Results 21 to 30 of about 848,932 (314)

Dissecting the phenotypic variability of osteogenesis imperfecta

open access: yesDisease Models & Mechanisms, 2022
Osteogenesis imperfecta (OI) is a heterogeneous family of collagen type I-related diseases characterized by bone fragility. OI is most commonly caused by single-nucleotide substitutions that replace glycine residues or exon splicing defects in the COL1A1
Nadia Garibaldi   +6 more
doaj   +1 more source

Extracellular Matrix (ECM) [PDF]

open access: yes, 2012
The region of space at the periphery of cyanobacterial cells is the interface between the environment and intracellular processes. This metaspace may include a structure appressed to the outer wall and membrane, such as an extracellular polysaccharide (EPS), a structural and/or physiological discontinuity in the control of flow metabolites, as well as ...
Helm R.F., Potts M.
openaire   +3 more sources

Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth [PDF]

open access: yes, 1995
Extracellular matrix (ECM) molecules are involved in multiple aspects of cell-to-cell signaling during development and in the adult. In nervous system development, specific recognition processes, e.g., during axonal pathfinding and synaptogenesis involve
Arber, S., P Caroni, S Arber, Caroni, P.
core   +1 more source

Fluid biomarkers of extracellular matrix remodelling across neurological diseases [PDF]

open access: yes, 2021
Neurological diseases constitute a major health and socioeconomic issue. Despite an enormous amount of research going on globally, the prevalence and mortality of neurological disorders are still rising.
Minta, Karolina
core   +1 more source

Enzymatic Digestion of Hyaluronan-Based Brain Extracellular Matrix in vivo Can Induce Seizures in Neonatal Mice

open access: yesFrontiers in Neuroscience, 2019
It is well-known that hyaluronic acid (HA) as a component of brain extracellular matrix (ECM) plays a pivotal role in the nervous system and is involved in synaptic plasticity changes in vascular cognitive impairment and dementia.
Alena Balashova   +15 more
doaj   +1 more source

Buttressing staples with cholecyst-derived extracellular matrix (CEM) reinforces staple lines in an ex vivo peristaltic inflation model [PDF]

open access: yes, 2008
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ Springer Science + Business Media, LLC 2008Background - Staple line leakage and bleeding are the most common problems associated with the ...
Burugapalli, K   +7 more
core   +1 more source

SMAD3 mutation in LDS3 causes bone fragility by impairing the TGF-β pathway and enhancing osteoclastogenesis

open access: yesBone Reports, 2022
Loss-of-function mutations in SMAD3 cause Loeys-Dietz syndrome type 3 (LDS3), a rare autosomal-dominant connective tissue disorder characterized by vascular pathology and skeletal abnormalities.
Ahmed El-Gazzar   +12 more
doaj   +1 more source

Modeling cell movement in anisotropic and heterogeneous network tissues [PDF]

open access: yes, 2007
Cell motion and interaction with the extracellular matrix is studied deriving a kinetic model and considering its diffusive limit. The model takes into account of chemotactic and haptotactic effects, and obtains friction as a result of the interactions ...
A. Chauviere   +6 more
core   +1 more source

Biomechanical assessment of extracellular matrix in native and tissue engineered cartilage across lenght scales [PDF]

open access: yes, 2012
Musculoskeletal diseases (MSD) and related disorders account for the largest fraction of temporary and permanent disabilities, and are often considered to be an inevitable consequence of aging.
Loparic, Marko
core   +1 more source

Extracellular matrix gene expression signatures as cell type and cell state identifiers

open access: yesMatrix Biology Plus, 2021
Transcriptomic signatures based on cellular mRNA expression profiles can be used to categorize cell types and states. Yet whether different functional groups of genes perform better or worse in this process remains largely unexplored.
Fabio Sacher   +3 more
doaj   +1 more source

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