Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis [PDF]
, 2016 Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell population. Here we characterized two previously described tumor-promoting CAF sub-types, smooth muscle actin (SMA)-positive myofibroblasts and senescent fibroblasts ...
Brennan, PA +26 more
core +5 more sources
Proteomic analysis of the bovine and human ciliary zonule [PDF]
, 2016 PURPOSE: The zonule of Zinn (ciliary zonule) is a system of fibers that centers the crystalline lens on the optical axis of the eye. Mutations in zonule components underlie syndromic conditions associated with a broad range of ocular pathologies ...
Bassnett, Steven +3 more
core +2 more sources
BMP2/BMPR1A is linked to tumour progression in dedifferentiated liposarcomas [PDF]
, 2016 Bone Morphogenic Protein 2 (BMP2) is a multipurpose cytokine, important in the development of bone and cartilage, and with a role in tumour initiation and progression.
Cassidy, A.P. +3 more
core +3 more sources
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver [PDF]
, 2014 Background: Colorectal cancer is the third most frequently diagnosed cancer and the third cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic mechanisms controlling colorectal carcinogenesis have been identified, novel
Carr, Steven A +5 more
core +2 more sources
Spatial and temporal changes in extracellular elastin and laminin distribution during lung alveolar development [PDF]
, 2018 Lung alveolarization requires precise coordination of cell growth with extracellular matrix (ECM) synthesis and deposition. The role of extracellular matrices in alveogenesis is not fully understood, because prior knowledge is largely extrapolated from ...
Chen, Hui +9 more
core +2 more sources
Overexpression of the vitronectin v10 subunit in patients with nonalcoholic steatohepatitis: Implications for noninvasive diagnosis of NASH [PDF]
, 2018 Nonalcoholic steatohepatitis (NASH) is the critical stage of nonalcoholic fatty liver disease (NAFLD). The persistence of necroinflammatory lesions and fibrogenesis in NASH is the leading cause of liver cirrhosis and, ultimately, hepatocellular ...
Angelico, Francesco +10 more
core +2 more sources
Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters [PDF]
, 2013 The extracellular matrix (ECM) is a major component of tumors and a significant contributor to cancer progression. In this study, we use proteomics to investigate the ECM of human mammary carcinoma xenografts and show that primary tumors of differing ...
Anastassiades +58 more
core +2 more sources
Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival [PDF]
, 2018 The extracellular microenvironment is an integral component of normal and diseased tissues that is poorly understood owing to its complexity. To investigate the contribution of the microenvironment to lung fibrosis and adenocarcinoma progression, two ...
Alexandra Naba +25 more
core +1 more source
Towards definition of an ECM parts list: An advance on GO categories [PDF]
, 2012 Those of us interested in the extracellular matrix (ECM) are faced with significant challenges of definition. ECM proteins are large, complex and assembled into crosslinked insoluble matrices.
Hoersch, Sebastian +3 more
core +1 more source
Insider Trading:Extracellular Matrix Proteins and their Non-Canonical Intracellular Roles [PDF]
, 2015 In metazoans, the extracellular matrix (ECM) provides a dynamic, heterogeneousmicroenvironment that has important supportive and instructive roles.
Adams, Josephine C, Hellewell, Andrew L
core +2 more sources