Results 11 to 20 of about 5,280 (176)
An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease. [PDF]
Aging CellA 14‐protein extracellular matrix aging clock derived from circulating matrisome proteins predicts chronological and biological age across cohorts and biofluids, distinguishes health from disease, and is modulated by rejuvenation interventions in mice, enabling the nomination of potential ECM targets for drug discovery to promote healthy aging ...
Coenen L +4 more
europepmc +2 more sources
The Matrisome, Inflammation, and Liver Disease [PDF]
Seminars in Liver Disease, 2020 AbstractChronic fatty liver disease is common worldwide. This disease is a spectrum of disease states, ranging from simple steatosis (fat accumulation) to inflammation, and eventually to fibrosis and cirrhosis if untreated. The fibrotic stage of chronic liver disease is primarily characterized by robust accumulation of extracellular matrix (ECM ...
Christine E, Dolin, Gavin E, Arteel
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The liver matrisome – looking beyond collagens [PDF]
JHEP Reports, 2020 The extracellular matrix (ECM) is a diverse microenvironment that maintains bidirectional communication with surrounding cells to regulate cell and tissue homeostasis. The classical definition of the ECM has more recently been extended to include non-fibrillar proteins that either interact or are structurally affiliated with the ECM, termed the ...
Arteel, Gavin E., Naba, Alexandra
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Divide-and-Conquer Matrisome Protein (DC-MaP) Strategy: An MS-Friendly Approach to Proteomic Matrisome Characterization [PDF]
International Journal of Molecular Sciences, 2020 Currently, the extracellular matrix (ECM) is considered a pivotal complex meshwork of macromolecules playing a plethora of biomolecular functions in health and disease beyond its commonly known mechanical role. Only by unraveling its composition can we leverage related tissue engineering and pharmacological efforts. Nevertheless, its unbiased proteomic
Emna Ouni +5 more
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The cartilage matrisome in adolescent idiopathic scoliosis [PDF]
Bone Research, 2020 AbstractThe human spinal column is a dynamic, segmented, bony, and cartilaginous structure that protects the neurologic system and simultaneously provides balance and flexibility. Children with developmental disorders that affect the patterning or shape of the spine can be at risk of neurologic and other physiologic dysfunctions.
Carol A. Wise +10 more
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Comparative proteomic assessment of matrisome enrichment methodologies [PDF]
Biochemical Journal, 2016 The matrisome is a complex and heterogeneous collection of extracellular matrix (ECM) and ECM-associated proteins that play important roles in tissue development and homeostasis. While several strategies for matrisome enrichment have been developed, it is currently unknown how the performance of these different methodologies compares in the proteomic ...
Krasny, L +5 more
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Challenges and Opportunities Modeling the Dynamic Tumor Matrisome
BME Frontiers, 2023 We need novel strategies to target the complexity of cancer and, particularly, of metastatic disease. As an example of this complexity, certain tissues are particularly hospitable environments for metastases, whereas others do not contain fertile microenvironments to support cancer cell growth. Continuing evidence that the extracellular matrix (ECM) of
Peyton, Shelly R. +2 more
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The kidney matrisome in health, aging, and disease
Kidney International, 2022 Dysregulated extracellular matrix is the hallmark of fibrosis, and it has a profound impact on kidney function in disease. Furthermore, perturbation of matrix homeostasis is a feature of aging and is associated with declining kidney function. Understanding these dynamic processes, in the hope of developing therapies to combat matrix dysregulation ...
Lausecker, Franziska +2 more
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The Matrisome Genes From Hepatitis B–Related Hepatocellular Carcinoma Unveiled [PDF]
Hepatology Communications, 2021 Chronic hepatitis B virus (HBV) infection changes the composition of the extracellular matrix (ECM) and enables the onset and progression of hepatocellular carcinoma (HCC). The ensemble of ECM proteins and associated factors is a major component of the tumor microenvironment.
Wei Chen +8 more
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A core matrisome gene signature predicts cancer outcome [PDF]
British Journal of Cancer, 2018 Accumulating evidence implicates the tumour stroma as an important determinant of cancer progression but the protein constituents relevant for this effect are unknown. Here we utilised a bioinformatics approach to identify an extracellular matrix (ECM) gene signature overexpressed in multiple cancer types and strongly predictive of adverse outcome.Gene
Yuzhalin, A +4 more
openaire +3 more sources