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The Functional Role of Extracellular Matrix Proteins in Cancer
Cancers, 2022 Simple Summary Extracellular matrix is a three-dimensional network of macromolecules that provide structural and biochemical support to surrounding cells. Extracellular matrix plays a critical role in the development and progression of cancer.
N. Popova, M. Jücker
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The Evolution of Extracellular Matrix [PDF]
Molecular Biology of the Cell, 2010 We present a perspective on the molecular evolution of the extracellular matrix (ECM) in metazoa that draws on research publications and data from sequenced genomes and expressed sequence tag libraries. ECM components do not function in isolation, and the biological ECM system or “adhesome” also depends on posttranslational processing enzymes, cell ...
Özbek, S +4 more
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Folia Histochemica et Cytobiologica, 2022 INTRODUCTION: Cardiovascular diseases were defined as coronary artery, cerebrovascular, or peripheral arterial disease. Hyperhomocysteinemia (Hhcy) is an independent risk factor of cardiovascular diseases, including atherosclerosis.
Fouzia Zerrouk +9 more
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Whole organism profiling of the Timp gene family
Matrix Biology Plus, 2023 Tissue inhibitor of metalloproteinases (TIMPs/Timps) are an endogenous family of widely expressed matrisome-associated proteins that were initially identified as inhibitors of matrix metalloproteinase activity (Metzincin family proteases).
David Peeney +8 more
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The Extracellular Matrix in Skin Inflammation and Infection
Frontiers in Cell and Developmental Biology, 2021 The extracellular matrix (ECM) is an integral component of all organs and plays a pivotal role in tissue homeostasis and repair. While the ECM was long thought to mostly have passive functions by providing physical stability to tissues, detailed ...
Karin Pfisterer +3 more
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The extracellular matrix as modifier of neuroinflammation and remyelination in multiple sclerosis.
Brain : a journal of neurology, 2021 Remyelination failure contributes to axonal loss and progression of disability in multiple sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to an inhibitory lesion microenvironment that prevents recruitment and/or ...
S. Ghorbani, V. Yong
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Longevity interventions temporally scale healthspan in Caenorhabditis elegans
iScience, 2022 Summary: Human centenarians and longevity mutants of model organisms show lower incidence rates of late-life morbidities than the average population.
Cyril Statzer +3 more
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Biology Open, 2017 Cell polarity has a fundamental role in shaping the morphology of cells and growing tissues. Polarity is commonly thought to be established in response to extracellular signals.
Artal Moreno-Fortuny +3 more
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Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy
Frontiers in Molecular Biosciences, 2020 Solid tumors are complex organ-like structures that consist not only of tumor cells but also of vasculature, extracellular matrix (ECM), stromal, and immune cells.
E. Henke, R. Nandigama, S. Ergün
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Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism
Frontiers in Oncology, 2021 In recent years, in-depth studies have shown that extracellular matrix stiffness plays an important role in cell growth, proliferation, migration, immunity, malignant transformation, and apoptosis.
Heming Ge +4 more
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