Results 21 to 30 of about 4,618,222 (282)
Wakefulness affects synaptic and network activity by increasing extracellular astrocyte-derived adenosine [PDF]
, 2012 Loss of sleep causes an increase in sleep drive and deficits in hippocampal-dependent memory. Both of these responses are thought to require activation of adenosine A1 receptors (adorA1Rs) and release of transmitter molecules including ATP, which is ...
Schmitt, L. Ian +9 more
core +1 more source
The Lysosomal Sequestration of Tyrosine Kinase Inhibitors and Drug Resistance
Biomolecules, 2019 The Lysosomal sequestration of weak-base anticancer drugs is one putative mechanism for resistance to chemotherapy but it has never been directly proven. We addressed the question of whether the lysosomal sequestration of tyrosine kinase inhibitors (TKIs)
Eliska Ruzickova +4 more
doaj +1 more source
Understanding and Applying Extracellular Recordings in Awake, Behaving Animals [PDF]
, 2012 Section I of this thesis presents specific projects applying extracellular recordings in macaques. The results demonstrate a novel relative position code employed by individual neurons in the dorsal premotor cortex during reaches and saccades, which may ...
Nelson, Matthew John
core +1 more source
Thimet Oligopeptidase—A Classical Enzyme with New Function and New Form
Immuno, 2021 Peptidases generate bioactive peptides that can regulate cell signaling and mediate intercellular communication. While the processing of peptide precursors is initiated intracellularly, some modifications by peptidases may be conducted extracellularly ...
Yu Liu +3 more
doaj +1 more source
Viruses on the Move in the Extracellular Space [PDF]
Plant Physiology, 2019 Positive-strand (+) RNA viruses act as their own messengers, encoding an RNA-dependent RNA polymerase that can replicate their sense RNA genome. This allows (+) RNA viruses to replicate outside the nucleus, within replication complexes formed from host organelle membranes often called ...
openaire +2 more sources
Formation of Extracellular Traps - the Effective Mechanism of Organism Protection from Pathogen
Проблемы особо опасных инфекций, 2012 Summarized and analyzed are modern literature data on capability of cells (neutrophils, eosinophils and labrocytes) realizing the mechanisms of innate immunity, to form extracellular traps that capture and kill pathogens by secretion of DNA and ...
A. L. Kravtsov
doaj +1 more source
Promotion of Lung Cancer Metastasis by SIRT2‐Mediated Extracellular Protein Deacetylation
Advanced Science, 2023 Acetylation of extracellular proteins has been observed in many independent studies where particular attention has been given to the dynamic change of the microenvironmental protein post‐translational modifications.
Meng Wu +24 more
doaj +1 more source
Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes [PDF]
, 2013 Introduction: In recent years, there has been an exponential increase in the number of studies aiming to understand the biology of exosomes, as well as other extracellular vesicles.
Szabó, Tamas G +21 more
core +1 more source
Zaporožskij Medicinskij Žurnal, 2017 Objective. To study the response of volume and osmoregulatory kidney function to increased volume of extracellular space (IVECS) with dopamine-dependent compensation of sepsis-induced hypotension. Materials and methods. The inclusion criteria involved
V. M. Konovchuk, A. V. Andrushchak
doaj +1 more source
eLife, 2017 Transport of solutes through brain involves diffusion and convection. The importance of convective flow in the subarachnoid and paravascular spaces has long been recognized; a recently proposed ‘glymphatic’ clearance mechanism additionally suggests that ...
Alex J Smith +4 more
doaj +1 more source