Results 241 to 250 of about 169,199 (298)

Bioenergetic and metabolic aberrations in induced pluripotent stem cell-derived cardiomyocytes generated from a patient with Wolff-Parkinson-White syndrome caused a <i>PRKAG2</i> mutation. [PDF]

Front Cardiovasc Med
Baskin P, Abramovich I, Milman H, Ben Jehuda R, Agranovich B, Davidor M, Buffard V, Herron T, Ahmad F, Arad M, Ricke-Hoch M, Binah O.   +11 more
europepmc   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Extracellular ATP Functions as a Metabolic Lineage Selection Signal That Stabilizes Tc9 Cells During Adoptive T Cell Therapy. [PDF]

Int J Mol Sci
Ren J, Gong Z, Zhong Y, Xiao R, Urooj K, Gao Y, Bi E, Wang H.   +7 more
europepmc   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Pioglitazone Modulates p65-Mediated Mitochondrial Bioenergetics: Implications for Acetaldehyde-Induced HIV Replication in Alveolar Macrophages. [PDF]

Biomolecules
New-Aaron M, Chang S, Fan X, Mehta A, Auld SC, Staitieh BS, Koval M, Yeligar SM.   +7 more
europepmc   +1 more source

Bio‐Inspired Mechanical Amplification Block on Implantable Tactile Sensors

Advanced Electronic Materials, EarlyView.
 . ABSTRACT Implantable strain sensors offer opportunities for continuous biomechanical monitoring, but their performance deteriorates severely once embedded in soft tissue due to mechanical shielding that suppresses strain transmission to the sensing layer.
Sungbin Choi, Yeong‐sinn Ye, Chanho Jeong, Yujin Mun, Suyoun Oh, Tae‐il Kim   +5 more
wiley   +1 more source

Sex-dependent differences in bioenergetics of young mouse brain microvasculature: implications for oxygen-glucose deprivation and reoxygenation injury. [PDF]

Am J Physiol Heart Circ Physiol
Sure VN, Oruganti L, Sakamuri SSVP, Pasupulati SC, Ageeli RY, Chandra P, Rutkai I, Wang X, Lindsey SH, Mostany R, Busija DW, Katakam PVG.   +11 more
europepmc   +1 more source

Advancing Fruit Bioimpedance Monitoring With Sustainable, Soft, And Bio‐Based Electrodes Beyond ECG

Advanced Electronic Materials, EarlyView.
Electrical impedance spectroscopy enables non‐destructive fruit quality monitoring, but conventional ECG and needle electrodes compromise signal stability, fruit physiology, and sustainability. This perspective highlights the transition toward soft, biocompatible, and biodegradable electrode interfaces based on natural substrates, bio‐derived ...
Sundus Riaz, Ahmed Rasheed, Angelo Zanella, Almudena Rivadeneyra, Paolo Lugli, Luisa Petti, Pietro Ibba   +6 more
wiley   +1 more source

Investigating neural impairments in psychotic disorders using electroencephalography and cortical spheroids. [PDF]

Transl Psychiatry
Reis de Assis D, Pentz AB, Requena Osete J, Ievglevskyi O, Vandenberghe M, Akkouh IA, Mäki-Marttunen T, Jönsson EG, Andreassen OA, Djurovic S, Kondratskaya E, Elvsåshagen T.   +11 more
europepmc   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source