Results 1 to 10 of about 1,263,220 (260)
Scientific Reports, 2021 TLR4 location, and bacterial species-derived lipopolysaccharides, play a significant role in the downstream activation of transcription factors, accessory molecules, and products.
Matthew Stephens +2 more
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Inflammation in Chronic Wounds [PDF]
International Journal of Molecular Sciences, 2016 Non-healing chronic wounds present a major biological, psychological, social, and financial burden on both individual patients and the broader health system. Pathologically extensive inflammation plays a major role in the disruption of the normal healing cascade.
Ruilong Zhao +4 more
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TLRs and chronic inflammation [PDF]
The International Journal of Biochemistry & Cell Biology, 2010 After the discovery of Toll-like receptors (TLRs), innate immune mechanisms came back in the focus of scientific research. With more and more mechanisms of TLR biology known, it has become clear that these and also other innate immune receptors are not only of crucial importance in the immune response to invading pathogens, but also play a role in the ...
Ospelt, C, Gay, S
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Prostaglandins and chronic inflammation [PDF]
Trends in Pharmacological Sciences, 2012 Chronic inflammation is the basis of various chronic illnesses including cancer and vascular diseases. However, much has yet to be learned how inflammation becomes chronic. Prostaglandins (PGs) are well established as mediators of acute inflammation, and recent studies in experimental animals have provided evidence that they also function in transition
Aoki, Tomohiro, Narumiya, Shuh
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Molecules, 2022 Vascular inflammation is directly responsible for atherosclerosis. 5,2′-Dibromo-2,4′,5′-trihydroxydiphenylmethanone (TDD), a synthetic bromophenol derivative, exhibits anti-atherosclerosis and anti-inflammatory effects.
Hongxia Yuan +6 more
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GSK3β-dependent lysosome biogenesis: An effective pathway to mitigate renal fibrosis with LM49
Frontiers in Pharmacology, 2022 Renal fibrosis is an incurable disorder characterised by an imbalance of the extracellular matrix (ECM) favouring excess production over degradation.
Jinhong Ren +13 more
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Glucocorticoids and chronic inflammation [PDF]
Rheumatology, 2016 Glucocorticoids are steroid hormones that once bound to their receptor interact with the DNA binding domain. Almost 1000-2000 genes are sensitive to their effects, including immune/inflammatory response genes. However, their role in pathophysiology and therapy is still debated.
Rainer H, Straub, Maurizio, Cutolo
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Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling
Molecular Brain, 2020 Postoperative shivering and cold hypersensitivity are major side effects of acute and chronic opioid treatments respectively. TRPM8 is a cold and menthol-sensitive channel found in a subset of dorsal root ganglion (DRG) nociceptors.
Mircea Iftinca +9 more
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Allergy, Asthma & Clinical Immunology, 2018 Background Asthma exacerbations are associated with the recruitment of neutrophils to the lungs. These cells release proteases and mediators, many of which act at G protein-coupled receptors (GPCRs) that couple via Gq to promote bronchoconstriction and ...
Tresa George +3 more
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Frontiers in Immunology, 2020 The rise of antimicrobial resistance (AMR) in bacterial pathogens is acknowledged by the WHO as a major global health crisis. It is estimated that in 2050 annually up to 10 million people will die from infections with drug resistant pathogens if no ...
Matthias Merker +19 more
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