Results 41 to 50 of about 596,635 (290)

Tumor interstitial fluid formation, characterization and clinical implications

open access: yesFrontiers in Oncology, 2015
The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase, together constituting the tissue microenvironment.
Marek eWagner, Helge eWiig
doaj   +1 more source

Simulation of cell movement through evolving environment: a fictitious domain approach [PDF]

open access: yes, 2012
A numerical method for simulating the movement of unicellular organisms which respond to chemical signals is presented. Cells are modelled as objects of finite size while the extracellular space is described by reaction-diffusion partial differential ...
Burrage, K.   +3 more
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Studying the extracellular contribution to the double wave vector diffusion-weighted signal

open access: yesCurrent Directions in Biomedical Engineering, 2015
The use of two independent diffusion periods between excitation and acquisition, known as double wave vector (DWV) diffusion-weighting or double diffusion encoding, was proven to yield structural information that it is otherwise not easily available in ...
Ulloa Patricia   +2 more
doaj   +1 more source

Cysteine Cathepsins and Their Extracellular Roles: Shaping the Microenvironment

open access: yesCells, 2019
For a long time, cysteine cathepsins were considered primarily as proteases crucial for nonspecific bulk proteolysis in the endolysosomal system. However, this view has dramatically changed, and cathepsins are now considered key players in many important
Eva Vidak   +3 more
doaj   +1 more source

Morphogen Transport in Epithelia

open access: yes, 2006
We present a general theoretical framework to discuss mechanisms of morphogen transport and gradient formation in a cell layer. Trafficking events on the cellular scale lead to transport on larger scales. We discuss in particular the case of transcytosis
B. Houchmandzadeh   +8 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Effective Extracellular Volume Fraction Determined by Equilibrium Contrast-Enhanced CT for Differentiating Autoimmune Pancreatitis from Pancreatic Ductal Adenocarcinoma

open access: yesDiagnostics
Background/Objectives: The aim of this study was to determine whether extracellular volume (ECV) fraction as determined by contrast-enhanced computed tomography (CECT) can help distinguish between autoimmune pancreatitis (AIP) and pancreatic ductal ...
Akihiko Kanki   +8 more
doaj   +1 more source

Determination of Extracellular Space in Amphibian Muscle [PDF]

open access: yesThe Journal of General Physiology, 1967
The volumes of distribution of inulin and dextran in the sartorius, stomach, and cardiac muscle of the frog agree rather closely. That these spaces represent the volume of extracellular water is supported by the observation that efflux of sucrose can be divided into a fast and a slow phase and that the fast-moving fraction corresponds closely with ...
openaire   +2 more sources

Electrodiffusive model for astrocytic and neuronal ion concentration dynamics. [PDF]

open access: yesPLoS Computational Biology, 2013
The cable equation is a proper framework for modeling electrical neural signalling that takes place at a timescale at which the ionic concentrations vary little.
Geir Halnes   +4 more
doaj   +1 more source

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