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The Extracellular Space of the Brain
1965Publisher Summary This chapter discusses the extracellular space of the brain. Some 10–15 % of the volume of the brain behaves as though it were extracellular, in the sense that under appropriate conditions an extracellular “tag,” such as sucrose, will come into equilibrium with it. The appropriate condition is that the sucrose should be presented by
H. Davson, M. Bradbury
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Extracellular space determination in gallbladder mucosa
Biochimica et Biophysica Acta (BBA) - General Subjects, 1975Abstract Sucrose seems to be the best marker of the extracellular space in gallbladder mucosa. Inulin space is always smaller than sucrose space and the difference seems to be due to a sweeping-away effect in the intercellular channels as metabolic inhibitors and ouabain reduce it. Mannitol space continuously increases and this substance is likely to
D, Cremaschi, S, Hénin
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The extracellular space of rat intestine ?in vivo?
Pfl�gers Archiv European Journal of Physiology, 1972The extracellular space (ECS) of rat jejunum, ileum and colon were determined in “in vivo” condition both by means of a continuous perfusion technique and after ligature of the renal pedicles. As a marker, intravenously injected14C-polyethylenglycol (14C-PEG) was used.
G, Esposito, A, Faelli, V, Capraro
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Regional Variation of Extracellular Space in the Hippocampus
Science, 1990The factors responsible for the unusual susceptibility of the hippocampus to seizures and ischemic cell damage are not well understood. The CA1 pyramidal subfield of the hippocampus is particularly vulnerable to seizure activity and damage after ischemia.
C J, McBain +2 more
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EXTRACELLULAR SPACE IN THE CENTRAL NERVOUS SYSTEM
Archives of Neurology And Psychiatry, 1955A KNOWLEDGE of the volume and composition of the extracellular space in brain substance is of considerable importance in any investigation dealing with electrolyte concentrations in nerve tissue and with mechanisms of fluid shifts in cerebral edema. Although fluid partitions have been thoroughly studied in the body as a whole, and in muscle tissue in ...
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2001 interactions? An extracellular space odyssey
Current Opinion in Neurobiology, 1991Abstract Recent investigation has revealed an incredible degree of complexity in the types and functions of extracellular matrix molecules and their cellular receptors in the nervous system.
K J, Tomaselli, K M, Neugebauer
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THE EXTRACELLULAR SPACE IN EXPERIMENTAL BRAIN TUMORS
Acta Neurologica Scandinavica, 1971Experimental brain tumors were produced in mice with 20–methyl cholanthrene, and the uptake of radioactive extracellular markers was studied by tissue assay and autoradiography. The tracers included C14-sucrose, C14-inulin, and H3inulin. The water content and isotope concentration of both gliomas and meningiomas were higher than those of normal brain ...
T, Kobayashi, L, Bakay
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Distribution of the extracellular space of the amphibian lens
Experimental Eye Research, 1976Abstract The extracellular space of the amphibian lens, measured with [14C]inulin, was equivalent to 7% of the tissue water. In decapsulated lenses it was only 1·2% so that about 80% of the total extracellular space is located peripherally. The total [14C]mannitol space was larger (12%) though the capsular part was the same as that found using inulin.
T, Yorio, P J, Bentley
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Plasticity of Extracellular Space
2002The extracellular space (ECS) of the nervous tissue is a microenvironment for nerve cells, and an important communication channel (1–4). It includes ions, transmitters, metabolites, peptides, neurohormones, other neuroactive substances, and molecules of the extracellular matrix (ECM), and directly or indirectly affects neuronal and glial cell functions.
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The determination of extracellular space using hemoglobin
Experientia, 1978The ECS of guinea-pig atria and frog sartorii can be determined using hemoglobin. For guinea-pig atria an ECS of (32.2 +/- 2.6)% wet wt for frog sartorii an ECS of (12.4 +/- 1.0)% wet wt can be measured.
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