Results 61 to 70 of about 1,191,619 (293)

Smad4 regulates growth plate matrix production and chondrocyte polarity. [PDF]

, 2017
Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Alliston, Tamara, Berthet, Ellora, Cantu, Andrea, Laird, Diana J, Whitaker, Amanda T   +4 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Extracellular regulation of metalloproteinases [PDF]

, 2015
Matrix metalloproteinases (MMPs) and adamalysin-like metalloproteinase with thrombospondin motifs (ADAMTSs) belong to the metzincin superfamily of metalloproteinases and they play key roles in extracellular matrix catabolism, activation and inactivation ...
Bannikov, Barcelona, Barmina, Barrett, Brew, Butler, Crabbe, Crabbe, Dumin, Elkins, Ellerbroek, Emonard, Emonard, Emonard, Etique, Fanjul-Fernández, Fosang, Fu, Fushimi, Galvez, Gendron, George, Geurts, Gillian Murphy, Gorovoy, Grimsley, Gu, Guo, Gálvez, Hahn-Dantona, Herz, Herz, Higashi, Iida, Kashiwagi, Kazuhiro Yamamoto, Kolkenbrock, Kowal, Kuno, Lafleur, Lillis, Linda Troeberg, Liu, Lu, Mantuano, Messaritou, Morgunova, Mu, Nagase, Nagase, Noguchi, Omura, Page-McCaw, Piccard, Quinn, Ra, Remacle, Rozanov, Sakamoto, Scilabra, Selvais, Shiomi, Sohail, Stricker, Strickland, Sudbeck, Takino, Thevenard, Troeberg, Troeberg, Uekita, Van den Steen, Van Wart, Visse, von Arnim, Walling, Wang, Weiss, Willingham, Winberg, Yamamoto, Yamamoto, Yamamoto, Yamamoto, Yang, Yu, Yáñez-Mó   +86 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plasma and Aorta Biochemistry and MMPs Activities in Female Rabbit Fed Methionine Enriched Diet and Their Offspring

Journal of Nutrition and Metabolism, 2017
This study investigated whether a high Met diet influences biochemical parameters, MMPs activities in plasma, and biochemical and histological remodeling in aorta, in both pregnant female rabbits and their offspring.
Khira Othmani Mecif, Souhila Aouichat Bouguerra, Yasmina Benazzoug   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine

Scientific Reports
Biological aging clocks capture heterogeneous rates of aging in individuals and transform current medical practice toward translational preventive medicine. Here, we developed a clinical aging clock based on routine blood biochemistry markers from 59,741
David H. Meyer, Gabriel Mejia, Adrian Molière, Panupong Wangprapa, Tanawat Khunlertkit, Polakit Teekakirikul, Collin Y. Ewald, Claudio Viecelli   +7 more
doaj   +1 more source

Synthesis of extracellular matrix components by human ciliary muscle cells in culture [PDF]

, 1992
The production and spatial organization of connective tissue components in ciliary muscle cell cultures was studied with immunohistochemical and ultrastructural methods.
Baur, A., Lütjen-Drecoll, E., Tamm, Ernst R.   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

STAT3 and SOCS3 expression patterns during murine placenta development

European Journal of Histochemistry, 2013
Signal transducers and activators of transcription 3 (Stat3) has been identified as an important signal transducer in the invasive phenotype of the trophoblasts cells in in vitro studies.
S. San Martin, J. Fitzgerald, M. Weber, M. Párraga, T. Sáez, T.M. Zorn, U.R. Markert   +6 more
doaj   +1 more source