Results 221 to 230 of about 659,606 (256)

Benzothiazepane-Based Curcumin Analogs Show Selective Effects on Respiration, Permeability, and Growth of Gut-Liver (Co-Culture) Cell Models. [PDF]

Chem Biol Drug Des
Li F, De Munck J, Morlion F, Magdalenic K, Rajkovic A, D'hooghe M, Van Camp J, Grootaert C.   +7 more
europepmc   +1 more source

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

Hierarchical Nanoplatform Integrating Oxidative–Acidic Microenvironment Remodeling and Bone Homeostasis Modulation for Diabetic Bone Defect Therapy

Advanced Science, EarlyView.
A hierarchical CM/LDH nanoplatform integrates ROS‐scavenging Ce‐MOF nanozymes with acid‐neutralizing CaAl‐LDH and is delivered within GelMA hydrogel to diabetic bone defects. By remodeling the oxidative‐acidic microenvironment, preserving mitochondrial homeostasis, and suppressing mtDNA–cGAS–STING inflammatory signaling, CM/LDH reduces proinflammatory ...
Xu Chen, Xingyu Zhu, Zhixin Qiu, Yijia Zhu, Xinhui Zheng, Dongqi Fan, Jinglei Zhan, Congxiu Mao, Ping Ji, Tao Chen, Qingqing He   +10 more
wiley   +1 more source

Aged Mitochondrial DNA Is Associated With Aberrant Acute Exercise-Induced Redox Responses in Human Skeletal Muscle. [PDF]

Aging Cell
Ruple BA, Carlini NA, Kofoed JS, Rostamkhani H, Hanson BE, Craig JC, Osburn SC, Manuel AM, Stewart PA, Wanagat J, Broxterman RM, Trinity JD.   +11 more
europepmc   +1 more source

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Metformin Inhibits Cardiac Fibroblast Differentiation by Promoting Fatty Acid β-Oxidation: Implications for Age-Associated Cardiac Fibrosis. [PDF]

Cells
Chempon H, Kumari S, Bonam SR, Kotamraju S.   +3 more
europepmc   +1 more source

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

Advanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li, Yu Zhang, Yu Chen, Lingyun He, Xian Shen, Weijian Sun, Hongbo Zhang   +6 more
wiley   +1 more source

Metabolic impairments in peripheral blood mononuclear cells after BNT162b2 vaccination in liver transplantation adolescents. [PDF]

Sci Rep
Buranapraditkun S, Kitkumthorn N, Chaiwongkot A, Thantiworasit P, Sintusek P.   +4 more
europepmc   +1 more source

Human CD4⁺ iNKT cells have highly oxidative metabolism and use glycogen reserves to sustain IFN-γ production in nutrient-limited environments. [PDF]

Front Immunol
Patankar NM, Smith KA, Jacobsen N, Bharadwaj NS, Gumperz JE.   +4 more
europepmc   +1 more source