Results 31 to 40 of about 3,243,882 (355)
Extracellular Matrix Remodeling in Chronic Liver Disease
Current Tissue Microenvironment Reports, 2021 This review aims to summarize the current knowledge of the extracellular matrix remodeling during hepatic fibrosis. We discuss the diverse interactions of the extracellular matrix with hepatic cells and the surrounding matrix in liver fibrosis, with the ...
C. Ortiz +5 more
semanticscholar +1 more source
Dissecting the phenotypic variability of osteogenesis imperfecta
Disease Models & Mechanisms, 2022 Osteogenesis imperfecta (OI) is a heterogeneous family of collagen type I-related diseases characterized by bone fragility. OI is most commonly caused by single-nucleotide substitutions that replace glycine residues or exon splicing defects in the COL1A1
Nadia Garibaldi +6 more
doaj +1 more source
The Bone Extracellular Matrix in Bone Formation and Regeneration
Frontiers in Pharmacology, 2020 Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio-environment with precisely regulated mechanical and biochemical properties.
Xiao Lin +3 more
semanticscholar +1 more source
Frontiers in Neuroscience, 2019 It is well-known that hyaluronic acid (HA) as a component of brain extracellular matrix (ECM) plays a pivotal role in the nervous system and is involved in synaptic plasticity changes in vascular cognitive impairment and dementia.
Alena Balashova +15 more
doaj +1 more source
Bone Reports, 2022 Loss-of-function mutations in SMAD3 cause Loeys-Dietz syndrome type 3 (LDS3), a rare autosomal-dominant connective tissue disorder characterized by vascular pathology and skeletal abnormalities.
Ahmed El-Gazzar +12 more
doaj +1 more source
Extracellular matrix gene expression signatures as cell type and cell state identifiers
Matrix Biology Plus, 2021 Transcriptomic signatures based on cellular mRNA expression profiles can be used to categorize cell types and states. Yet whether different functional groups of genes perform better or worse in this process remains largely unexplored.
Fabio Sacher +3 more
doaj +1 more source
Scientific Reports, 2022 Currently, there are no therapies available to modify the disease progression of Huntington’s disease (HD). Recent clinical trial failures of antisense oligonucleotide candidates in HD have demonstrated the need for new therapeutic approaches.
Simon Marius Galyan +5 more
doaj +1 more source
Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation
Frontiers in Immunology, 2020 The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 (TSG-6), and inter alpha trypsin inhibitor (IαI) during inflammation in a number ...
T. Wight +7 more
semanticscholar +1 more source
Extracellular Matrix (ECM) [PDF]
, 2012 The region of space at the periphery of cyanobacterial cells is the interface between the environment and intracellular processes. This metaspace may include a structure appressed to the outer wall and membrane, such as an extracellular polysaccharide (EPS), a structural and/or physiological discontinuity in the control of flow metabolites, as well as ...
Helm R.F., Potts M.
openaire +3 more sources
Leukemia Research Reports, 2018 Relapse of acute myeloid leukemia (AML) is still dramatically frequent, imposing the need for early markers to quantify such risk. Recent evidence point to a prominent role for extracellular matrix (ECM) in AML, but its prognostic value has not yet been ...
Valerio Izzi +6 more
doaj +1 more source