Results 51 to 60 of about 4,103 (166)
Proteomic Identification of a Gastric Tumor ECM Signature Associated With Cancer Progression
Frontiers in Molecular Biosciences, 2022 The extracellular matrix (ECM) plays an undisputable role in tissue homeostasis and its deregulation leads to altered mechanical and biochemical cues that impact cancer development and progression.
Ana M. Moreira +25 more
doaj +1 more source
eLife, 2021 Collagen-rich tissues have poor reparative capacity that predisposes to common age-related disorders such as osteoporosis and osteoarthritis. We used in vivo pulsed SILAC labelling to quantify new protein incorporation into cartilage, bone, and skin of ...
Yoanna Ariosa-Morejon +7 more
doaj +1 more source
Fibroblast subtypes define a metastatic matrisome in breast cancer [PDF]
JCI Insight, 2020 Small primary breast cancers can show surprisingly high potential for metastasis. Clinical decision-making for tumor aggressiveness, including molecular profiling, relies primarily on analysis of the cancer cells. Here we show that this analysis is insufficient — that the stromal microenvironment of the primary tumor plays a key ...
Heather M. Brechbuhl +12 more
openaire +2 more sources
PLoS ONE, 2022 The extracellular matrix in the tumour microenvironment can regulate cancer cell growth and progression. A pan-cancer analysis of TCGA data from 30 cancer types, identified the top 5% of matrisome genes with amplifications or deletions in their copy ...
Keerthi Harikrishnan +2 more
doaj +2 more sources
Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis
Frontiers in Cell and Developmental Biology, 2021 Skin aging is a physiological issue that is still relatively poorly understood. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging.
Mansheng Li +16 more
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The cochlear matrisome: Importance in hearing and deafness
Matrix BiologyThe extracellular matrix (ECM) consists in a complex meshwork of collagens, glycoproteins, and proteoglycans, which serves a scaffolding function and provides viscoelastic properties to the tissues. ECM acts as a biomechanical support, and actively participates in cell signaling to induce tissular changes in response to environmental forces and soluble
Pressé, Mary +2 more
openaire +2 more sources
FEBS Open Bio, 2023 The extracellular matrix (ECM) plays a vital role in the progression and metastasis of glioma and is an important part of the tumor microenvironment. The matrisome is composed of ECM components and related proteins. There have been several studies on the
Hao Yu +3 more
doaj +1 more source
Frontiers in Oncology, 2023 IntroductionThe composition and remodelling of the extracellular matrix (ECM) are important factors in the development and progression of cancers, and the ECM is implicated in promoting tumour growth and restricting anti-tumour therapies through multiple
Helen F. Titmarsh +13 more
doaj +1 more source
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion
Cell Reports, 2022 Summary: In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (CAFs) can both promote and suppress tumor progression.
Elizabeth R. Murray +26 more
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Matrisome enrichment differs between SDS and Triton decellularization.
, 2023 Matrisome enrichment differs between SDS and Triton decellularization.
Laetitia M. O. de Kort (11529873) +7 more
core +1 more source