Results 11 to 20 of about 1,887,624 (306)

Evolutionary Approaches to Combat Antibiotic Resistance: Opportunities and Challenges for Precision Medicine

Frontiers in Immunology, 2020
The rise of antimicrobial resistance (AMR) in bacterial pathogens is acknowledged by the WHO as a major global health crisis. It is estimated that in 2050 annually up to 10 million people will die from infections with drug resistant pathogens if no ...
Matthias Merker, Matthias Merker, Matthias Merker, Leif Tueffers, Leif Tueffers, Marie Vallier, Marie Vallier, Espen E. Groth, Espen E. Groth, Espen E. Groth, Lindsay Sonnenkalb, Daniel Unterweger, Daniel Unterweger, John F. Baines, John F. Baines, Stefan Niemann, Stefan Niemann, Stefan Niemann, Hinrich Schulenburg, Hinrich Schulenburg   +19 more
doaj   +1 more source

One special question to start with: can HIF/NFkB be a target in inflammation? [PDF]

, 2015
Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to ...
CARNEVALE, ILARIA, DE SANTIS, Elena, Limana, F, Perrone, Ga, POLLETTA, LUCIA, RUNCI, ALESSANDRA, RUSSO, Matteo Antonio, SANSONE, LUIGI, TAFANI, MARCO   +8 more
core   +1 more source

Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells

BMC Medical Genomics, 2019
Background Glucocorticoids act on the glucocorticoid receptor (GR; NR3C1) to resolve inflammation and, as inhaled corticosteroids (ICS), are the cornerstone of treatment for asthma. However, reduced efficacy in severe disease or exacerbations indicates a
Mahmoud M. Mostafa, Christopher F. Rider, Suharsh Shah, Suzanne L. Traves, Paul M. K. Gordon, Anna Miller-Larsson, Richard Leigh, Robert Newton   +7 more
doaj   +1 more source

Erythrocyte phospho-signalling is dynamically altered during infection with Plasmodium falciparum

Microbial Cell, 2020
It is well established that intracellular pathogens mobilise signalling pathways to manipulate gene expression of their host cell to promote their own survival.
Jack D. Adderley, Christian Doerig
doaj   +1 more source

Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage [PDF]

, 2015
Background Traumatic brain injury can trigger chronic neuroinflammation, which may predispose to neurodegeneration. Animal models and human pathological studies demonstrate persistent inflammation in the thalamus associated with axonal injury, but this ...
Brooks, DJ, Hellyer, PJ, Matthews, PM, Ramlackhansingh, AF, Scott, G, Sharp, DJ   +5 more
core   +1 more source

Mesenteric Lymphatic Alterations Observed During DSS Induced Intestinal Inflammation Are Driven in a TLR4-PAMP/DAMP Discriminative Manner

Frontiers in Immunology, 2019
Background: Inflammatory bowel disease (IBD) is characterized by both acute and chronic phase inflammation of the gastro-intestinal (GI) tract that affect a large and growing number of people worldwide with little to no effective treatments.
Matthew Stephens, Shan Liao, Pierre-Yves von der Weid   +2 more
doaj   +1 more source

Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites [PDF]

, 2017
Inflammation can be protective or pathogenic depending on context and timeframe. Acute inflammation, including the accumulation of CD4 T cells, accompanies protective immune responses to pathogens, but the presence of activated CD4 T cells at sites of ...
Ammit, Barnden, Brinkmann, Brown, Chimen, Cyster, Debes, Faust, Firestein, Fu, Garrod, Gibson, Han, Hochreiter-Hufford, Hugues, Jo, Karuppuchamy, Kitano, Ledgerwood, Liao, Limaye, Lindquist, Mackay, Mackay, Mammoto, Masopust, Matloubian, Matsuura, McInnes, Means, Mempel, Mendoza, Murphy, Nowarski, Olivera, Priceman, Pyne, Sawicka, Skon, Smith, Spangrude, Tarrason, Teijeira, Tsunemi, Veres, Wang, Wang   +46 more
core   +3 more sources

Direct impact of commonly used dietary emulsifiers on human gut microbiota

Microbiome, 2021
Background Epidemiologic evidence and animal studies implicate dietary emulsifiers in contributing to the increased prevalence of diseases associated with intestinal inflammation, including inflammatory bowel diseases and metabolic syndrome.
Sabrine Naimi, Emilie Viennois, Andrew T. Gewirtz, Benoit Chassaing   +3 more
doaj   +1 more source

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma [PDF]

, 2016
Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial ...
Al-Riyami, L., Coltherd, J. C., Harnett, M. M., Harnett, W., Lawrie, R. E., Rodgers, D. T., Suckling, C. J.   +6 more
core   +1 more source

Cooperation between host immunity and the gut bacteria is essential for helminth-evoked suppression of colitis

Microbiome, 2021
Background Studies on the inhibition of inflammation by infection with helminth parasites have, until recently, overlooked a key determinant of health: the gut microbiota.
Adam Shute, Blanca E. Callejas, ShuHua Li, Arthur Wang, Timothy S. Jayme, Christina Ohland, Ian A. Lewis, Brian T. Layden, André G. Buret, Derek M. McKay   +9 more
doaj   +1 more source