Results 31 to 40 of about 200,715 (255)

Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis

Frontiers in Cell and Developmental Biology, 2021
Skin aging is a physiological issue that is still relatively poorly understood. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging.
Mansheng Li, Xiao Li, Binghui Liu, Luye Lv, Wenjuan Wang, Dunqin Gao, Qiyu Zhang, Junyi Jiang, Mi Chai, Zhimin Yun, Yingxia Tan, Feng Gong, Zhihong Wu, Yunping Zhu, Yunping Zhu, Jie Ma, Ling Leng   +16 more
doaj   +1 more source

Bursting Dynamics of Spiking Neural Network Induced by Active Extracellular Medium

Mathematics, 2023
We propose a mathematical model of a spiking neural network (SNN) that interacts with an active extracellular field formed by the brain extracellular matrix (ECM). The SNN exhibits irregular spiking dynamics induced by a constant noise drive.
Sergey V. Stasenko, Victor B. Kazantsev
doaj   +1 more source

The Extracellular Matrix, the Silent ‘Architect’ of Glioma

Biomedicines
The brain’s extracellular matrix (ECM) serves as a dynamic and instructive regulator of glioma progression. The ECM provides structural support while integrating pharmacological and mechanical signals that influence glioma initiation, progression, and ...
Carmen Rubio, Javier Pérez-Villavicencio, Nadia F. Esteban-Román, Ángel Lee, Gervith Reyes-Soto, Moisés Rubio-Osornio   +5 more
doaj   +1 more source

Extracellular matrix supports healing of transected rabbit Achilles tendon

Heliyon, 2018
Extracellular matrix (ECM) has been intensively used in cardio surgery. The main goal of this research was to determine if Achilles tendon healing could be promoted by applying extracellular matrix scaffold (CorMatrix®, USA). Sixteen (n = 16) New Zealand
Marija Lipar, Boris Zdilar, Mario Kreszinger, Marijana Ćorić, Berislav Radišić, Marko Samardžija, Rado Žic, Marko Pećin   +7 more
doaj   +1 more source

Fenofibrate attenuated glucose-induced mesangial cells proliferation and extracellular matrix synthesis via PI3K/AKT and ERK1/2. [PDF]

PLoS ONE, 2013
Excess mesangial extracellular matrix (ECM) and mesangial cell proliferation is the major pathologic feature of diabetic nephropathy (DN). Fenofibrate, a PPARα agonist, has been shown to attenuate extracellular matrix formation in diabetic nephropathy ...
Rui Zeng, Yan Xiong, Fengming Zhu, Zufu Ma, Wenhui Liao, Yong He, JinSeng He, Wei Li, Juan Yang, Qian Lu, Gang Xu, Ying Yao   +11 more
doaj   +1 more source

Matritecture: Mapping the extracellular matrix architecture during health and disease

Matrix Biology Plus, 2022
All cells in multicellular organisms are housed in the extracellular matrix (ECM), an acellular edifice built up by more than a thousand proteins and glycans.
Raphael Reuten, Alejandro E. Mayorca-Guiliani, Janine Terra Erler   +2 more
doaj   +1 more source

Macrophage-Mediated Bone Formation in Scaffolds Modified With MSC-Derived Extracellular Matrix Is Dependent on the Migration Inhibitory Factor Signaling Pathway

Frontiers in Cell and Developmental Biology, 2021
The positive role of macrophages in the osteogenesis of mesenchymal stem cells (MSCs) has been a recent research focus. On the other hand, MSCs could carefully regulate the paracrine molecules derived from macrophages.
Moyuan Deng, Jiulin Tan, Qijie Dai, Fei Luo, Jianzhong Xu   +4 more
doaj   +1 more source

Matrix metalloproteinase-induced cervical extracellular matrix remodelling in pregnancy and cervical cancer

Vascular Biology, 2022
The phenomenal extracellular matrix (ECM) remodelling of the cervix that precedes the myometrial contraction of labour at term or preterm appears to share some common mechanisms with the occurrence, growth, invasion and metastasis of cervical carcinoma ...
Emmanuel Amabebe, Henry Ogidi, Dilly O Anumba   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source