Results 21 to 30 of about 3,090 (127)

Mutations in a set of ancient matrisomal glycoprotein genes across neoplasia predispose to disruption of morphogenetic transduction

Computational and Systems Oncology, 2022
Misexpression and remodeling of the extracellular matrix is a canonical hallmark of cancer, although the extent of cancer‐associated aberrations in the genes coding for extracellular matrix (ECM) proteins and the consequences thereof are not well ...
Jimpi Langthasa, Satyarthi Mishra, Monica U, Ronak Kalal, Ramray Bhat   +4 more
doaj   +1 more source

Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of Cancer

Frontiers in Oncology, 2021
A growing body of literature links events associated with the progression and severity of immunity and inflammatory disease with the composition of the tissue extracellular matrix as defined by the matrisome.
Priyanka Hirani, Valentine Gauthier, Carys E. Allen, Thomas N. Wight, Oliver M. T. Pearce   +4 more
doaj   +1 more source

Comprehensive Profiling of Early Neoplastic Gastric Microenvironment Modifications and Biodynamics in Impaired BMP-Signaling FoxL1⁺-Telocytes

Biomedicines, 2022
FoxL1+telocytes (TCFoxL1+) are novel gastrointestinal subepithelial cells that form a communication axis between the mesenchyme and epithelium. TCFoxL1+ are strategically positioned to be key contributors to the microenvironment through production and ...
Alain B. Alfonso, Véronique Pomerleau, Vilcy Reyes Nicolás, Jennifer Raisch, Carla-Marie Jurkovic, François-Michel Boisvert, Nathalie Perreault   +6 more
doaj   +1 more source

In-silico definition of the Drosophila melanogaster matrisome

Matrix Biology Plus, 2019
The extracellular matrix (ECM) is an assembly of hundreds of proteins that structurally supports the cells it surrounds and biochemically regulates their functions.
Martin N. Davis, Sally Horne-Badovinac, Alexandra Naba   +2 more
doaj   +1 more source

Longevity-Promoting Pathways and Transcription Factors Respond to and Control Extracellular Matrix Dynamics During Aging and Disease

Frontiers in Aging, 2022
Aging is one of the largest risk factors for cancer, type 2 diabetes, osteoarthritis, cardiovascular diseases, and other age-related pathologies. Here, we give a detailed description of the interplay of chronic age-related pathologies with the remodeling
Tinka Vidović, Collin Y. Ewald
doaj   +1 more source

Proteomic Identification of a Gastric Tumor ECM Signature Associated With Cancer Progression

Frontiers in Molecular Biosciences, 2022
The extracellular matrix (ECM) plays an undisputable role in tissue homeostasis and its deregulation leads to altered mechanical and biochemical cues that impact cancer development and progression.
Ana M. Moreira, Ana M. Moreira, Ana M. Moreira, Rui M. Ferreira, Rui M. Ferreira, Patrícia Carneiro, Patrícia Carneiro, Joana Figueiredo, Joana Figueiredo, Hugo Osório, Hugo Osório, Hugo Osório, José Barbosa, José Barbosa, John Preto, John Preto, Perpétua Pinto-do-Ó, Perpétua Pinto-do-Ó, Perpétua Pinto-do-Ó, Fátima Carneiro, Fátima Carneiro, Fátima Carneiro, Fátima Carneiro, Raquel Seruca, Raquel Seruca, Raquel Seruca   +25 more
doaj   +1 more source

A pan-cancer analysis of matrisome proteins reveals CTHRC1 and a related network as major ECM regulators across cancers.

PLoS ONE, 2022
The extracellular matrix in the tumour microenvironment can regulate cancer cell growth and progression. A pan-cancer analysis of TCGA data from 30 cancer types, identified the top 5% of matrisome genes with amplifications or deletions in their copy ...
Keerthi Harikrishnan, Srinivas Sheshagiri Prabhu, Nagaraj Balasubramanian   +2 more
doaj   +2 more sources

Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling

eLife, 2021
Collagen-rich tissues have poor reparative capacity that predisposes to common age-related disorders such as osteoporosis and osteoarthritis. We used in vivo pulsed SILAC labelling to quantify new protein incorporation into cartilage, bone, and skin of ...
Yoanna Ariosa-Morejon, Alberto Santos, Roman Fischer, Simon Davis, Philip Charles, Rajesh Thakker, Angus KT Wann, Tonia L Vincent   +7 more
doaj   +1 more source

Chamber‐Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function

Advanced Healthcare Materials, EarlyView.
Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang, Myungji Kim, Hwanyong Choi, Jinseon Park, Minji Kim, Donghwan Kim, Bo Ram Lee, Jinah Jang   +7 more
wiley   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source