Results 61 to 70 of about 2,223 (231)

A clinicopathological analysis of forkhead box A1 (FOXA1) and estrogen receptor alpha expression in extramammary Paget’s disease

Fujita Medical Journal, 2023
Objectives: Extramammary Paget’s disease (EMPD) is a neoplastic skin disease of unknown etiology. EMPD is frequently associated with forkhead box A1 (FOXA1) expression, which correlates with the expression of estrogen receptor alpha (ER). FOXA1 regulates
Chiho Sumitomo, Yohei Iwata, Masaru Arima, Kazumitsu Sugiura   +3 more
doaj   +1 more source

Vulvar Paget disease secondary to high-grade urothelial carcinoma with underlying massive vascular embolization and cervical involvement: case report of unusual presentation

Diagnostic Pathology, 2019
Background Vulvar extramammary Paget disease is a rare chronic condition, that presents with non-specific symptoms such as pruritus and eczematous lesions. Because most of these lesions are noninvasive, the distinction between primary and secondary Paget
Walquiria Quida Salles Pereira Primo, Guttenberg Rodrigues Pereira Primo, Dunya Bachour Basilio, Karime Kalil Machado, Jesus Paula Carvalho, Filomena M. Carvalho   +5 more
doaj   +1 more source

A clinicopathological study of perianal paget disease: A single center-based cohort study and literature review

Dermatologica Sinica, 2022
Background: Perianal Paget disease (PPD), an uncommon extramammary Paget disease, is characterized by intraepidermal pagetoid spread of atypical Paget cells in the perianal skin. PPDs can be primary or secondary.
Ping-Chen Hou, Chaw-Ning Lee, Tak-Wah Wong, Tzu-Chien Hsu, Cheng-Lin Wu, Julia Yu-Yun Lee   +5 more
doaj   +1 more source

Perianal Paget Disease: Different Entities With the Same Name [PDF]

, 2021
Extramammary Paget disease (EMPD) is a rare form of cancer that involves skin areas rich in apocrine glands. The common sites of occurrence include the vulva, perianal region, perineum, and axilla.
Presa-Fernandes, José M, Santos, Marisa D., Silva, Donzília Sousa, Soares, Filomena   +3 more
core   +1 more source

Beyond the Ordinary: A Surgical Approach to Perianal Paget Disease

Journal of Coloproctology
Perianal Paget Disease (PPD) is a rare form of extramammary Paget disease characterized by erythematous or eczematous plaques in the perianal region. Its rarity and resemblance to benign skin conditions often result in delayed diagnosis.
Rita Ribeiro Dias, André Gonçalves, Joana Costa, Pedro Organista Machado, Eliane Jaconiano, Daniela Marinheiro Silva, Miguel Machado, Carolina Leal, Silvestre Carneiro   +8 more
doaj   +1 more source

Dermatologic Features of Endocrine Tumor Syndromes—Systematic Review and Meta‐Analysis

International Journal of Dermatology, EarlyView.
ABSTRACT Endocrine tumor syndromes, including multiple endocrine neoplasia types 1, 2A, and 2B (MEN1, MEN2A, MEN2B), Carney complex (CNC), and PTEN hamartoma tumor syndrome (PHTS), are hereditary conditions characterized by multisystem tumor development.
Sára Pálla, Zseraldin Metyovinyi, Fanni Adél Meznerics, Arash Mirzahosseini, Judit Tőke, Miklós Tóth, Henriett Butz, Attila Patócs, Márta Medvecz   +8 more
wiley   +1 more source

Glucocorticoid Receptor Activation Reprograms NK Cells to Drive AREG‐Mediated Immunosuppression: A Pan‐Cancer Role for AREG

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei, Guirong Liang, Rui zeng, Yuancheng Li, Anlan Hong, Hongsheng Wang, Suying Feng, Yan Wang, Yetao Wang   +8 more
wiley   +1 more source

Single‐Center Epidemiological Analysis of Malignant Transformation With Skin Ulcers in Outpatients

International Wound Journal, Volume 23, Issue 1, January 2026.
ABSTRACT Investigate the epidemiological characteristics of outpatients initially diagnosed with skin ulcers who were ultimately confirmed to have cutaneous malignant tumours, and provide a diagnostic and therapeutic basis for the occurrence of secondary diseases in chronic wounds.
Yaoyao Kong, Haixia Wang, Nan Cao, Pengcheng Huai, Zhenzhen Wang, Chaoqi Zuo, Xueqing Wang, Yilei Wu, Yongxia Liu, Shengli Chen, Hong Liu, Guangliang Zhang   +11 more
wiley   +1 more source

First Case of Primary Breast Melanoma in Central America: Case Report and Literature Review

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Primary breast melanoma is an exceedingly rare neoplasm, accounting for < 0.5% of all malignant breast tumors. Its scarcity and highly variable clinical presentation often delay diagnosis and complicate management. We report the case of a 55‐year‐old woman with a primary non‐cutaneous melanoma of the right breast initially misdiagnosed as high‐
Ana García‐Urbina, Denis Espinoza‐Vásquez, Johanna Obregón‐Silva, Arlin Montoya Rodríguez   +3 more
wiley   +1 more source

Figure S8 from Unbiased Detection of Driver Mutations in Extramammary Paget Disease [PDF]

, 2023
Yoshihiro Ishida, Nobuyuki Kakiuchi, Kenichi Yoshida, Yoshikage Inoue, Hiroyuki Irie, Tatsuki R. Kataoka, Masahiro Hirata, Takeru Funakoshi, Shigeto Matsushita, Hiroo Hata, Hiroshi Uchi, Yuki Yamamoto, Yasuhiro Fujisawa, Taku Fujimura, Ryunosuke Saiki, Kengo Takeuchi, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Atsushi Otsuka, Satoru Miyano, Kenji Kabashima, Seishi Ogawa   +22 more
openalex   +1 more source