Results 11 to 20 of about 3,090 (127)

Pan-Cancer analysis of the expression and regulation of matrisome genes across 32 tumor types

Matrix Biology Plus, 2019
The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines and growth factors collectively referred to as the matrisome.
Valerio Izzi, Juho Lakkala, Raman Devarajan, Anni Kääriäinen, Jarkko Koivunen, Ritva Heljasvaara, Taina Pihlajaniemi   +6 more
doaj   +3 more sources

Microgravity Effects on the Matrisome

Cells, 2021
Gravity is fundamental factor determining all processes of development and vital activity on Earth. During evolution, a complex mechanism of response to gravity alterations was formed in multicellular organisms.
Ludmila Buravkova, Irina Larina, Elena Andreeva, Anatoly Grigoriev   +3 more
doaj   +3 more sources

Alterations of Matrisome Gene Expression in Naturally Aged and Photoaged Human Skin In Vivo

Biomolecules
The main component of human skin is a collagen-rich extracellular matrix (ECM), known as the matrisome. The matrisome is essential for maintaining the structural integrity and mechanical properties of the skin.
Yan Yan, Hehui Quan, Chunfang Guo, Zhaoping Qin, Taihao Quan   +4 more
doaj   +3 more sources

Atlas of mildly and highly insoluble matrisome driving liver fibrosis

Frontiers in Pharmacology
The excessive deposition and cross-linking of core matrisome components typically result in abnormal remodeling of the extracellular matrix (ECM), leading to increased liver stiffness and worsening liver fibrosis.
Wen Zhang, Wen Zhang, Wen Zhang, Ning Zhang, Ning Zhang, Ning Zhang, Wenyue Wu, Wenyue Wu, Wenyue Wu, Hong Li, Hong Li, Hong Li, Hong Li, Hong You, Hong You, Hong You, Wei Chen, Wei Chen, Wei Chen, Wei Chen, Wei Chen   +20 more
doaj   +3 more sources

Characterizing the extracellular matrix transcriptome of cervical, endometrial, and uterine cancers

Matrix Biology Plus, 2022
Increasingly, the matrisome, a set of proteins that form the core of the extracellular matrix (ECM) or are closely associated with it, has been demonstrated to play a key role in tumor progression.
Carson J. Cook, Andrew E. Miller, Thomas H. Barker, Yanming Di, Kaitlin C. Fogg   +4 more
doaj   +1 more source

Tissue, age, sex, and disease patterns of matrisome expression in GTEx transcriptome data

Scientific Reports, 2021
The extracellular matrix (ECM) has historically been explored through proteomic methods. Whether or not global transcriptomics can yield meaningful information on the human matrisome is unknown. Gene expression data from 17,382 samples across 52 tissues,
Tim O. Nieuwenhuis, Avi Z. Rosenberg, Matthew N. McCall, Marc K. Halushka   +3 more
doaj   +1 more source

Novel prognostic matrisome-related gene signature of head and neck squamous cell carcinoma

Frontiers in Cell and Developmental Biology, 2022
Background: Head and neck squamous cell carcinoma (HNSCC) is a common malignancy of the mucosal epithelium of the oral cavity, pharynx, and larynx.
Chao Huang, Chao Huang, Yun Liang, Yun Liang, Yi Dong, Yi Dong, Li Huang, Anlei Li, Ran Du, Ran Du, Hao Huang, Hao Huang, Hao Huang, Hao Huang   +13 more
doaj   +1 more source

The liver matrisome – looking beyond collagensKey points

JHEP Reports, 2020
Summary: The extracellular matrix (ECM) is a diverse microenvironment that maintains bidirectional communication with surrounding cells to regulate cell and tissue homeostasis.
Gavin E. Arteel, Alexandra Naba
doaj   +1 more source

Extracellular Matrix-Oriented Proteomic Analysis of Periodontal Ligament Under Mechanical Stress

Frontiers in Physiology, 2022
The periodontal ligament (PDL) is a specialized connective tissue that provides structural support to the tooth and is crucial for oral functions. The mechanical properties of the PDL are mainly derived from the tissue-specific composition and structural
Lay Thant, Lay Thant, Lay Thant, Masaru Kaku, Yoshito Kakihara, Masaru Mizukoshi, Megumi Kitami, Megumi Kitami, Moe Arai, Kohei Kitami, Daiki Kobayashi, Yutaka Yoshida, Takeyasu Maeda, Isao Saito, Katsumi Uoshima, Makio Saeki   +15 more
doaj   +1 more source

The in-silico characterization of the Caenorhabditis elegans matrisome and proposal of a novel collagen classification

Matrix Biology Plus, 2019
Proteins are the building blocks of life. While proteins and their localization within cells and sub-cellular compartments are well defined, the proteins predicted to be secreted to form the extracellular matrix - or matrisome - remain elusive in the ...
Alina C. Teuscher, Elisabeth Jongsma, Martin N. Davis, Cyril Statzer, Jan M. Gebauer, Alexandra Naba, Collin Y. Ewald   +6 more
doaj   +1 more source