Results 21 to 30 of about 1,083,664 (336)

Appearance of fibronectin during the differentiation of cartilage, bone, and bone marrow. [PDF]

, 1981
Fibronectin has been localized by indirect immunofluorescence during the various phases of endochondral bone formation in response to subcutaneously implanted demineralized bone matrix.
Reddi, AH, Weiss, RE
core   +1 more source

Collagens - structure, function and biosynthesis. [PDF]

, 2003
The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions.
Aigner, T, Gelse, K, Poschl, E
core   +1 more source

Matrix metalloproteinases at key junctions in the pathomechanism of stroke [PDF]

, 2011
Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Amento, Ang, Asahi, Asahi, Barkho, Bergers, Bini, Cao, Cardone, Chinopoulos, Cunningham, Denker, Dong, Fabunmi, Fisher, Frisch, Galis, Galis, Galis, Galis, Gidday, Godin, Gross, Gu, Gu, Gurney, Haas, Haddad, Halliwell, Hamann, Harkness, Herman, Hornig, Hyslop, Itoh, Kumura, Langton, Lapchak, Larsen, Lee, Lelongt, Loftus, Lucivero, Luttun, McQuibban, Meredith, Montaner, Montaner, Nagase, Nagel, Nagy, Nagy, Nikkari, Pagenstecher, Qi, Rajagopalan, Ramos, Rekhter, Rolfe, Romanic, Rosell, Rosenberg, Rosenberg, Rosenberg, Rosenberg, Sarén, Sato, Seo, Shrivastava, Shubayev, Siao, Sole, Sottrup, Sternlicht, Strongin, Sukhova, Suzuki, Suzuki, Svedin, Tsuji, Turner, Van, Vogel, Wang, Wang, Webersinke, Yepes, Ying, Zhang, Zhang, Zhang, Zhao   +91 more
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PU.1 controls fibroblast polarization and tissue fibrosis [PDF]

, 2019
Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant amounts of extracellular matrix, which induces scarring and organ failure.
Beyer, Christian, Boykin, David W., Butter, Falk, Chen, Chih-Wei, Daniel, Christoph, Dees, Clara, Distler, Jörg H. W., Distler, Oliver, Ekici, Arif, Finotto, Susetta, Gay, Steffen, Gelse, Kolja, Jüngel, Astrid, Kaplan, Mark H., Karouzakis, Emmanuel, Kiener, Hans P., Kremer, Andreas E., Kreuter, Alexander, Luber, Markus, Maier, Christiane, Matei, Alexandru-Emil, Naschberger, Elisabeth, Nutt, Stephen L., Pachera, Elena, Poon, Gregory M. K., Ramming, Andreas, Rauber, Simon, Schett, Georg, Soare, Alina, Sticherling, Michael, Stürzl, Michael, Uebe, Steffen, Weber, Stefanie, Wohlfahrt, Thomas   +33 more
core   +1 more source

Enzymatic Digestion of Hyaluronan-Based Brain Extracellular Matrix in vivo Can Induce Seizures in Neonatal Mice

Frontiers in Neuroscience, 2019
It is well-known that hyaluronic acid (HA) as a component of brain extracellular matrix (ECM) plays a pivotal role in the nervous system and is involved in synaptic plasticity changes in vascular cognitive impairment and dementia.
Alena Balashova, Vladimir Pershin, Vladimir Pershin, Olga Zaborskaya, Olga Zaborskaya, Natalia Tkachenko, Natalia Tkachenko, Andrey Mironov, Andrey Mironov, Evgeny Guryev, Evgeny Guryev, Leonid Kurbatov, Murat Gainullin, Murat Gainullin, Irina Mukhina, Irina Mukhina   +15 more
doaj   +1 more source

Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes. [PDF]

, 2018
Basement membranes are extracellular matrices essential for embryonic development in animals. Peroxidasins are extracellular peroxidases implicated in the unique sulfilimine cross-links between type IV basement membrane collagens. Loss of function in the
Chisholm, Andrew D, Gotenstein, Jennifer R, Ho, Tiffany W, Koo, Cassidy C   +3 more
core   +2 more sources

Fragment-based virtual screening identifies a first-in-class preclinical drug candidate for Huntington’s disease

Scientific Reports, 2022
Currently, there are no therapies available to modify the disease progression of Huntington’s disease (HD). Recent clinical trial failures of antisense oligonucleotide candidates in HD have demonstrated the need for new therapeutic approaches.
Simon Marius Galyan, Collin Y. Ewald, Xavier Jalencas, Shyam Masrani, Selin Meral, Jordi Mestres   +5 more
doaj   +1 more source

Decellularized Tissues for Wound Healing: Towards Closing the Gap Between Scaffold Design and Effective Extracellular Matrix Remodeling

Frontiers in Bioengineering and Biotechnology, 2022
The absence or damage of a tissue is the main cause of most acute or chronic diseases and are one of the appealing challenges that novel therapeutic alternatives have, in order to recover lost functions through tissue regeneration.
Víctor Alfonso Solarte David, Víctor Alfonso Solarte David, Viviana Raquel Güiza-Argüello, Martha L. Arango-Rodríguez, Claudia L. Sossa, Claudia L. Sossa, Silvia M. Becerra-Bayona   +6 more
doaj   +1 more source

Modeling cell movement in anisotropic and heterogeneous network tissues [PDF]

, 2007
Cell motion and interaction with the extracellular matrix is studied deriving a kinetic model and considering its diffusive limit. The model takes into account of chemotactic and haptotactic effects, and obtains friction as a result of the interactions ...
Chauviere, A., Hillen, T., Preziosi, Luigi   +2 more
core   +1 more source

Cell surface localization of tissue transglutaminase is dependent on a fibronectin-binding site in its N-terminal beta-sandwich domain [PDF]

, 1999
Increasing evidence indicates that tissue transglutaminase (tTG) plays a role in the assembly and remodeling of extracellular matrices and promotes cell adhesion.
Aeschlimann, D, Cox, A, Gaudry, CA, Griffin, M, Smith, C, Verderio, E   +5 more
core   +1 more source