Results 41 to 50 of about 3,634,641 (304)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Rapid exploration of anti-MRSA components from plants of Salvia

Natural Products and Bioprospecting
Plants of Salvia are frequently used for treatment infections of boils and sores in Traditional Chinese medicine, which might inhibit microbial. In this work, the chemical constituents of the effective fractions were analyzed using UPLC-Q-TOF–MS, and ...
Huan Huang, Zhao-Jie Wang, Li-Yu Bai, Yue-Ming Jiang, Yan-Yan Zhu, Yun-Li Zhao, Xiao-Dong Luo   +6 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Dietary ellagic acid inhibiting gastrointestinal pathogens by modulation of microbiome-metabolite-immune axis

Natural Products and Bioprospecting
Antibiotic-induced depletion of the gut microbiota facilitated the colonization of vancomycin-resistant Enterococci (VRE) in the gastrointestinal tract, and then increased patients' susceptibility to secondary infections.
Li-Na Mei, Jia-Shan Shen, Yu Duan, Zhuo-Qi Shi, Hui-Zhen Peng, Xiao-Dong Luo   +5 more
doaj   +1 more source

Novel sesquiterpenes and polyketides from the fungi Corynespora sp. YG-11 and Penicillium rubens YG-2 promote tobacco growth and enhance its stress resistance

Industrial Crops and Products
The deterioration of tobacco (Nicotiana tabacum L.) quality and yield is caused by abiotic stress (temperature, salt, heavy metals, etc.) and biotic stress (plant pathogens).
Jing Sun, Chuanmei Yi, Xuechan Yang, Fangyan Li, Xu Zheng, Zihao Xue, Yabin Yang, Zhongtao Ding, Xueqiong Yang   +8 more
doaj   +1 more source

Paracetamol extraction tablets: a green technique for teaching of pharmaceutical chemistry

Revista Brasileira de Ensino de Ciência e Tecnologia, 2020
This work presents the evaluation of the chemical vegetable for the extraction of the active ingredient of paracetamol 500 mg tablets, with optimization of the process through the holistic metrics of Green Chemistry. The previous analysis, indicated as a
Juliana Aparecida Bolzan, Sandra Inês Adams Angnes Gomes, Marilei Casturina Mendes Sandri   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Luffa–Ni/Al layered double hydroxide bio-nanocomposite for efficient ibuprofen removal from aqueous solution: Kinetic, equilibrium, thermodynamic studies and GEP modeling

Heliyon
Luffa is a robust, renewable biomaterial known for its low mass, high specific strength, and non-toxicity, making it ideal for composite development.
Soheil Tavassoli, Afsaneh Mollahosseini, Saeed Damiri, Mehrshad Samadi   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source