Results 31 to 40 of about 2,626,097 (306)

Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth [PDF]

open access: yes, 1995
Extracellular matrix (ECM) molecules are involved in multiple aspects of cell-to-cell signaling during development and in the adult. In nervous system development, specific recognition processes, e.g., during axonal pathfinding and synaptogenesis involve
Arber, S., P Caroni, S Arber, Caroni, P.
core   +1 more source

Enzymatic Digestion of Hyaluronan-Based Brain Extracellular Matrix in vivo Can Induce Seizures in Neonatal Mice

open access: yesFrontiers in Neuroscience, 2019
It is well-known that hyaluronic acid (HA) as a component of brain extracellular matrix (ECM) plays a pivotal role in the nervous system and is involved in synaptic plasticity changes in vascular cognitive impairment and dementia.
Alena Balashova   +15 more
doaj   +1 more source

SMAD3 mutation in LDS3 causes bone fragility by impairing the TGF-β pathway and enhancing osteoclastogenesis

open access: yesBone Reports, 2022
Loss-of-function mutations in SMAD3 cause Loeys-Dietz syndrome type 3 (LDS3), a rare autosomal-dominant connective tissue disorder characterized by vascular pathology and skeletal abnormalities.
Ahmed El-Gazzar   +12 more
doaj   +1 more source

Computational Modeling of Single-Cell Migration::The Leading Role of Extracellular Matrix Fibers [PDF]

open access: yes, 2012
Cell migration is vitally important in a wide variety of biological contexts ranging from embryonic development and wound healing to malignant diseases such as cancer. It is a very complex process that is controlled by intracellular signaling pathways as
Schlüter, Daniela K.   +4 more
core   +1 more source

Extracellular matrix gene expression signatures as cell type and cell state identifiers

open access: yesMatrix Biology Plus, 2021
Transcriptomic signatures based on cellular mRNA expression profiles can be used to categorize cell types and states. Yet whether different functional groups of genes perform better or worse in this process remains largely unexplored.
Fabio Sacher   +3 more
doaj   +1 more source

Cellular responses to dental extracellular matrix molecules [PDF]

open access: yes, 2012
Dental pulp contains mesenchymal stem cells (MSCs) similar to those present within bone marrow. Several factors are postulated to contribute to the signalling involved in regulating these cells.
Smith, James George William
core   +7 more sources

Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia

open access: yesLeukemia Research Reports, 2018
Relapse of acute myeloid leukemia (AML) is still dramatically frequent, imposing the need for early markers to quantify such risk. Recent evidence point to a prominent role for extracellular matrix (ECM) in AML, but its prognostic value has not yet been ...
Valerio Izzi   +6 more
doaj   +1 more source

Fragment-based virtual screening identifies a first-in-class preclinical drug candidate for Huntington’s disease

open access: yesScientific Reports, 2022
Currently, there are no therapies available to modify the disease progression of Huntington’s disease (HD). Recent clinical trial failures of antisense oligonucleotide candidates in HD have demonstrated the need for new therapeutic approaches.
Simon Marius Galyan   +5 more
doaj   +1 more source

Buttressing staples with cholecyst-derived extracellular matrix (CEM) reinforces staple lines in an ex vivo peristaltic inflation model [PDF]

open access: yes, 2008
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ Springer Science + Business Media, LLC 2008Background - Staple line leakage and bleeding are the most common problems associated with the ...
Burugapalli, K   +7 more
core   +1 more source

Extracellular Matrix and Atherosclerosis

open access: yesJournal of UOEH, 2010
Many kinds of extracellular matrixes (ECMs) are mainly produced by smooth muscle cells (SMC) in both normal arterial walls and atherosclerotic lesions. In particular, type I, III, IV, V, and VIII collagens and elastin are highly expressed in atherosclerotic lesions.
Ke-Yong, Wang   +2 more
openaire   +3 more sources

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