Results 21 to 30 of about 4,103 (166)

The Matrisome, Inflammation, and Liver Disease [PDF]

Seminars in Liver Disease, 2020
AbstractChronic fatty liver disease is common worldwide. This disease is a spectrum of disease states, ranging from simple steatosis (fat accumulation) to inflammation, and eventually to fibrosis and cirrhosis if untreated. The fibrotic stage of chronic liver disease is primarily characterized by robust accumulation of extracellular matrix (ECM ...
Christine E, Dolin, Gavin E, Arteel
openaire   +2 more sources

The kidney matrisome in health, aging, and disease

Kidney International, 2022
Dysregulated extracellular matrix is the hallmark of fibrosis, and it has a profound impact on kidney function in disease. Furthermore, perturbation of matrix homeostasis is a feature of aging and is associated with declining kidney function. Understanding these dynamic processes, in the hope of developing therapies to combat matrix dysregulation ...
Lausecker, Franziska, Lennon, Rachel, Randles, Michael J   +2 more
openaire   +3 more sources

The cartilage matrisome in adolescent idiopathic scoliosis [PDF]

Bone Research, 2020
AbstractThe human spinal column is a dynamic, segmented, bony, and cartilaginous structure that protects the neurologic system and simultaneously provides balance and flexibility. Children with developmental disorders that affect the patterning or shape of the spine can be at risk of neurologic and other physiologic dysfunctions.
Carol A. Wise, Diane Sepich, Aki Ushiki, Anas M. Khanshour, Yared H. Kidane, Nadja Makki, Christina A. Gurnett, Ryan S. Gray, Jonathan J. Rios, Nadav Ahituv, Lila Solnica-Krezel   +10 more
openaire   +4 more sources

Inflammation-related citrullination of matrisome proteins in human cancer [PDF]

, 2023
IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Siljamäki Elina, Suwal Ujjwal, Rappu Pekka, Heino Jyrki   +3 more
core   +1 more source

Divide-and-Conquer Matrisome Protein (DC-MaP) Strategy: An MS-Friendly Approach to Proteomic Matrisome Characterization [PDF]

International Journal of Molecular Sciences, 2020
Currently, the extracellular matrix (ECM) is considered a pivotal complex meshwork of macromolecules playing a plethora of biomolecular functions in health and disease beyond its commonly known mechanical role. Only by unraveling its composition can we leverage related tissue engineering and pharmacological efforts. Nevertheless, its unbiased proteomic
Emna Ouni, Sébastien Pyr dit Ruys, Marie-Madeleine Dolmans, Gaëtan Herinckx, Didier Vertommen, Christiani A. Amorim   +5 more
openaire   +2 more sources

Age-Related Changes in the Matrisome of the Mouse Skeletal Muscle [PDF]

International Journal of Molecular Sciences, 2021
Aging is characterized by a progressive decline of skeletal muscle (SM) mass and strength which may lead to sarcopenia in older persons. To date, a limited number of studies have been performed in the old SM looking at the whole, complex network of the extracellular matrix (i.e., matrisome) and its aging-associated changes.
Francesco Demetrio Lofaro, Barbara Cisterna, Maria Assunta Lacavalla, Federico Boschi, Manuela Malatesta, Daniela Quaglino, Carlo Zancanaro, Federica Boraldi   +7 more
openaire   +4 more sources

Regulation of the E/I-balance by the neural matrisome

Frontiers in Molecular Neuroscience, 2023
In the mammalian cortex a proper excitatory/inhibitory (E/I) balance is fundamental for cognitive functions. Especially γ-aminobutyric acid (GABA)-releasing interneurons regulate the activity of excitatory projection neurons which form the second main class of neurons in the cortex.
Müller-Bühl, Cornelius (Dr. rer. nat.), Wegrzyn, David (Dr. rer. nat.), Bauch, Juliane (Dr. rer. nat.), Faissner, Andreas (Prof. Dr.)   +3 more
openaire   +4 more sources

Pipeline for precise insoluble matrisome coverage in tissue extracellular matrices

Frontiers in Bioengineering and Biotechnology, 2023
The extracellular matrix (ECM) is assembled by hundreds of proteins orchestrating tissue patterning and surrounding cell fates via the mechanical–biochemical feedback loop.
Wei Chen, Wei Chen, Wen Zhang, Wen Zhang, Ning Zhang, Ning Zhang, Shuyan Chen, Shuyan Chen, Tao Huang, Tao Huang, Hong You, Hong You   +11 more
doaj   +1 more source

matrisome expression matrix

, 2023
 Our current study will provide a low-cost, simple, reliable and effective pipeline for tissue insoluble matrisome analysis in the quest to comprehend ECM discovery proteomic studies.  
Wei Chen (6378209)
core   +1 more source

Developing a Modular Analysis Pipeline to Identify Critical Matrisome Components in Gynecological Disease [PDF]

The matrisome is an ensemble of genes that are highly relevant for characterizing the behavior of the extracellular matrix (ECM) during the onset and progression of many diseases.
Cook, Carson J.
core   +6 more sources