Results 31 to 40 of about 378,182 (255)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A Novel 3D Scaffold for Cell Growth to Assess Electroporation Efficacy

Cells, 2019
Tumor electroporation (EP) refers to the permeabilization of the cell membrane by means of short electric pulses thus allowing the potentiation of chemotherapeutic drugs.
Monica Dettin, Elisabetta Sieni, Annj Zamuner, Ramona Marino, Paolo Sgarbossa, Maria Lucibello, Anna Lisa Tosi, Flavio Keller, Luca Giovanni Campana, Emanuela Signori   +9 more
doaj   +1 more source

Osteogenic differentiation of human dental pulp stem cells in decellularised adipose tissue solid foams [PDF]

, 2022
3D cell culture systems based on biological scaffold materials obtainable from both animal and human tissues constitute very interesting tools for cell therapy and personalised medicine applications.
Briz, Nerea, Ibarretxe Bilbao, Gaskon, Madarieta, Iratxe, Pineda Martí, José Ramón, Luzuriaga González, Jon, Olalde, Beatriz, García Gallastegui, Patricia, Unda Rodríguez, Fernando José, García Urkia, Nerea, Irastorza Epelde, Igor, Fernandez San Argimiro, Francisco Javier   +10 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Pharmacokinetics and Toxicity of Dimethylacetamide and Its Metabolite in Pediatric Patients Treated With High Dose Intravenous Busulphan

Clinical and Translational Science
N,N‐dimethylacetamide (DMA) is an organic solvent, used in busulphan, iv‐formulation, (Busulfex). DMA is metabolized primarily to N‐methylacetamide (MMA) via CYP2E1.
Fadwa Benkessou, Ibrahim El‐Serafi, Rui He, Yikai Yin, Limei Ma, Xiaoli Li, Ahmed T. El‐Serafi, Ylva Terelius, Tayfun Gungör, Manuchehr Abedi‐Valugerdi, Tingting Wang, Weiyi Zheng, Chao Yu, Weiying Zhou, Massoud Vosough, Ying Zhao, Moustapha Hassan   +16 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Effects of Cell Seeding Methods on Chondrogenic Differentiation of Rat Mesenchymal Stem Cells in Polyhydroxybutyrate/Chitosan Scaffolds

Folia Veterinaria, 2019
The aim of our study was to examine the effects of passive and active cell seeding techniques on in vitro chondrogenic differentiation of mesenchymal stem cells (MSC) isolated from rat bone marrow and seeded on porous biopolymer scaffolds based on ...
Giretová M., Medvecký Ľ., Petrovová E., Čížková D., Mudroňová D., Danko J.   +5 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Implementing Dual Base Stations within an IoT Network for Sustaining the Fault Tolerance of an IoT Network through an Efficient Path Finding Algorithm

Sensors, 2023
The IoT networks for implementing mission-critical applications need a layer to effect remote communication between the cluster heads and the microcontrollers. Remote communication is affected through base stations using cellular technologies.
J. K. R. Sastry, Bhupati Ch, Raja Rao Budaraju   +2 more
doaj   +1 more source