Heparanase: A Multitasking Protein Involved in Extracellular Matrix (ECM) Remodeling and Intracellular Events [PDF]
Cells, 2018 Heparanase (HPSE) has been defined as a multitasking protein that exhibits a peculiar enzymatic activity towards HS chains but which simultaneously performs other non-enzymatic functions.
Valentina Masola +3 more
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The Role of the Extracellular Matrix (ECM) in Wound Healing: A Review [PDF]
Biomimetics, 2022 Robert B Diller
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Extracellular Matrix (ECM) Aging in the Retina: The Role of Matrix Metalloproteinases (MMPs) in Bruch’s Membrane Pathology and Age-Related Macular Degeneration (AMD) [PDF]
BiomoleculesAli A Hussain
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Development potential of extracellular matrix hydrogels as hemostatic materials
Frontiers in Bioengineering and Biotechnology, 2023 The entry of subcutaneous extracellular matrix proteins into the circulation is a key step in hemostasis initiation after vascular injury. However, in cases of severe trauma, extracellular matrix proteins are unable to cover the wound, making it ...
Dan Cai, Wei Weng
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Extracellular Vesicles as Regulators of the Extracellular Matrix
Bioengineering, 2023 Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication.
Neil J. Patel +2 more
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Matrix Biology Plus, 2023 The healthy skeletal muscle extracellular matrix (ECM) has several functions including providing structural integrity to myofibers, enabling lateral force transmission, and contributing to overall passive mechanical properties.
Ross P. Wohlgemuth +5 more
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Interplay between Extracellular Matrix and Neutrophils in Diseases
Journal of Immunology Research, 2021 The extracellular matrix (ECM) is a highly dynamic and complex network structure, which exists in almost all tissues and is the microenvironment that cells rely on for survival.
Yanyan Zhu +6 more
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SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix
Molecular & Cellular Oncology, 2021 Cells that lack attachment to the extracellular matrix (ECM) experience metabolic defects that can lead to caspase-independent cell death. Recently, we discovered that serum and glucocorticoid kinase-1 (SGK1) plays a critical role in the regulation of ...
Jordan A. Cockfield, Zachary T. Schafer
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Exosome-mediated transduction of mechanical force regulates prostate cancer migration via microRNA
Biochemistry and Biophysics Reports, 2022 Physical cues in the extracellular microenvironment regulate cancer cell metastasis. Functional microRNA (miRNA) carried by cancer derived exosomes play a critical role in extracellular communication between cells and the extracellular microenvironment ...
Zhixiao Liu +5 more
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The Extracellular Matrix: Its Composition, Function, Remodeling, and Role in Tumorigenesis
Biomimetics, 2023 The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular processes, the extracellular matrix has been shown to have diverse ...
Kevin Dzobo, Collet Dandara
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