Identification of a novel zinc metalloprotease through a global analysis of clostridium difficile extracellular proteins [PDF]
Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial pathogenesis, biological functions of only a few are known.
Maria Scarselli (247406) +39 more
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Extracellular matrix composition and remodeling in human abdominal aortic aneurysms: a proteomics approach. [PDF]
Abdominal aortic aneurysms (AAA) are characterized by pathological remodeling of the aortic extracellular matrix (ECM). However, besides the well-characterized elastolysis and collagenolysis little is known about changes in other ECM proteins.
Mandal, K +23 more
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Biofilm formation by Staphylococcus aureus involves the formation of an extracellular matrix, but the composition of this matrix has been uncertain. Here we report that the matrix is largely composed of cytoplasmic proteins that reversibly associate with
Lucy Foulston +3 more
doaj +1 more source
A view of the genetic and proteomic profile of extracellular matrix molecules in aging and stroke
IntroductionModification of the extracellular matrix (ECM) is one of the major processes in the pathology of brain damage following an ischemic stroke.
Martina Chmelova +10 more
doaj +1 more source
Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement [PDF]
The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the bloodstream, then invades and colonizes a variety of host tissues.
Matthew L Rotondi +54 more
core +1 more source
Stepwise Evolution of Coral Biomineralization Revealed with Genome-Wide Proteomics and Transcriptomics. [PDF]
Despite the importance of stony corals in many research fields related to global issues, such as marine ecology, climate change, paleoclimatogy, and metazoan evolution, very little is known about the evolutionary origin of coral skeleton formation.
Takeshi Takeuchi +4 more
doaj +1 more source
Insulin-like growth factor binding proteins initiate cell death and extracellular matrix remodeling in the mammary gland [PDF]
We have demonstrated that insulin-like growth factor binding protein-5 (IGFBP-5) production by mammary epithelial cells increases dramatically during forced involution of the mammary gland in rats, mice and pigs.
Beattie, J +19 more
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Analysis of the proteinaceous components of the organic matrix of calcitic sclerites from the soft coral Sinularia sp. [PDF]
An organic matrix consisting of a protein-polysaccharide complex is generally accepted as an important medium for the calcification process. While the role this "calcified organic matrix" plays in the calcification process has long been appreciated, the ...
Ryuichi Shinjo (187750) +11 more
core +2 more sources
Tenascin-C fragments are endogenous inducers of cartilage matrix degradation [PDF]
Cartilage destruction is a hallmark of osteoarthritis (OA) and is characterized by increased protease activity resulting in the degradation of critical extracellular matrix (ECM) proteins essential for maintaining cartilage integrity.
Hermansson, M +12 more
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Potentially virulence-related extracellular proteins of Streptococcus equi [PDF]
Equine strangles, a disease of the upper respiratory tract caused by the bacterium Streptococcus equi subspecies equi, is one of the most commonly diagnosed and serious diseases in horses. However, the molecular basis of S. equi subsp.
Lannergård, Jonas
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