Results 21 to 30 of about 2,626,097 (306)

The Evolution of Extracellular Matrix [PDF]

Molecular Biology of the Cell, 2010
We present a perspective on the molecular evolution of the extracellular matrix (ECM) in metazoa that draws on research publications and data from sequenced genomes and expressed sequence tag libraries. ECM components do not function in isolation, and the biological ECM system or “adhesome” also depends on posttranslational processing enzymes, cell ...
Özbek, S, Balasubramanian, PG, Chiquet-Ehrismann, R, Tucker, RP, Adams, JC   +4 more
openaire   +5 more sources

Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality

Life Science Alliance, 2018
Mouse embryos with an ablated ability of integrins to bind laminins are still able to form basement membranes, but die just after implantation because of deficient extraembryonic development.
Daiji Kiyozumi, Yukimasa Taniguchi, Itsuko Nakano, Junko Toga, Emiko Yagi, Hidetoshi Hasuwa, Masahito Ikawa, Kiyotoshi Sekiguchi   +7 more
doaj   +1 more source

A chronic moderate methionine administration induced hyperhomocysteinemia associated with cardiovascular disease phenotype in the sand rat Psammomys obesus

Folia Histochemica et Cytobiologica, 2022
INTRODUCTION: Cardiovascular diseases were defined as coronary artery, cerebrovascular, or peripheral arterial disease. Hyperhomocysteinemia (Hhcy) is an independent risk factor of cardiovascular diseases, including atherosclerosis.
Fouzia Zerrouk, Billel Chaouad, Adel Ghoul, Naima Chalour, Anissa Moulahoum, Zineb Khiari, Mohamed el Hadi Cherifi, Souhila Aouichat, Karim Houali, Yasmina Benazzoug   +9 more
doaj   +1 more source

Whole organism profiling of the Timp gene family

Matrix Biology Plus, 2023
Tissue inhibitor of metalloproteinases (TIMPs/Timps) are an endogenous family of widely expressed matrisome-associated proteins that were initially identified as inhibitors of matrix metalloproteinase activity (Metzincin family proteases).
David Peeney, Yu Fan, Sadeechya Gurung, Carolyn Lazaroff, Shashikala Ratnayake, Andrew Warner, Baktiar Karim, Daoud Meerzaman, William G. Stetler-Stevenson   +8 more
doaj   +1 more source

Longevity interventions temporally scale healthspan in Caenorhabditis elegans

iScience, 2022
Summary: Human centenarians and longevity mutants of model organisms show lower incidence rates of late-life morbidities than the average population.
Cyril Statzer, Peter Reichert, Jürg Dual, Collin Y. Ewald   +3 more
doaj   +1 more source

Development of antigen-specific ELISA for circulating autoantibodies to extracellular matrix protein 1 in lichen sclerosus [PDF]

, 2004
Lichen sclerosus is a common, acquired chronic inflammatory skin disease of unknown etiology, although circulating autoantibodies to the glycoprotein extracellular matrix protein 1 (ECM1) have been detected in most patients’ sera.
Sallie M. Neill, Hughes, GJ, Ien Chan, Andrew P. South, Black, Martin M., Oyama, N, McGrath, John A., McGrath, J A, Kawakami, Y, Fenella Wojnarowska, John A. McGrath, Mepani, K, Balbir S. Bhogal, South, AP, South, A P, Chan, Ien, Kaneko, F, Kawakami, Yoshio, Chan, I, Kirti Mepani, South, Andrew P., Bhogal, BS, Neill, Sallie M., Oyama, Noritaka, Bhogal, B S, Noritaka Oyama, Bhogal, Balbir S., David D’Cruz, Neill, SM, Mepani, Kirti, McGrath, JA, Fumio Kaneko, Kaneko, Fumio, D'Cruz, David, Hughes, G J, D'Cruz, D, Martin M. Black, Graham J. Hughes, Neill, S M, Hughes, Graham J., Yoshio Kawakami, Wojnarowska, F, Black, MM, Black, M M, Wojnarowska, Fenella   +44 more
core   +1 more source

MCAM contributes to the establishment of cell autonomous polarity in myogenic and chondrogenic differentiation

Biology Open, 2017
Cell polarity has a fundamental role in shaping the morphology of cells and growing tissues. Polarity is commonly thought to be established in response to extracellular signals.
Artal Moreno-Fortuny, Laricia Bragg, Giulio Cossu, Urmas Roostalu   +3 more
doaj   +1 more source

Extracellular matrix composition and remodeling in human abdominal aortic aneurysms: a proteomics approach. [PDF]

, 2011
Abdominal aortic aneurysms (AAA) are characterized by pathological remodeling of the aortic extracellular matrix (ECM). However, besides the well-characterized elastolysis and collagenolysis little is known about changes in other ECM proteins.
Mandal, K, Marjan Jahangiri, Didangelos, Athanasios, Didangelos, A, Smith, A, Mandal, Kaushik, Saje, A, Smith, Alberto, Xu, Q, Jahangiri, M, Mayr, Manuel; id_orcid, Mayr, M, Athanasios Didangelos, Alberto Smith, Qingbo Xu, Jahangiri, Marjan, Kaushik Mandal, Angelika Saje, Saje, Angelika, Yin, Xiaoke; id_orcid, Xu, Qingbo, Xiaoke Yin, Manuel Mayr, Yin, X   +23 more
core   +1 more source

Dissecting the phenotypic variability of osteogenesis imperfecta

Disease Models & Mechanisms, 2022
Osteogenesis imperfecta (OI) is a heterogeneous family of collagen type I-related diseases characterized by bone fragility. OI is most commonly caused by single-nucleotide substitutions that replace glycine residues or exon splicing defects in the COL1A1
Nadia Garibaldi, Roberta Besio, Raymond Dalgleish, Simona Villani, Aileen M. Barnes, Joan C. Marini, Antonella Forlino   +6 more
doaj   +1 more source

The extracellular matrix at a glance [PDF]

Journal of Cell Science, 2010
![Figure][1] The extracellular matrix (ECM) is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for ...
Christian, Frantz, Kathleen M, Stewart, Valerie M, Weaver   +2 more
openaire   +2 more sources