Results 41 to 50 of about 3,090 (127)
International Journal of Cancer, Volume 159, Issue 2, Page 501-515, 15 July 2026.What's new? Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor survival and variable response to perioperative chemotherapy. Although histopathological features correlate with outcomes, the relationship specifically between adherens junction (AJ) protein expression and treatment response in EAC remains uncertain.
Bastian Grothey +8 more
wiley +1 more source
The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.Abstract Desmoplasia, characterized by excessive expansion of cancer‐associated fibroblasts (CAFs) and aberrant extracellular matrix (ECM) deposition, is widely present especially in invasive cancers. The extranodal extension (ENE) of nodal metastasis involves the extension of invasive tumor cells through the lymph node capsule into the perinodal ...
Qian Zhang +6 more
wiley +1 more source
A 3D In Vitro Model of the Human Hepatobiliary Junction
Advanced Science, Volume 13, Issue 39, 13 July 2026.A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield +13 more
wiley +1 more source
Allicin Attenuates Silica‐Induced Pulmonary Fibrosis by Targeting the Serpinb2/NF‐κB Pathway
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.Allicin ameliorates silica‐induced pulmonary fibrosis by suppressing ferroptosis via the Serpinb2/NF‐κB pathway, highlighting its therapeutic potential for silicosis. ABSTRACT Silica‐induced pulmonary fibrosis is a debilitating condition with limited therapeutic options.
Zhou Sijing +6 more
wiley +1 more source
The FEBS Journal, Volume 293, Issue 13, Page 3788-3813, July 2026.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
An update on the landscape of collagen bioactive fragments
The FEBS Journal, Volume 293, Issue 13, Page 4064-4084, July 2026.The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley +1 more source
Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health
The FEBS Journal, Volume 293, Issue 13, Page 3881-3898, July 2026.Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin +2 more
wiley +1 more source
The FEBS Journal, Volume 293, Issue 13, Page 3758-3787, July 2026.The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka +3 more
wiley +1 more source
Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues
Advanced Science, Volume 13, Issue 33, 15 June 2026.Electrical stimulation (ESTIM) enhances vasculature formation in engineered human tissues. In 3D endothelial‐fibroblast constructs, conditioning with ESTIM promotes the formation of dense and highly branched networks that rapidly anastomose with mouse vasculature when implanted in vivo. Vessels formed under ESTIM are importantly functionally perfusable.
Katarzyna A. Grzelak +6 more
wiley +1 more source