Results 81 to 90 of about 8,377,419 (215)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Systematic Review and Meta-Analysis of Cardiac MRI T1 and ECV Measurements in Pre-Heart Failure Populations

Hearts
Background/Objectives: Heart failure (HF) often develops from a prolonged asymptomatic phase where early detection could prevent progression. Pre-heart failure (pre-HF) populations—those with risk factors (Stage A) or subclinical myocardial changes ...
Robert S. Doyle, Ross Walsh, Jamie Walsh, Hugo C. Temperley, John McCormick, Gerard Giblin   +5 more
doaj   +1 more source

An ex vivo model of interactions between extracellular vesicles and peripheral mononuclear blood cells in whole blood [PDF]

, 2023
Extracellular vesicles (EVs) can be loaded with therapeutic cargo and engineered for retention by specific body sites; therefore, they have great potential for targeted delivery of biomolecules to treat diseases.
Carlson, Bess, Vazquez, Samuel, Witwer, Kenneth W, Izzi, Jessica M, Maxwell, Amanda, Castell, Natalie, Queen, Suzanne E, Rodriguez, Blanca V, Shirk, Erin N, Plunkard, Jessica, Gololobova, Olesia, Driedonks, Tom A P, Wen, Yi   +12 more
core  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Extracellular Volume Fraction Analysis on Cardiac Computed Tomography Is Useful for Predicting the Prognosis of Hypertrophic Cardiomyopathy

Journal of Cardiovascular Development and Disease
Extracellular volume fraction (ECV) analysis on computed tomography (CT) is now available. The purpose of this study was to assess the usefulness of CT-derived ECV analysis for predicting outcomes in patients with hypertrophic cardiomyopathy (HCM).
Shuhei Aoki, Hiroyuki Takaoka, Tomonori Kanaeda, Kazunari Asada, Joji Ota, Yoshitada Noguchi, Moe Matsumoto, Yusei Nishikawa, Katsuya Suzuki, Satomi Yashima, Makiko Kinoshita, Noriko Suzuki-Eguchi, Haruka Sasaki, Kohei Takahashi, Yoshihito Ozawa, Yosuke Inaba, Yoshio Kobayashi   +16 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Extracellular vesicles from microalgae

, 2021
The invention relates to extracellular vesicles derived from native, photosynthetic, non-fermenting microalgae, to a method of isolating extracellular vesicles from native, photosynthetic, non-fermenting microalgae by growth, centrifugation and ...
Gabriella Pocsfalvi, Nicolas Touzet, Mauro Manno, Antonella Bongiovanni   +3 more
core  

Effect of cytostatic drug presence on extracellular polymeric substances formation in municipal wastewater treated by membrane bioreactor [PDF]

, 2010
The effect of the cyclophosphamide and its mean metabolites on extracellular polymeric substances (EPS) formation was investigated. Two lab-scale membrane bioreactors were followed in parallel (one with the cytostatic drugs, the second without ...
Delgado, L.F., Avella, Catalina, Delgado, Luis Fernando, Avella, A.C., Görner, Tatiana, Albasi, Claire, de Donato, Ph., Galmiche, M., Görner, T., De Donato, Philippe   +9 more
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Development and Validation of Imaging‐Free Myocardial Fibrosis Prediction Models, Association with Outcomes, and Sample Size Estimation for Phase 3 Trials

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Phase 3 trials testing whether pharmacologic interventions targeting myocardial fibrosis improve outcomes require myocardial fibrosis measurement that does not rely on tomographic imaging with intravenous contrast.
Nicholas Black, Joshua Bradley, Gavin Lewis, Jakub Lagan, Christopher Orsborne, Fardad Soltani, John P. Farrant, Theresa McDonagh, Matthias Schmitt, João L. Cavalcante, Martin Ugander, Javed Butler, Mark C. Petrie, Christopher A. Miller, Erik B. Schelbert   +14 more
doaj   +1 more source