Results 81 to 90 of about 2,626,097 (306)

A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine

Scientific Reports
Biological aging clocks capture heterogeneous rates of aging in individuals and transform current medical practice toward translational preventive medicine. Here, we developed a clinical aging clock based on routine blood biochemistry markers from 59,741
David H. Meyer, Gabriel Mejia, Adrian Molière, Panupong Wangprapa, Tanawat Khunlertkit, Polakit Teekakirikul, Collin Y. Ewald, Claudio Viecelli   +7 more
doaj   +1 more source

Plasma and Aorta Biochemistry and MMPs Activities in Female Rabbit Fed Methionine Enriched Diet and Their Offspring

Journal of Nutrition and Metabolism, 2017
This study investigated whether a high Met diet influences biochemical parameters, MMPs activities in plasma, and biochemical and histological remodeling in aorta, in both pregnant female rabbits and their offspring.
Khira Othmani Mecif, Souhila Aouichat Bouguerra, Yasmina Benazzoug   +2 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Silicon and the Plant Extracellular Matrix [PDF]

Frontiers in Plant Science, 2016
Silicon (Si) is one of the most abundant elements on earth. Although not considered essential for the growth and development of higher plants, it is nonetheless known to increase vigor and to play protective roles. Its protective effects include for instance alleviation of (a)biotic stress damages and heavy metal toxicity. Si was shown to interact with
Guerriero, Gea, Hausman, Jean-Francois, Legay, Sylvain   +2 more
openaire   +3 more sources

Insulin-like growth factor binding proteins initiate cell death and extracellular matrix remodeling in the mammary gland [PDF]

, 2005
We have demonstrated that insulin-like growth factor binding protein-5 (IGFBP-5) production by mammary epithelial cells increases dramatically during forced involution of the mammary gland in rats, mice and pigs.
Beattie, J, Whitelaw C. B. A., ACCORSI, PIER ATTILIO, Hurley, W, Boutinaud, M, Kolb A., Allan G. A., Tonner, E, Wilde, C J, Boutinaud M., Wilde C. J., Beattie J., Accorsi, P A, Flint, D J, Flint D. J., Tonner E., Whitelaw, C B A, Hurley W., Kolb, A F, Allan, G J   +19 more
core   +1 more source

Effect of Roxadustat on Cardiometabolism in Healthy Individuals (ROXACardioMeta): Protocol for a Double-Blind, Placebo-Controlled and Randomised Cross-Over Trial

Methods and Protocols
Hypoxia activates hypoxia-inducible factors (HIFs), which regulate genes involved in erythropoiesis, angiogenesis, and metabolism. HIF stability is controlled by oxygen-dependent HIF prolyl 4-hydroxylases (HIF-P4Hs).
Emma Klemola, Joona Tapio, Rasmus I. P. Valtonen, Mikko P. Tulppo, Janne Hukkanen, Peppi Koivunen   +5 more
doaj   +1 more source

Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix. [PDF]

PLoS ONE, 2017
Extracellular matrix plays a role in differentiation and phenotype development of its resident cells. Although cardiac extracellular matrix from the contractile tissues has been studied and utilized in tissue engineering, extracellular matrix properties ...
Jessica M Gluck, Anthony W Herren, Sergey Yechikov, Hillary K J Kao, Ambereen Khan, Brett S Phinney, Nipavan Chiamvimonvat, James W Chan, Deborah K Lieu   +8 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Extracellular Vesicles as Matrix Messengers

The extracellular matrix (ECM) is a dynamic, acellular framework that maintains homeostasis and supports the preservation of tissues’ structural integrity.
Poppa, Giuseppina, Giusti, Ilaria, Dolo, Vincenza   +2 more
core   +1 more source

The extracellular matrix regulates MaeuCath1a gene expression

, 2013
We have previously shown that the gene for MaeuCath1, a cathelicidin secreted in wallaby milk is alternately spliced into two variants, MaeuCath1a and MaeuCath1b which are temporally regulated in order to provide antimicrobial protection to the newborn ...
Lefevre, Christophe, Wanyonyi, Stephen S., Sharp, Julie A., Nicholas, Kevin R.   +3 more
core   +1 more source