Results 51 to 60 of about 3,090 (127)
Rare loss-of-function variants in matrisome genes are enriched in Ebstein’s anomaly
HGG AdvancesSummary: Ebstein’s anomaly, a rare congenital heart disease, is distinguished by the failure of embryological delamination of the tricuspid valve leaflets from the underlying primitive right ventricle myocardium. Gaining insight into the genetic basis of
Zhou Zhou +7 more
doaj +1 more source
Quantitative proteomic characterization of lung tissue in idiopathic pulmonary fibrosis
Clinical Proteomics, 2019 Background Idiopathic pulmonary fibrosis (IPF) is a progressive, eventually fatal disease. IPF is characterized by excessive accumulation of the extracellular matrix (ECM) in the alveolar parenchyma and progressive lung scarring.
Yaqiong Tian +10 more
doaj +1 more source
First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria
Advanced Science, Volume 13, Issue 32, 9 June 2026.We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena +5 more
wiley +1 more source
Acute Lung Injury: From Molecular Circuits to System‐Level Therapeutics
MedComm, Volume 7, Issue 6, June 2026.This visual summary illustrates the paradigm shift from linear pathways to network medicine in ALI. Three interconnected circuits—innate immunity, immunometabolism, and cell death (PANoptosis)—drive disease progression under multiorgan crosstalk (gut–lung, brain–lung).
Yaoli Hou +10 more
wiley +1 more source
Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues
Advanced Materials, Volume 38, Issue 27, 14 May 2026.A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad +6 more
wiley +1 more source
The extracellular matrix phenome across species
Matrix Biology Plus, 2020 Extracellular matrices are essential for cellular and organismal function. Recent genome-wide and phenome-wide association studies started to reveal a broad spectrum of phenotypes associated with genetic variants.
Cyril Statzer, Collin Y. Ewald
doaj +1 more source
Extracellular matrix protein composition dynamically changes during murine forelimb development
iScienceSummary: The extracellular matrix (ECM) is an integral part of multicellular organisms, connecting different cell layers and tissue types. During morphogenesis and growth, tissues undergo substantial reorganization.
Kathryn R. Jacobson +9 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2019 During early avian development, primordial germ cells (PGC) are highly migratory, moving from the central area pellucida of the blastoderm to the anterior extra-embryonic germinal crescent.
David J. Huss +14 more
doaj +1 more source
Frontiers in Cellular NeuroscienceThe maturation of brain microvascular endothelial cells leads to the formation of a tightly sealed monolayer, known as the blood–brain barrier (BBB). The BBB damage is associated with the pathogenesis of age-related neurodegenerative diseases including ...
Yasuteru Inoue +11 more
doaj +1 more source
The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells
Frontiers in Cell and Developmental BiologyRadiotherapy of prostate cancer (PC) can lead to the acquisition of radioresistance through molecular mechanisms that involve, in part, cell adhesion-mediated signaling.
Ivana Samaržija +18 more
doaj +1 more source