Results 131 to 140 of about 2,322,250 (249)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

SETLr: the semantic extract, transform, and load-r

open access: yes, 2018
Semantic Extract, Transform, and Load-er (SETLr) is a flexible, scalable tool for providing semantic interpretations to tabular, XML, and JSON-based data from local or web files.
McCusker, Jamie   +4 more
core  

Extract from field notes of J. Mathewson

open access: yes, 2008
An extract from Jeffery Mathewson's field notes of a survey made in September 1795. (It appears to be a resurvey of a section of the Ohio Company's grant.
Mathewson, Jeffery, 1761-1833
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Pond's extract, inflammations and hemorrhages

open access: yes
This apothecary card for Pond's Extract displays an illustration of a small boy at the top of the street lamp putting out the flame.
Pond’s Extract Company
core  

They won't kick against Pond's Extract

open access: yes, 2016
Trade card advertising Pond's Extract, a remedy prepared by the Pond's Extract Co., New York, N.Y. This card has an 1894 copyright date.

core  

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Pond's Extract heals all bruises, wounds, lameness and sprains

open access: yes, 2017
Trade card/ink blotter advertising Pond's Extract, a remedy prepared by Pond's Extract Co., New York, N ...

core  

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