A glitch in the matrix: organ-specific matrisomes in metastatic niches [PDF]
Trends in Cell Biology, 2022 Modification of the extracellular matrix (ECM) is a critical aspect of developing a metastasis-supportive organ niche. Recent work investigating ECM changes that facilitate metastasis has revealed ways in which different metastatic organ niches are similar as well as the distinct characteristics that make them unique.
Sarah K. Deasy, Neta Erez
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Extracellular matrix gene expression signatures as cell type and cell state identifiers
Matrix Biology Plus, 2021 Transcriptomic signatures based on cellular mRNA expression profiles can be used to categorize cell types and states. Yet whether different functional groups of genes perform better or worse in this process remains largely unexplored.
Fabio Sacher +3 more
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Characterizing the extracellular matrix transcriptome of cervical, endometrial, and uterine cancers
Matrix Biology Plus, 2022 Increasingly, the matrisome, a set of proteins that form the core of the extracellular matrix (ECM) or are closely associated with it, has been demonstrated to play a key role in tumor progression.
Carson J. Cook +4 more
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Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts [PDF]
Matrix Biology, 2022 ABSTRACT The circadian clock in tendon regulates the daily rhythmic synthesis of collagen-I and the appearance and disappearance of small-diameter collagen fibrils in the extracellular matrix. How the fibrils are assembled and removed is not fully understood. Here, we first showed that the collagenase, membrane type I-
Ching-Yan Chloé Yeung +14 more
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Table_2_Inflammation-related citrullination of matrisome proteins in human cancer.xlsx
, 2022 IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Elina Siljamäki (279419) +3 more
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Tissue, age, sex, and disease patterns of matrisome expression in GTEx transcriptome data
Scientific Reports, 2021 The extracellular matrix (ECM) has historically been explored through proteomic methods. Whether or not global transcriptomics can yield meaningful information on the human matrisome is unknown. Gene expression data from 17,382 samples across 52 tissues,
Tim O. Nieuwenhuis +3 more
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Challenges and Opportunities Modeling the Dynamic Tumor Matrisome
BME Frontiers, 2023 We need novel strategies to target the complexity of cancer and, particularly, of metastatic disease. As an example of this complexity, certain tissues are particularly hospitable environments for metastases, whereas others do not contain fertile microenvironments to support cancer cell growth. Continuing evidence that the extracellular matrix (ECM) of
Peyton, Shelly R. +2 more
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Table_1_Inflammation-related citrullination of matrisome proteins in human cancer.xlsx
, 2022 IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Elina Siljamäki (279419) +3 more
core +1 more source
Image_1_Inflammation-related citrullination of matrisome proteins in human cancer.jpeg
, 2022 IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Elina Siljamäki (279419) +3 more
core +1 more source
Extracellular Matrix-Oriented Proteomic Analysis of Periodontal Ligament Under Mechanical Stress
Frontiers in Physiology, 2022 The periodontal ligament (PDL) is a specialized connective tissue that provides structural support to the tooth and is crucial for oral functions. The mechanical properties of the PDL are mainly derived from the tissue-specific composition and structural
Lay Thant +15 more
doaj +1 more source