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The Proteolysis of ECM in Intervertebral Disc Degeneration
International Journal of Molecular Sciences, 2022 Intervertebral disc (IVD) degeneration (IDD) is a pathological process that commonly occurs throughout the human life span and is a major cause of lower back pain. Better elucidation of the molecular mechanisms involved in disc degeneration could provide
Cao Yang, Cao Yang, Gaocai Li
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The ECM: To Scaffold, or Not to Scaffold, That Is the Question
International Journal of Molecular Sciences, 2021 The extracellular matrix (ECM) has pleiotropic effects, ranging from cell adhesion to cell survival. In tissue engineering, the use of ECM and ECM-like scaffolds has separated the field into two distinct areas—scaffold-based and scaffold-free.
Jonard Corpuz Valdoz, Pam van Ry
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The ECM path of senescence in aging: components and modifiers
FEBS Journal, 2020 The extracellular matrix (ECM) is a key noncellular component in all organs and tissues. It is composed of a large number of proteins including collagens, glycoproteins (GP), and ECM‐associated proteins, which show diversity of biochemical and ...
Valery Krizhanovsky
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Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance We describe here the most comprehensive analyses of extracellular matrix (ECM) of pancreatic ductal adenocarcinoma (PDAC) yet available, which detected previously unknown molecular changes during PDAC progression in both mouse models and ...
Richard Hynes +2 more
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Remodeling the ECM: Implications for Metastasis and Tumor Dormancy
Cancers, 2021 Simple Summary In this perspective article we discuss the importance of investigating the role of the ECM on tumor metastasis and tumor dormancy. First, we discuss the importance of the ECM in cancer progression.
José Javier Bravo-Cordero +1 more
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Deciphering the Relevance of Bone ECM Signaling
Cells, 2020 Bone mineral density, a bone matrix parameter frequently used to predict fracture risk, is not the only one to affect bone fragility. Other factors, including the extracellular matrix (ECM) composition and microarchitecture, are of paramount relevance in
Natividad Alcorta +2 more
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Advanced Drug Delivery Reviews, 2016 Regenerative strategies such as stem cell-based therapies and tissue engineering applications are being developed with the aim to replace, remodel, regenerate or support damaged tissues and organs.
Katja Schenke-Layland +2 more
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Targeted Drug Delivery via the Use of ECM-Mimetic Materials
Frontiers in Bioengineering and Biotechnology, 2020 The use of drug delivery vehicles to improve the efficacy of drugs and to target their action at effective concentrations over desired periods of time has been an active topic of research and clinical investigation for decades. Both synthetic and natural
Kristi Kiick +2 more
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Journal of Integrative Neuroscience, 2022 Background: Rett syndrome is a rare genetic neurological syndrome that affects mostly females. The syndrome leads to severe impairments impacting all areas of the affected persons' life, including speech, mobility, eating, and breathing impairments.
Alen Kapel +3 more
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Annales Kinesiologiae, 2023 Regular physical activity and exercise are beneficial for both physical and mental health. However, in the elderly, the level of physical activity they partake in is consistently inadequate.
Tatjana Tomažič +2 more
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