response to gravity alterations was formed in multicellular organisms.
Ludmila Buravkova +3 more
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Pan-Cancer analysis of the expression and regulation of matrisome genes across 32 tumor types [PDF]
Matrix Biology Plus, 2019 The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines and growth factors collectively referred to as the matrisome.
Valerio Izzi +6 more
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Analysis of matrisome expression patterns in murine and human dorsal root ganglia [PDF]
Frontiers in Molecular Neuroscience, 2023 The extracellular matrix (ECM) is a dynamic structure of molecules that can be divided into six different categories and are collectively called the matrisome.
Robin Vroman +13 more
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Alterations of Matrisome Gene Expression in Naturally Aged and Photoaged Human Skin In Vivo
BiomoleculesThe main component of human skin is a collagen-rich extracellular matrix (ECM), known as the matrisome. The matrisome is essential for maintaining the structural integrity and mechanical properties of the skin.
Yan Yan +4 more
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The Matrisome as an Immunomodulator: A Role Far Beyond Its Structural Support [PDF]
BiomoleculesThe extracellular matrix (ECM) is a dynamic and complex three-dimensional network that provides structural support and mechanical stability to tissues. The complete repertoire of ECM and associated proteins has recently been cataloged as matrisome, which
Taihao Quan
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Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development [PDF]
Advanced ScienceEarly follicular development (EFD) spans the growth from primordial to small antral stages and is crucial for maintaining ovarian function. However, the specific role of matrisome during this process remains largely undefined.
Tong Wu +12 more
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The Matrix Reloaded: The Hepatic Matrisome as a Therapeutic Opportunity to Fight Liver Fibrosis [PDF]
BiomoleculesLiver fibrosis is the excessive accumulation of extracellular matrix (ECM) that occurs in most types of chronic liver diseases (CLDs) as a response to sustained liver injury.
Cristina Benavides +6 more
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A prognostic matrix gene expression signature defines functional glioblastoma phenotypes and niches [PDF]
Communications BiologyInteractions among tumor, immune, and vascular niches play major roles in glioblastoma (GBM) malignancy and treatment responses. The composition and heterogeneity of extracellular core matrix proteins (CMPs) that mediate such interactions are not well ...
Monika Vishnoi +13 more
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Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis [PDF]
Nature CommunicationsHuman cortical development is a complex process involving the proliferation, differentiation, and migration of progenitor cells, all coordinated within a dynamic extracellular matrix (ECM).
Do Hyeon Gim +6 more
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Atlas of mildly and highly insoluble matrisome driving liver fibrosis
Frontiers in PharmacologyThe excessive deposition and cross-linking of core matrisome components typically result in abnormal remodeling of the extracellular matrix (ECM), leading to increased liver stiffness and worsening liver fibrosis.
Wen Zhang +20 more
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