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2021Aberrant deposition of the extracellular matrix (ECM) causes fibrosis and leads to ECM stiffening. This fibrotic ECM provides biological and biophysical stimulations to alter cell activity and drive progression of fibrosis. As an emerging discipline, mechanobiology aims to access the impact of both these cues on cell behavior and relates the ...
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2023The purpose of this article is to summarize current and historical literature demonstrating the role of the Extracellular Matrix (ECM) in the various stages of the wound healing cascade. ECM is a three-dimensional framework that is found in all human tissues.
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The Role of Mechanical Stimulation in Engineering of Extracellular Matrix (ECM)
2006 International Conference of the IEEE Engineering in Medicine and Biology Society, 2006The engineering of ECM in vitro is a critical area of research in tissue engineering. Cells respond to mechanical stimuli and regulate the metabolic functions via mechanotransduction and synthesise ECM. This paper reviews key pathways. In vitro studies of mechanotransduction on macroscopic tissues in specialised automated bioreactors that are capable ...
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