Results 21 to 30 of about 1,263,220 (260)

Gut-innervating TRPV1+ Neurons Drive Chronic Visceral Pain via Microglial P2Y12 ReceptorSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Chronic abdominal pain is a common symptom of inflammatory bowel diseases (IBDs). Peripheral and central mechanisms contribute to the transition from acute to chronic pain during active disease and clinical remission.
Manon Defaye, Nasser S. Abdullah, Mircea Iftinca, Ahmed Hassan, Francina Agosti, Zizhen Zhang, Melissa Cumenal, Gerald W. Zamponi, Christophe Altier   +8 more
doaj   +1 more source

Social overcrowding impacts gut microbiota, promoting stress, inflammation, and dysglycemia

Gut Microbes, 2021
An array of chronic inflammatory diseases, including metabolic diseases such as obesity and diabetes, are thought to be promoted by disturbance of the intestinal microbiota.
Clara Delaroque, Mélissa Chervy, Andrew T. Gewirtz, Benoit Chassaing   +3 more
doaj   +1 more source

Chronic gastrointestinal inflammation [PDF]

FEMS Immunology & Medical Microbiology, 1999
Chronic gastrointestinal inflammation is one of the most common types of inflammatory process which affects humans. It is diverse in aetiology, pathogenesis and manifestation. There are also features of chronic inflammation at different sites within the gastrointestinal tract which provide a common thread in terms of the approaches which may be used in
openaire   +2 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Levels of immunoglobulin isotypes in serum and respiratory samples of patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis

Respiratory Research
COPD is a disease of progressive and irreversible airflow obstruction, with exacerbations (AECOPD) often triggered by infection. Immunoglobulins play an important role in immune defense and immune regulation, however their role in COPD is poorly ...
Dana Unninayar, Oluwafemi Segun-Ige, Luana Leticia Teixeira Nunes Porto, Beverley Shea, Donald William Cameron, Juthaporn Cowan   +5 more
doaj   +1 more source

Evaluation of Interleukin17and Interleukin 23 expression in patients with active and latent tuberculosis infection [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): Tuberculosis is one of the most important infectious diseases with high mortality rates worldwide, especially in developing countries. Interleukin17 (IL-17) is an important acquired immunity cytokine, which is mainly produced by CD4+TH17 ...
Fatemeh Heidarnezhad, Amir Asnaashari, Seyed Abdolrahim Rezaee, Roghayeh Ghezelsofla, Kiarash Ghazvini, Narges Valizadeh, Reza Basiri, Aghigh Ziaeemehr, Somayeh Sobhani, Houshang Rafatpanah   +9 more
doaj   +1 more source

Precision Nutrition in Chronic Inflammation [PDF]

Frontiers in Immunology, 2020
The molecular foundation of chronic inflammatory diseases (CIDs) can differ markedly between individuals. As our understanding of the biochemical mechanisms underlying individual disease manifestations and progressions expands, new strategies to adjust treatments to the patient’s characteristics will continue to profoundly transform clinical practice ...
Tobias J. Demetrowitsch, Kristina Schlicht, Carina Knappe, Johannes Zimmermann, Julia Jensen-Kroll, Alina Pisarevskaja, Alina Pisarevskaja, Fynn Brix, Juliane Brandes, Corinna Geisler, Georgios Marinos, Felix Sommer, Dominik M. Schulte, Christoph Kaleta, Vibeke Andersen, Vibeke Andersen, Vibeke Andersen, Matthias Laudes, Karin Schwarz, Silvio Waschina   +19 more
openaire   +4 more sources

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Awareness of organ donation among people living with HIV in Canada: a cross-sectional study

HIV Research & Clinical Practice
Background Advancements in antiretroviral therapy (ART) have significantly increased the life expectancy of people living with HIV, shifting the clinical focus from AIDS-related complications to the management of chronic conditions common in aging ...
Julia Nicholds, Michael Dans, Jonathan B. Angel   +2 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source