Results 31 to 40 of about 848,932 (314)
Scientific Reports, 2022 Currently, there are no therapies available to modify the disease progression of Huntington’s disease (HD). Recent clinical trial failures of antisense oligonucleotide candidates in HD have demonstrated the need for new therapeutic approaches.
Simon Marius Galyan +5 more
doaj +1 more source
Cardiac extracellular matrix: a dynamic entity
, 2005 Understanding the regulation of the extracellular matrix of the heart is essential to understanding the chronic changes in heart function in disease states such as hypertension, heart failure, and diabetes.
Brown, Lindsay, Brown, L
core +1 more source
Lipid: Extracellular Matrix Interactions as Therapeutic Targets in the Atherosclerosis of Diabetes
, 2023 Atherosclerosis involves accumulation of lipoproteins to extracellular matrix, in particular proteoglycans, in the arterial wall. The accelerated atherosclerosis in diabetes is contributed to by alternations in both lipoproteins and in the extracellular ...
Kamato, Danielle, Little, Peter
core +1 more source
Translational OncologyMounting evidence suggests that the tissue inhibitor of metalloproteinases-2 (TIMP2) can reduce tumor burden and metastasis. However, the demonstration of such anti-tumor activity and associated mechanisms using in vivo tumor models is lacking.
David Peeney +11 more
doaj +1 more source
Extracellular Matrix Proteases - Cytokine Regulation Role in Cancer and Pregnancy
, 2010 The extracellular matrix proteases act in diverse physiological and pathological processes involving tumor growth, angiogenesis, and pregnancy through the cleavage of extracellular matrix (ECM) and non-matrix proteinaceous substrates.
許博欽;張文君;王鵬惠;林世明;黃思誠 +1 more
core +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 The absence or damage of a tissue is the main cause of most acute or chronic diseases and are one of the appealing challenges that novel therapeutic alternatives have, in order to recover lost functions through tissue regeneration.
Víctor Alfonso Solarte David +6 more
doaj +1 more source
Extracellular-Matrix-Anchored Click Motifs for Specific Tissue Targeting
, 2019 Local presentation of cancer drugs by injectable drug-eluting depots reduces systemic side effects and improves efficacy. However, local depots deplete their drug stores and are difficult to introduce into stiff tissues, or organs, such as the brain ...
Mary R. Adams (8191185) +3 more
core +1 more source
Extracellular matrix remodeling in chronic liver disease [PDF]
, 2021 This review aims to summarize the current knowledge of the extracellular matrix remodeling during hepatic fibrosis. We discuss the diverse interactions of the extracellular matrix with hepatic cells and the surrounding matrix in liver fibrosis, with the ...
Klein, Sabine +7 more
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Brain extracellular matrix [PDF]
Glycobiology, 1996 The extracellular matrix of the adult brain tissue has a unique composition. The striking feature of this matrix is the prominence of lecticans, proteoglycans that contain a lectin domain and a hyaluronic acid-binding domain. Hyaluronic acid and tenascin family adhesive/anti-adhesive proteins are also abundant.
openaire +2 more sources