Results 21 to 30 of about 5,280 (176)

Proteomics, Glycomics, and Glycoproteomics of Matrisome Molecules

Molecular & Cellular Proteomics, 2019
The most straightforward applications of proteomics database searching involve intracellular proteins. Although intracellular gene products number in the thousands, their well-defined post-translational modifications (PTMs) makes database searching practical.
Rekha Raghunathan, Manveen K. Sethi, Joshua A. Klein, Joseph Zaia   +3 more
openaire   +2 more sources

Matrisome Deregulation in Ovarian Cancer Metastasis

Proceedings of IMPRS, 2020
Background and Hypothesis: Over 75% of ovarian cancer (OC) patients present with metastasis upon initial diagnosis. Since most are treated for metastatic disease, it is crucial that developing therapies target metastasis. Our analysis of OC transcriptomic changes revealed key changes in the matrisome.
Jessica Tedrow, Ji Wang, Anirban Mitra
openaire   +2 more sources

Age-Related Changes in the Matrisome of the Mouse Skeletal Muscle [PDF]

International Journal of Molecular Sciences, 2021
Aging is characterized by a progressive decline of skeletal muscle (SM) mass and strength which may lead to sarcopenia in older persons. To date, a limited number of studies have been performed in the old SM looking at the whole, complex network of the extracellular matrix (i.e., matrisome) and its aging-associated changes.
Francesco Demetrio Lofaro, Barbara Cisterna, Maria Assunta Lacavalla, Federico Boschi, Manuela Malatesta, Daniela Quaglino, Carlo Zancanaro, Federica Boraldi   +7 more
openaire   +4 more sources

Shifting Responsibly: The Importance of Striatal Modularity to Reinforcement Learning in Uncertain Environments [PDF]

, 2010
We propose here that the modular organization of the striatum reflects a context-sensitive modular learning architecture in which clustered striosome–matrisome domains participate in modular reinforcement learning (RL).
Ken-ichi eAmemori, Ken-ichi eAmemori, Leif G. Gibb, Leif G. Gibb, Ann M. Graybiel, Ann M. Graybiel   +5 more
core   +1 more source

The evolution of metazoan extracellular matrix [PDF]

, 2011
The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins.
Adams, Aouacheria, Ball, Barros, Bentley, Bergmeier, Boute, Chapman, Chiquet-Ehrismann, Couchman, Dehal, Engel, Ewan, Exposito, Exposito, Fahey, Gazave, Heino, Hohenester, Huhtala, Hutter, Huxley-Jones, Hynes, Hynes, Hynes, Hynes, King, King, Knack, Martindale, Merline, Myllyharju, Naba, Ozbek, Patthy, Philippe, Philippe, Pick, Putnam, Putnam, Ricard-Blum, Richard O. Hynes, Robertson, Sadler, Schaefer, Schierwater, Sebé-Pedrós, Shalchian-Tabrizi, Srivastava, Srivastava, Tucker, Wada, Whittaker, Whittaker, Yurchenco, Zhang   +55 more
core   +1 more source

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-Derived Extracellular Matrix [PDF]

, 2017
The extracellular matrix (ECM) is recognized as a diverse, dynamic, and complex environment that is involved in multiple cell-physiological and pathological processes.
Adams, Josephine C, Hellewell, Andrew L, Rosini, Silvia   +2 more
core   +2 more sources

Fibroblast subtypes define a metastatic matrisome in breast cancer [PDF]

JCI Insight, 2020
Small primary breast cancers can show surprisingly high potential for metastasis. Clinical decision-making for tumor aggressiveness, including molecular profiling, relies primarily on analysis of the cancer cells. Here we show that this analysis is insufficient - that the stromal microenvironment of the primary tumor plays a key role in tumor cell ...
Heather M. Brechbuhl, Alexander S. Barrett, Etana Kopin, Jaime C. Hagen, Amy L. Han, Austin E. Gillen, Jessica Finlay-Schultz, Diana M. Cittelly, Philip Owens, Kathryn B. Horwitz, Carol A. Sartorius, Kirk Hansen, Peter Kabos   +12 more
openaire   +2 more sources

Extracellular matrix endocytosis in controlling matrix turnover and beyond: emerging roles in cancer [PDF]

, 2016
The extracellular matrix (ECM) is a network of secreted proteins that, beyond providing support for tissues and organs, is involved in the regulation of a variety of cell functions, including cell proliferation, polarity, migration and oncogenic ...
Alanko, Arora, Arora, Arora, Arora, Arora, Benesh, Bonnans, Bravo-Cordero, Bundesmann, Clark, Coopman, Cukierman, Dozynkiewicz, Elena Rainero, Fan, Fan, Greyner, Hoshino, Hu, Huijbers, Hynes, Ikenaga, Jürgensen, Lee, Lee, Leonoudakis, Lobert, Madsen, Madsen, Madsen, Madsen, Melander, Messaritou, Mousavi, Naba, Palmieri, Phang, Quintanilla-Dieck, Rainero, Segal, Shi, Shi, Sinha, Sottile, Sung, Sung, Theocharis, Wienke, Wienke, Wolanska, Ye, Yoneda   +52 more
core   +1 more source

Matrisome Profiling During Intervertebral Disc Development And Ageing

Scientific Reports, 2017
AbstractIntervertebral disc (IVD) degeneration is often the cause of low back pain. Degeneration occurs with age and is accompanied by extracellular matrix (ECM) depletion, culminating in nucleus pulpous (NP) extrusion and IVD destruction. The changes that occur in the disc with age have been under investigation.
Caldeira, Joana B., Santa, Cátia, Osório, Hugo, Molinos, Maria, Manadas, Bruno, Gonçalves, Raquel, Barbosa, Mário   +6 more
openaire   +3 more sources

Ovarian cancer cell line panel (OCCP): Clinical importance of in vitro morphological subtypes [PDF]

, 2014
Epithelial ovarian cancer is a highly heterogeneous disease and remains the most lethal gynaecological malignancy in the Western world. Therapeutic approaches need to account for inter-patient and intra-tumoural heterogeneity and detailed ...
Beaufort, C.M. (Corine M.), Berns, P.M.J.J. (Els), Besselink, N. (Nicolle), Brenton, J.D. (James D.), Heine, A.A.J. (Anouk), Helleman, J. (Jozien), Helmijr, J. (Jean), Hoogstraat, M. (Marlous), IJcken, W.F.J. (Wilfred) van, Koudijs, M.J. (Marco J.), Murtaza, M. (Muhammed), Piskorz, A.M. (Anna M.), Ruigrok-Ritstier, K. (Kirsten), Smid, M. (Marcel)   +13 more
core   +1 more source