Results 41 to 50 of about 5,280 (176)

In-silico definition of the Drosophila melanogaster matrisome

Matrix Biology Plus, 2019
ABSTRACTThe extracellular matrix (ECM) is an assembly of hundreds of proteins that structurally supports the cells it surrounds and biochemically regulates their functions.Drosophilahas emerged as a powerful model organism to study fundamental mechanisms underlying ECM protein secretion, ECM assembly, and ECM roles in pathophysiological processes ...
Martin N. Davis, Sally Horne-Badovinac, Alexandra Naba   +2 more
openaire   +3 more sources

Inflammation-related citrullination of matrisome proteins in human cancer

Frontiers in Oncology, 2022
IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM). PADs are abundantly expressed in human cancer cells.
Pekka Rappu, Ujjwal Suwal, Elina Siljamäki, Jyrki Heino   +3 more
openaire   +4 more sources

Differential regulation of extracellular matrix protein expression in carcinoma-associated fibroblasts by TGF-β1 regulates cancer cell spreading but not adhesion [PDF]

, 2014
Cancer progression is characterized by a complex reciprocity between neoplastic epithelium and adjacent stromal cells. In ductal carcinoma in situ (DCIS) of the breast, both reduced stromal decorin expression and myxoid stroma are correlated with ...
Bracke, Marc, Braems, Geert, Cocquyt, Veronique, De Vlieghere, Elly, De Wever, Olivier, Denys, Hannelore, Lambein, Kathleen, Libbrecht, Louis, LIMAME, RIDHA, Van Bockstal, Mieke, Van den Broecke, Rudy, Van Gele, Mireille   +11 more
core   +3 more sources

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients [PDF]

, 2016
We have previously identified UMP-CMP kinase (CMPK1) as a prognostic marker for triple negative breast cancer (TNBC) by mass spectrometry (MS).
Brask, J.B. (Julie Benedicte), Deurzen, C.H.M. (Carolien) van, Foekens, J.A. (John), Foekens, R. (Renée), Liu, N.Q. (Ning Qing), Look, M.P. (Maxime), Marchi, T. (Tommaso) de, Martens, J.W.M. (John), Smid, M. (Marcel), Span, P.N. (Paul), Sweep, F.C. (Fred), Timmermans, A.M. (Annemieke), Timmermans-Wielenga, V. (Vera), Trapman-Jansen, A.M.A.C. (Anita M.A.C.), Umar, A. (Arzu)   +14 more
core   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Proteomic differences between native and tissue-engineered tendon and ligament [PDF]

, 2016
Tendons and ligaments (T/Ls) play key roles in the musculoskeletal system, but they are susceptible to traumatic or age‐related rupture, leading to severe morbidity as well as increased susceptibility to degenerative joint diseases such as osteoarthritis.
Adirim, Ahmed, Bancroft, Bayer, Benjamin, Bergman, Beynnon, Birch, Burt, Butler, Calve, Canty, Canty, Cimino, Clegg, Comerford, Daniel, Farndale, Franceschini, Funakoshi, Hagerty, Herchenhan, Herchenhan, Hynes, Kapacee, Kapacee, Little, Maffulli, Maffulli, Mastrokalos, Naba, Paxton, Paxton, Peffers, Peffers, Raspanti, Rees, Reichenberg, Robertson, Rodrigues, Singer, Smith, Spindler, Strickland, Thorpe, Vogel, Woo, Young, Zhang   +48 more
core   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, EarlyView.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

RGTA® or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients [PDF]

, 2017
The importance of extracellular matrix (ECM) integrity in maintaining normal tissue function is highlighted by numerous pathologies and situations of acute and chronic injury associated with dysregulation or destruction of ECM components. Heparan sulfate
Barritault, D. (Denis), Baudouin, C. (Christophe), Desgranges, P. (Pascal), Gilbert-Sirieix, M. (Marie), Neck, J.W. (Han) van, Papy-Garcia, D. (Dulce), Rice, K.L. (Kim Lee), Saffar, J.-L. (Jean-Louis), Siñeriz, F. (Fernando), Zakine, G. (Gilbert)   +9 more
core   +2 more sources