Results 11 to 20 of about 4,103 (166)

The liver matrisome – looking beyond collagensKey points [PDF]

JHEP Reports, 2020
Summary: The extracellular matrix (ECM) is a diverse microenvironment that maintains bidirectional communication with surrounding cells to regulate cell and tissue homeostasis.
Gavin E. Arteel, Alexandra Naba
doaj   +4 more sources

In-silico definition of the Drosophila melanogaster matrisome

Matrix Biology Plus, 2019
The extracellular matrix (ECM) is an assembly of hundreds of proteins that structurally supports the cells it surrounds and biochemically regulates their functions.
Martin N. Davis, Sally Horne-Badovinac, Alexandra Naba   +2 more
doaj   +4 more sources

The matrisome landscape controlling in vivo germ cell fates

Nature Communications
The developmental fate of cells is regulated by intrinsic factors and the extracellular environment. The extracellular matrix (matrisome) delivers chemical and mechanical cues that can modify cellular development.
Aqilah Amran, Lara Pigatto, Johanna Farley, Rasoul Godini, Roger Pocock, Sandeep Gopal   +5 more
doaj   +5 more sources

The Matrisome Genes From Hepatitis B–Related Hepatocellular Carcinoma Unveiled

Hepatology Communications, 2021
Chronic hepatitis B virus (HBV) infection changes the composition of the extracellular matrix (ECM) and enables the onset and progression of hepatocellular carcinoma (HCC).
Wei Chen, Romain Desert, Xiaodong Ge, Hui Han, Zhuolun Song, Sukanta Das, Dipti Athavale, Hong You, Natalia Nieto   +8 more
doaj   +2 more sources

Comparative proteomic assessment of matrisome enrichment methodologies [PDF]

Biochemical Journal, 2016
The matrisome is a complex and heterogeneous collection of extracellular matrix (ECM) and ECM-associated proteins that play important roles in tissue development and homeostasis. While several strategies for matrisome enrichment have been developed, it is currently unknown how the performance of these different methodologies compares in the proteomic ...
Krasny, L, Paul, A, Wai, P, Howard, BA, Natrajan, RC, Huang, PH   +5 more
openaire   +5 more sources

Matrisome Deregulation in Ovarian Cancer Metastasis [PDF]

Proceedings of IMPRS, 2020
Background and Hypothesis: Over 75% of ovarian cancer (OC) patients present with metastasis upon initial diagnosis. Since most are treated for metastatic disease, it is crucial that developing therapies target metastasis. Our analysis of OC transcriptomic changes revealed key changes in the matrisome.
Jessica Tedrow, Ji Wang, Anirban Mitra
core   +4 more sources

Inflammation-related citrullination of matrisome proteins in human cancer

Frontiers in Oncology, 2022
IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Pekka Rappu, Ujjwal Suwal, Elina Siljamäki, Jyrki Heino   +3 more
doaj   +4 more sources

Functional Bioinformatics Analyses of the Matrisome and Integrin Adhesome

, 2020
The extracellular matrix (ECM) is the noncellular compartment of living organisms and is formed of a complex network of cross-linked proteins, which is collectively known as the matrisome. Apart from providing the structure for an organism, cells interact and thereby communicate with the ECM. Cells interact with their surrounding ECM using cell-surface
Edward Roy Horton, Horton, Edward Roy
openaire   +4 more sources

Pan-Cancer Analysis of the Genomic Alterations and Mutations of the Matrisome [PDF]

Cancers, 2020
The extracellular matrix (ECM) is a master regulator of all cellular functions and a major component of the tumor microenvironment. We previously defined the “matrisome” as the ensemble of genes encoding ECM proteins and proteins modulating ECM structure or function.
Valerio Izzi, Martin N. Davis, Alexandra Naba   +2 more
openaire   +5 more sources

Targets in the Tumour Matrisome to Promote Cancer Therapy Response [PDF]

Cancers
The extracellular matrix (ECM) is composed of complex fibrillar proteins, proteoglycans, and macromolecules, generated by stromal, immune, and cancer cells. The components and organisation of the matrix evolves as tumours progress to invasive disease and metastasis.
Siti Munira Abd Jalil, Jack C. Henry, Angus J. M. Cameron   +2 more
core   +4 more sources