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The Matrisome as an Immunomodulator: A Role Far Beyond Its Structural Support [PDF]

Biomolecules
The extracellular matrix (ECM) is a dynamic and complex three-dimensional network that provides structural support and mechanical stability to tissues. The complete repertoire of ECM and associated proteins has recently been cataloged as matrisome, which
Taihao Quan
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Analysis of matrisome expression patterns in murine and human dorsal root ganglia

Frontiers in Molecular Neuroscience, 2023
The extracellular matrix (ECM) is a dynamic structure of molecules that can be divided into six different categories and are collectively called the matrisome.
Robin Vroman, Rahel S. Hunter, Matthew J. Wood, Olivia C. Davis, Zoë Malfait, Dale S. George, Dongjun Ren, Diana Tavares-Ferreira, Theodore J. Price, Richard J. Miller, Anne-Marie Malfait, Fransiska Malfait, Rachel E. Miller, Delfien Syx   +13 more
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Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development [PDF]

Advanced Science
Early follicular development (EFD) spans the growth from primordial to small antral stages and is crucial for maintaining ovarian function. However, the specific role of matrisome during this process remains largely undefined.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
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The Matrix Reloaded: The Hepatic Matrisome as a Therapeutic Opportunity to Fight Liver Fibrosis [PDF]

Biomolecules
Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) that occurs in most types of chronic liver diseases (CLDs) as a response to sustained liver injury.
Cristina Benavides, Pepa Kecheva, Fernando Solano, Olga Martínez-Arroyo, Juan V. Esplugues, Ana Blas-García, Nadezda Apostolova   +6 more
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A prognostic matrix gene expression signature defines functional glioblastoma phenotypes and niches [PDF]

Communications Biology
Interactions among tumor, immune, and vascular niches play major roles in glioblastoma (GBM) malignancy and treatment responses. The composition and heterogeneity of extracellular core matrix proteins (CMPs) that mediate such interactions are not well ...
Monika Vishnoi, Zeynep Dereli, Zheng Yin, Elisabeth K. Kong, Meric Kinali, Kisan Thapa, Ozgun Babur, Kyuson Yun, Nourhan Abdelfattah, Xubin Li, Behnaz Bozorgui, Mary C. Farach-Carson, Robert C. Rostomily, Anil Korkut   +13 more
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Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis [PDF]

Nature Communications
Human cortical development is a complex process involving the proliferation, differentiation, and migration of progenitor cells, all coordinated within a dynamic extracellular matrix (ECM).
Do Hyeon Gim, Muhammad Z. K. Assir, Olivia Soper, Paul A. Fowler, Michael D. Morgan, Daniel A. Berg, Eunchai Kang   +6 more
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Inflammation-related citrullination of matrisome proteins in human cancer

Frontiers in Oncology, 2022
IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Pekka Rappu, Ujjwal Suwal, Elina Siljamäki, Jyrki Heino   +3 more
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The Matrisome Genes From Hepatitis B–Related Hepatocellular Carcinoma Unveiled

Hepatology Communications, 2021
Chronic hepatitis B virus (HBV) infection changes the composition of the extracellular matrix (ECM) and enables the onset and progression of hepatocellular carcinoma (HCC).
Wei Chen, Romain Desert, Xiaodong Ge, Hui Han, Zhuolun Song, Sukanta Das, Dipti Athavale, Hong You, Natalia Nieto   +8 more
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Pipeline for precise insoluble matrisome coverage in tissue extracellular matrices

Frontiers in Bioengineering and Biotechnology, 2023
The extracellular matrix (ECM) is assembled by hundreds of proteins orchestrating tissue patterning and surrounding cell fates via the mechanical–biochemical feedback loop.
Wei Chen, Wei Chen, Wen Zhang, Wen Zhang, Ning Zhang, Ning Zhang, Shuyan Chen, Shuyan Chen, Tao Huang, Tao Huang, Hong You, Hong You   +11 more
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Extracellular matrix gene expression signatures as cell type and cell state identifiers

Matrix Biology Plus, 2021
Transcriptomic signatures based on cellular mRNA expression profiles can be used to categorize cell types and states. Yet whether different functional groups of genes perform better or worse in this process remains largely unexplored.
Fabio Sacher, Christian Feregrino, Patrick Tschopp, Collin Y. Ewald   +3 more
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