Results 51 to 60 of about 360,385 (255)

A Space‐Time Conversion Vehicle for Programmed Multi‐Drugs Delivery into Pancreatic Tumor to Overcome Matrix and Reflux Barriers

Advanced Science, 2022
The numerous biological barriers, which limit pharmacotherapy of pancreatic carcinoma, including inadequate drug accumulation in the tumor environment, a dense extracellular matrix (ECM) and efficient drug‐efflux mechanisms, illustrate the requirement of
Taotao Huo, Xiaoyi Zhang, Min Qian, Huifang Nie, Dong Liang, Chenteng Lin, Yafeng Yang, Wei Guo, Ulrich Lächelt, Rongqin Huang   +9 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A three-dimensional mathematical model for the signal propagation on a neuron’s membrane.

Frontiers in Computational Neuroscience, 2015
In order to be able to examine the extracellular potential's influence on network activity and to better understand dipole properties of the extracellular potential, we present and analyze a three-dimensional formulation of the cable equation which ...
Konstantinos eXylouris, Gabriel eWittum
doaj   +1 more source

Extracellular space in some isolated tissues [PDF]

The Journal of Physiology, 1974
1. The spaces occupied by isotopically labelled inulin, polyethylene glycol, mol. wt. 4000 (PEG 4000), polyethylene glycol, mol. wt. 1000 (PEG 1000) and sucrose in metabolizing mammalian kidney and liver slices and in toad bladder epithelial cell preparations incubated in vitro have been examined.2.
D J, McIver, A D, Macknight
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Epithelial sodium channels (ENaC) produce extracellular positive DC potentials in the retinal neuroepithelium

Data in Brief, 2016
Positive DC (direct current) potentials were measured in the extracellular space in the retinal neuroepithelium of chick embryos. The positive DC potential was suppressed by amiloride, a blocker for epithelial Na+ channels (ENaC).
Masayuki Yamashita
doaj   +1 more source

Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity

Journal of Parkinson’s Disease, 2022
Background: Various cellular pathways have been implicated in the transfer of disease-related proteins between cells, contributing to disease progression and neurodegeneration. However, the overall effects of protein transfer are still unclear. Objective:
Inês C. Brás, Mohammad H. Khani, Eftychia Vasili, Wiebke Möbius, Dietmar Riedel, Iwan Parfentev, Ellen Gerhardt, Christiane Fahlbusch, Henning Urlaub, Markus Zweckstetter, Tim Gollisch, Tiago F. Outeiro   +11 more
doaj   +1 more source

Diffusion in the extracellular space in brain and tumors [PDF]

Physical Biology, 2013
Diffusion of solutes and macromolecules in the extracellular space (ECS) in brain is important for non-synaptic intercellular communication, extracellular ionic buffering, and delivery of drugs and metabolites. Diffusion in tumor ECS is important for delivery of anti-tumor drugs.
openaire   +4 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Circadian rhythm and sleep-wake systems share the dynamic extracellular synaptic milieu

Neurobiology of Sleep and Circadian Rhythms, 2018
The mammalian circadian and sleep-wake systems are closely aligned through their coordinated regulation of daily activity patterns. Although they differ in their anatomical organization and physiological processes, they utilize overlapping regulatory ...
Joanna M. Cooper, Kathryn A. Halter, Rebecca A. Prosser   +2 more
doaj   +1 more source