Results 1 to 10 of about 565,976 (302)

Phylobone: a comprehensive database of bone extracellular matrix proteins in human and model organisms [PDF]

Bone Research, 2023
The bone extracellular matrix (ECM) contains minerals deposited on highly crosslinked collagen fibrils and hundreds of non-collagenous proteins. Some of these proteins are key to the regulation of bone formation and regeneration via signaling pathways ...
Margalida Fontcuberta-Rigo, Miho Nakamura, Pere Puigbò   +2 more
doaj   +2 more sources

Development potential of extracellular matrix hydrogels as hemostatic materials

Frontiers in Bioengineering and Biotechnology, 2023
The entry of subcutaneous extracellular matrix proteins into the circulation is a key step in hemostasis initiation after vascular injury. However, in cases of severe trauma, extracellular matrix proteins are unable to cover the wound, making it ...
Dan Cai, Wei Weng
doaj   +1 more source

Decellularized Tissues for Wound Healing: Towards Closing the Gap Between Scaffold Design and Effective Extracellular Matrix Remodeling

Frontiers in Bioengineering and Biotechnology, 2022
The absence or damage of a tissue is the main cause of most acute or chronic diseases and are one of the appealing challenges that novel therapeutic alternatives have, in order to recover lost functions through tissue regeneration.
Víctor Alfonso Solarte David, Víctor Alfonso Solarte David, Viviana Raquel Güiza-Argüello, Martha L. Arango-Rodríguez, Claudia L. Sossa, Claudia L. Sossa, Silvia M. Becerra-Bayona   +6 more
doaj   +1 more source

Extracellular Targets to Reduce Excessive Scarring in Response to Tissue Injury

Biomolecules, 2023
Excessive scar formation is a hallmark of localized and systemic fibrotic disorders. Despite extensive studies to define valid anti-fibrotic targets and develop effective therapeutics, progressive fibrosis remains a significant medical problem ...
Jolanta Fertala, Mark L. Wang, Michael Rivlin, Pedro K. Beredjiklian, Joseph Abboud, William V. Arnold, Andrzej Fertala   +6 more
doaj   +1 more source

Natural biopolymer-based hydrogels as designer matrices for organoid cultures [PDF]

Organoid, 2023
Matrigel, a mouse sarcoma-derived extract, is considered the gold standard for organoid cultures. However, it has several drawbacks, including inconsistent and ill-defined composition, varying quality between batches, and potential cancer-related health ...
Yun Kee Jo
doaj   +1 more source

The functional role of soluble proteins acquired by extracellular vesicles

Journal of Extracellular Biology, 2022
Extracellular vesicles (EVs) are lipid bilayer‐enclosed nanosized particles released by all cell types during physiological as well as pathophysiological processes to carry out diverse biological functions, including acting as sources of cellular dumping,
Ana Paula Ramos, Heitor Gobbi Sebinelli, Pietro Ciancaglini, Nicola Rosato, Saida Mebarek, Rene Buchet, José Luis Millán, Massimo Bottini   +7 more
doaj   +1 more source

Integrins and extracellular matrix proteins modulate adipocyte thermogenic capacity

Scientific Reports, 2021
Obesity and the metabolic disease epidemic has led to an increase in morbidity and mortality. A rise in adipose thermogenic capacity via activation of brown or beige fat is a potential treatment for metabolic diseases.
Maria A. Gonzalez Porras, Katerina Stojkova, Marcella K. Vaicik, Amanda Pelowe, Anna Goddi, Alanis Carmona, Byron Long, Amina A. Qutub, Anjelica Gonzalez, Ronald N. Cohen, Eric M. Brey   +10 more
doaj   +1 more source

Characterization of glomerular extracellular matrix in IgA nephropathy by proteomic analysis of laser-captured microdissected glomeruli

BMC Nephrology, 2019
Background IgA nephropathy (IgAN) involves mesangial matrix expansion, but the proteomic composition of this matrix is unknown. The present study aimed to characterize changes in extracellular matrix in IgAN.
Flavia Teodora Ioana Paunas, Kenneth Finne, Sabine Leh, Tarig Al-Hadi Osman, Hans-Peter Marti, Frode Berven, Bjørn Egil Vikse   +6 more
doaj   +1 more source

Engineered scaffolds based on mesenchymal stem cells/preosteoclasts extracellular matrix promote bone regeneration

Journal of Tissue Engineering, 2020
Recently, extracellular matrix-based tissue-engineered bone is a promising approach to repairing bone defects, and the seed cells are mostly mesenchymal stem cells.
Rui Dong, Yun Bai, Jingjin Dai, Moyuan Deng, Chunrong Zhao, Zhansong Tian, Fanchun Zeng, Wanyuan Liang, Lanyi Liu, Shiwu Dong   +9 more
doaj   +1 more source

The Extracellular Matrix of Staphylococcus aureus Biofilms Comprises Cytoplasmic Proteins That Associate with the Cell Surface in Response to Decreasing pH

mBio, 2014
Biofilm formation by Staphylococcus aureus involves the formation of an extracellular matrix, but the composition of this matrix has been uncertain. Here we report that the matrix is largely composed of cytoplasmic proteins that reversibly associate with
Lucy Foulston, Alexander K. W. Elsholz, Alicia S. DeFrancesco, Richard Losick   +3 more
doaj   +1 more source