Results 31 to 40 of about 8,377,419 (215)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Myocardial fibrosis in primary aldosteronism

Frontiers in Endocrinology
ObjectiveWe investigated myocardial fibrosis in relation to clinical and biochemical characteristics and the metabolomics in patients with primary aldosteronism.MethodsOur study included 54 patients with primary aldosteronism.
Yi-Lin Chen, Chi-Hua Chen, Xiao-Fei Ye, Jian-Zhong Xu, Li-Min Zhu, Ting-Yan Xu, Yan Li, Ji-Guang Wang   +7 more
doaj   +1 more source

Hyponatremia in peritoneal dialysis patients

Bulletin de la Dialyse à Domicile, 2022
Hyponatremia is the most common disorder of body fluid and electrolyte balance encountered in clinical practice, and also in peritoneal dialysis (PD) population.
Maxime Taghavi, Lucas Jacobs, Max Dratwa, Joelle Nortier   +3 more
doaj   +1 more source

Brain endothelium-derived extracellular vesicles containing amyloid-beta induce mitochondrial alterations in neural progenitor cells

, 2022
Aim: Elevated brain deposits of amyloid beta (Aβ40) contribute to neuropathology and cognitive dysfunction in Alzheimer’s disease (AD). However, the role of the blood-brain barrier (BBB) as an interface for the transfer of Aβ40 from the periphery into ...
Kowalczyk, Jennifer M, Louis, Kelssey D Pierre, Daftari, Manav T, Dykxhoorn, Derek M, Daftari, Manav T., Colbert, Brett M., Toborek, Michal, Kowalczyk, Jennifer M., András, Ibolya E., Dykxhoorn, Derek M., Colbert, Brett M, Torices, Silvia, Pierre Louis, Kelssey D., Osborne, Olivia M, András, Ibolya E, Naranjo, Oandy, Osborne, Olivia M.   +16 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Role of the Extracellular Volume of the Infarction Zone and the Remote Myocardium in Predicting Systolic Dysfunction After the First Myocardial Infarction

Diagnostics
Background/Objectives: This study aimed to evaluate the prognostic role of the extracellular volume (ECV) assessed by cardiac magnetic resonance imaging (MRI) in relation to systolic dysfunction and unfavorable remodeling of the left ventricular (LV) at ...
Valentin Oleynikov, Lyudmila Salyamova, Alexander Vdovkin, Natalia Donetskaya, Irina Avdeeva, Inna Babkina, Elena Averyanova   +6 more
doaj   +1 more source

MECHANISMS FOR THE FORMATION MYOCARDIAL FIBROSIS IN NORM AND IN CERTAIN CARDIOVASCULAR DISEASES, HOW TO DIAGNOSE IT

Медицинский совет, 2017
The review summarizes current knowledge regarding the origins and role of myocardial fibrosis formation, including the effects of humoral and cellular components.
S. V. Miklishanskaya, N. A. Mazur, N. V. Shestakova   +2 more
doaj   +1 more source

Focal and diffuse myocardial fibrosis both contribute to regional hypoperfusion assessed by post-processing quantitative-perfusion MRI techniques

Frontiers in Cardiovascular Medicine, 2023
IntroductionIndications for stress-cardiovascular magnetic resonance imaging (CMR) to assess myocardial ischemia and viability are growing. First pass perfusion and late gadolinium enhancement (LGE) have limited value in balanced ischemia and diffuse ...
Jeremy Weiner, Corinna Heinisch, Salome Oeri, Tomasz Kujawski, Zsolt Szucs-Farkas, Zsolt Szucs-Farkas, Rainer Zbinden, Dominik P. Guensch, Dominik P. Guensch, Kady Fischer   +9 more
doaj   +1 more source

Modeling cell movement in anisotropic and heterogeneous network tissues [PDF]

, 2007
Cell motion and interaction with the extracellular matrix is studied deriving a kinetic model and considering its diffusive limit. The model takes into account of chemotactic and haptotactic effects, and obtains friction as a result of the interactions ...
A. Chauviere, null null, T. Hillen, Preziosi, Luigi, L. Preziosi, Chauviere, A., Hillen, T.   +6 more
core   +1 more source