Results 221 to 230 of about 169,199 (298)

Albumin Restores Endothelial Cell Mitochondrial Morphology in Patients With Decompensated Cirrhosis. [PDF]

Liver Int
Fischer SE, Postma RJ, Bijkerk R, Kerbert AJC, van Zonneveld AJ, Coenraad MJ.   +5 more
europepmc   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

GPT2-mediated Glutamate to α-Ketoglutaric Acid Conversion in Cardiac Fibroblast Promotes Fibrosis. [PDF]

JACC Basic Transl Sci
Chen Y, Liao F, Wang J, Zhao J, Xu Y, Chen Q, Hong T, Lv K, Li Q, Chen X, Xiao C, Wang L, Li G, Ke C, Cai J, Li J, Sheng S, Wang J, Wu X, Ruan Y, Zhang F, Wu R, Xu Y, Zhu W, Xu Y, Wang J, Ni C, Hu X.   +27 more
europepmc   +1 more source

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Mechanisms of Mechanical Stress-Induced Vascular Remodeling via the Lactate-PKM2 Axis and Implications for Microgravity Adaptation. [PDF]

Int J Mol Sci
Li N, Liu L, Wang D, Wang J, Tie Y, Li X, Li J, Gao Y, Yang C, Wang Y.   +9 more
europepmc   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Targeting mitochondrial deubiquitinase USP30 to induce mitophagy in heteroplasmic mitochondrial diseases. [PDF]

Pharmacol Rep
Pinho BR, Martins V, Chacko AR, Nogueira C, Duchen MR, Oliveira JMA.   +5 more
europepmc   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Immunoregulatory effect of metformin in monocytes exposed to SARS-CoV-2 spike protein subunit 1. [PDF]

Immunometabolism (Cobham)
Maurmann RM, Davis K, Mosalmanzadeh N, Landvoigt Schmitt B, Pence D.   +4 more
europepmc   +1 more source

Chemistry of bacteriochlorophyll b [PDF]

, 1983
Cmiel, Edmund, Scheer, Hugo, Schneider, Siegfried, Steiner, R.   +3 more
core