Results 71 to 80 of about 4,618,222 (282)

Epithelial sodium channels (ENaC) produce extracellular positive DC potentials in the retinal neuroepithelium

Data in Brief, 2016
Positive DC (direct current) potentials were measured in the extracellular space in the retinal neuroepithelium of chick embryos. The positive DC potential was suppressed by amiloride, a blocker for epithelial Na+ channels (ENaC).
Masayuki Yamashita
doaj   +1 more source

Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling

Nature Communications, 2020
The nanoscale organisation of the brain extracellular space can be studied in vivo. Here, the authors investigate how it changes in response to α-synuclein pathology, and identify interactions between microglia and the extracellular matrix.
Federico N. Soria, Chiara Paviolo, Evelyne Doudnikoff, Marie-Laure Arotcarena, Antony Lee, Noémie Danné, Amit Kumar Mandal, Philippe Gosset, Benjamin Dehay, Laurent Groc, Laurent Cognet, Erwan Bezard   +11 more
doaj   +1 more source

Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity

Journal of Parkinson’s Disease, 2022
Background: Various cellular pathways have been implicated in the transfer of disease-related proteins between cells, contributing to disease progression and neurodegeneration. However, the overall effects of protein transfer are still unclear. Objective:
Inês C. Brás, Mohammad H. Khani, Eftychia Vasili, Wiebke Möbius, Dietmar Riedel, Iwan Parfentev, Ellen Gerhardt, Christiane Fahlbusch, Henning Urlaub, Markus Zweckstetter, Tim Gollisch, Tiago F. Outeiro   +11 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Intracellular and extracellular tau

Frontiers in Neuroscience, 2010
In this short review is described the toxicity of modified intracellular tau and that of extracellular tau that could be released into the extracellular space after neuron death.
Jesus Avila, Jesus Avila
doaj   +1 more source

Modeling Extracellular Field Potentials and the Frequency-Filtering Properties of Extracellular Space [PDF]

Biophysical Journal, 2004
Extracellular local field potentials (LFP) are usually modeled as arising from a set of current sources embedded in a homogeneous extracellular medium. Although this formalism can successfully model several properties of LFPs, it does not account for their frequency-dependent attenuation with distance, a property essential to correctly model ...
Bédard, Claude, Kröger, Helmut, Destexhe, Alain   +2 more
openaire   +3 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The neuroglial potassium cycle during neurotransmission: role of Kir4.1 channels. [PDF]

PLoS Computational Biology, 2015
Neuronal excitability relies on inward sodium and outward potassium fluxes during action potentials. To prevent neuronal hyperexcitability, potassium ions have to be taken up quickly.
Jérémie Sibille, Khanh Dao Duc, David Holcman, Nathalie Rouach   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

ALS-like pathology diminishes swelling of spinal astrocytes in the SOD1 animal model

Frontiers in Cellular Neuroscience
Astrocytes are crucial for the functioning of the nervous system as they maintain the ion homeostasis via volume regulation. Pathological states, such as amyotrophic lateral sclerosis (ALS), affect astrocytes and might even cause a loss of such functions.
Tereza Filipi, Tereza Filipi, Jana Tureckova, Ondrej Vanatko, Ondrej Vanatko, Martina Chmelova, Monika Kubiskova, Monika Kubiskova, Natalia Sirotova, Natalia Sirotova, Stanislava Matejkova, Lydia Vargova, Miroslava Anderova   +12 more
doaj   +1 more source