Results 1 to 10 of about 1,887,624 (306)

Ultra-purification of Lipopolysaccharides reveals species-specific signalling bias of TLR4: importance in macrophage function

Scientific Reports, 2021
TLR4 location, and bacterial species-derived lipopolysaccharides, play a significant role in the downstream activation of transcription factors, accessory molecules, and products.
Matthew Stephens, Shan Liao, Pierre-Yves von der Weid   +2 more
doaj   +1 more source

5,2′-Dibromo-2,4′,5′-trihydroxydiphenylmethanone Inhibits LPS-Induced Vascular Inflammation by Targeting the Cav1 Protein

Molecules, 2022
Vascular inflammation is directly responsible for atherosclerosis. 5,2′-Dibromo-2,4′,5′-trihydroxydiphenylmethanone (TDD), a synthetic bromophenol derivative, exhibits anti-atherosclerosis and anti-inflammatory effects.
Hongxia Yuan, Qianyi Hou, Xiue Feng, Yuanlin Zhang, Fan Yang, Rui Ge, Qingshan Li   +6 more
doaj   +1 more source

The role of inflammation in age-related disease. [PDF]

, 2013
The National Institutes of Health (NIH) Geroscience Interest Group (GSIG) sponsored workshop, The Role of Inflammation inAge-Related Disease, was held September 6th-7th, 2012 in Bethesda, MD.
Augustine, Alison Deckhut, Campisi, Judith, Howcroft, T Kevin, Kohanski, Ron, Louis, Germaine Buck, McElhaney, Janet E, Sierra, Felipe, Smith, Martyn T, Wise, Bradley, Wyss-Coray, Tony   +9 more
core   +2 more sources

GSK3β-dependent lysosome biogenesis: An effective pathway to mitigate renal fibrosis with LM49

Frontiers in Pharmacology, 2022
Renal fibrosis is an incurable disorder characterised by an imbalance of the extracellular matrix (ECM) favouring excess production over degradation.
Jinhong Ren, Jinhong Ren, Huizhi Wei, Jian Sun, Xiue Feng, Yuanlin Zhang, Hongxia Yuan, Junqiu Miao, Xiaoming Qi, Xiaoming Qi, Yuanbiao Qiao, Baoguo Xiao, Qingshan Li, Qingshan Li   +13 more
doaj   +1 more source

Wuzi Yanzong Pill relieves CPZ-induced demyelination by improving the microenvironment in the brain

Heliyon, 2022
Ethnopharmacology relevance: Wuzi Yanzong Pill (WYP), a well-known prescription for invigorating the kidney and essence, which is widely used to treat infertility such as oligoasthenospermia.
Yan-Rong Li, Meng-Ying Sun, Wei Hang, Qi Xiao, Hui-Jie Fan, Lu Jia, Xiao-Ming Jin, Bo Zhang, Bao-Guo Xiao, Cun-Gen Ma, Zhi Chai   +10 more
doaj   +1 more source

Elimination of pain improves specificity of clinical diagnostic criteria for adult chronic rhinosinusitis [PDF]

, 2017
Objective Determine whether the elimination of pain improves accuracy of clinical diagnostic criteria for adult chronic rhinosinusitis. Study Design Retrospective cohort study.
DiNardo, Laurence J., Hirsch, Scott D., Reiter, Evan R., Schuman, Theodore A., Wan, Wen   +4 more
core   +2 more sources

Chronic gastrointestinal inflammation [PDF]

FEMS Immunology & Medical Microbiology, 1999
Chronic gastrointestinal inflammation is one of the most common types of inflammatory process which affects humans. It is diverse in aetiology, pathogenesis and manifestation. There are also features of chronic inflammation at different sites within the gastrointestinal tract which provide a common thread in terms of the approaches which may be used in
openaire   +2 more sources

Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling

Molecular Brain, 2020
Postoperative shivering and cold hypersensitivity are major side effects of acute and chronic opioid treatments respectively. TRPM8 is a cold and menthol-sensitive channel found in a subset of dorsal root ganglion (DRG) nociceptors.
Mircea Iftinca, Lilian Basso, Robyn Flynn, Charlie Kwok, Corinne Roland, Ahmed Hassan, Manon Defaye, Rithwik Ramachandran, Tuan Trang, Christophe Altier   +9 more
doaj   +1 more source

Integrated analysis of intratumoral biomarker and tumor-associated macrophage to improve the prognosis prediction in cancer patients

BMC Cancer, 2023
Background The lack of effective and accurate predictive indicators remains a major bottleneck for the improvement of the prognosis of patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Hepatitis B virus X (HBx) has been widely
Ming-Da Wang, Hao Xiang, Tian-Yu Hong, Abudurexiti Mierxiati, Fei-Hu Yan, Ling Zhang, Chao Wang   +6 more
doaj   +1 more source

A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation

Allergy, Asthma & Clinical Immunology, 2018
Background Asthma exacerbations are associated with the recruitment of neutrophils to the lungs. These cells release proteases and mediators, many of which act at G protein-coupled receptors (GPCRs) that couple via Gq to promote bronchoconstriction and ...
Tresa George, Mainak Chakraborty, Mark A. Giembycz, Robert Newton   +3 more
doaj   +1 more source