Results 51 to 60 of about 5,280 (176)

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition [PDF]

, 2016
This study was funded by the BBSRC (BB/K008412/1)
A Franceschini, A Heinz, A Heinz, AA Biewener, B Kim, B Poulet, CT Thorpe, CT Thorpe, CT Thorpe, D Little, ER Ely, GA Lichtwark, H Mi, HL Birch, HL Birch, J Halper, J Melrose, JA Vizcaíno, JF Innes, JL Ireland, JM Whitelock, K Halasz, KE Kadler, KM Heinemeier, L Svensson, M Peffers, MJ Peffers, MJ Peffers, PE Hall, PJ Roughley, PPY Lui, PR Stephens, R Strocchi, RAE Clayton, RC Dwivedi, RK Smith, RM Korol, RO Hynes, S Kalamajski, SG Rees, SH Taylor, T Can, TM Grant, TM Ritty, X Liu, Y Kasashima, Y Sun, Y-L Sun   +47 more
core   +4 more sources

Adherens junction protein expression is associated with poor response to neoadjuvant FLOT chemotherapy and pro‐inflammatory tumor microenvironment in esophageal adenocarcinoma

International Journal of Cancer, EarlyView.
What's New? Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor survival and variable response to perioperative chemotherapy. Although histopathological features correlate with outcomes, the relationship specifically between adherens junction (AJ) protein expression and treatment response in EAC remains uncertain.
Bastian Grothey, Heike Löser, Tillmann Bedau, Wolfgang Schröder, Christiane J. Bruns, Thomas Zander, Max Krämer, Reinhard Büttner, Alexander Quaas   +8 more
wiley   +1 more source

The cochlear matrisome: Importance in hearing and deafness

Matrix Biology
The extracellular matrix (ECM) consists in a complex meshwork of collagens, glycoproteins, and proteoglycans, which serves a scaffolding function and provides viscoelastic properties to the tissues. ECM acts as a biomechanical support, and actively participates in cell signaling to induce tissular changes in response to environmental forces and soluble
Pressé, Mary, Malgrange, Brigitte, Delacroix, Laurence   +2 more
openaire   +2 more sources

Pipeline for precise insoluble matrisome coverage in tissue extracellular matrices

Frontiers in Bioengineering and Biotechnology, 2023
The extracellular matrix (ECM) is assembled by hundreds of proteins orchestrating tissue patterning and surrounding cell fates via the mechanical–biochemical feedback loop. Aberrant ECM protein production or assembly usually creates pathological niches eliciting lesions that mainly involve fibrogenesis and carcinogenesis.
Wei Chen, Wei Chen, Wen Zhang, Wen Zhang, Ning Zhang, Ning Zhang, Shuyan Chen, Shuyan Chen, Tao Huang, Tao Huang, Hong You, Hong You   +11 more
openaire   +3 more sources

The Pathway Coexpression Network: Revealing pathway relationships. [PDF]

, 2018
A goal of genomics is to understand the relationships between biological processes. Pathways contribute to functional interplay within biological processes through complex but poorly understood interactions.
A Alexeyenko, A Alexeyenko, A Brazma, A Burns, A Kumar, A Lewin, A Liberzon, A Naba, A Pujol, A Subramanian, A Thakur, A Zambrano, AA Sharov, AL Barabási, AL Barabási, B Efron, B Schreitmüller, C Ogris, CF Schaefer, Christina S. Leslie, Claire Green, D Croft, D Izawa, D Merico, D Nishimura, D Paris, D Warde-Farley, DR Rhodes, DR Rhodes, E Clough, E Eisenberg, FH Duits, FX Lepelletier, G Stelzer, Gabriel Altschuler, GE Landreth, GM Altschuler, GV Glazko, H Naeem, H Pearson, H Yan, HJM de Jonge, HR Frost, HR Frost, HS Le, J Caltagarone, J Dutkowski, J Pevsner, J Rung, J Schäfer, J Seita, J Weinstein, J Weinstein, JC Vivar, JF Rual, JH Hung, JS Miners, JT Leek, Katjuša Koler, KG Becker, L Matthews, L Thorrez, LG Bodea, M Ashburner, M de Jager, M Kanehisa, M Kanehisa, M Kanehisa, M Kramer, M Lukk, M Morawski, M Schena, ME Orcholski, MJ Macias, MJ Végh, MK Sethi, MM Almeida-de Macedo, MMM Wilhelmus, MN McCall, MN McCall, MN McCall, O Berezovska, O Ledoit, P Di Lena, P Scheltens, PL McGeer, R Isserlin, R Sherrington, R von Bernhardi, RJ Kelleher, RM Ewing, Rudolph E. Tanzi, S Bauer, S Catricala, S Davis, S Draghici, S Falcon, S Gaubatz, S Grossmann, S Lu, S Maere, S Ranganathan, Sokratis Kariotis, SY Kim, T Barrett, T Liptak, T McCormack, T Wang, TM Loughin, U Hassler, U Stelzl, V Popovici, VK Ramanan, W Fujibuchi, W Zhang, Wenbin Wei, Winston Hide, WR Markesbery, WS Liang, WT Barry, Y Benjamini, Y Huang, Y Kong, Y Li, Y Liu, Y Lu, Y Pritykin, Y Tan, Y Yamaguchi, Y Yu, Yered Pita-Juárez   +130 more
core   +4 more sources

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

A linear mixed model approach to gene expression-tumor aneuploidy association studies. [PDF]

, 2019
Aneuploidy, defined as abnormal chromosome number or somatic DNA copy number, is a characteristic of many aggressive tumors and is thought to drive tumorigenesis.
Balanis, Nikolas G, Eskin, Eleazar, Graeber, Thomas G, Yao, Douglas W   +3 more
core  

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Regulation of the E/I-balance by the neural matrisome

Frontiers in Molecular Neuroscience, 2023
In the mammalian cortex a proper excitatory/inhibitory (E/I) balance is fundamental for cognitive functions. Especially γ-aminobutyric acid (GABA)-releasing interneurons regulate the activity of excitatory projection neurons which form the second main class of neurons in the cortex.
Müller-Bühl, Cornelius (Dr. rer. nat.), Wegrzyn, David (Dr. rer. nat.), Bauch, Juliane (Dr. rer. nat.), Faissner, Andreas (Prof. Dr.)   +3 more
openaire   +4 more sources