Results 71 to 80 of about 1,691 (202)

First Case of Primary Breast Melanoma in Central America: Case Report and Literature Review

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Primary breast melanoma is an exceedingly rare neoplasm, accounting for < 0.5% of all malignant breast tumors. Its scarcity and highly variable clinical presentation often delay diagnosis and complicate management. We report the case of a 55‐year‐old woman with a primary non‐cutaneous melanoma of the right breast initially misdiagnosed as high‐
Ana García‐Urbina, Denis Espinoza‐Vásquez, Johanna Obregón‐Silva, Arlin Montoya Rodríguez   +3 more
wiley   +1 more source

Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Merkel Cell Carcinoma 2025

The Journal of Dermatology, Volume 52, Issue 11, Page e954-e967, November 2025.
ABSTRACT Merkel cell carcinoma (MCC) is a highly malignant skin cancer characterized by high rates of recurrence and metastasis. Although rare, the incidence has noticeably increased in recent years. It is also known to be a highly immunogenic tumor, and the use of immune checkpoint inhibitors has begun for advanced cases.
Motoki Nakamura, Kotaro Nagase, Junji Kato, Masahito Yasuda, Natsuo Tomita, Tadahiro Kobayashi, Keitaro Fukuda, Akihiko Yuki, Hiroshi Uchi, Hiroshi Koga, Tomomitsu Miyagaki, Yasuhiro Nakamura   +11 more
wiley   +1 more source

An Evaluation of HER2 Expression Heterogeneity in Primary Tumors and Metastatic Lymph Nodes of Patients With Advanced Extramammary Paget's Disease: Prognostic and Therapeutic Implications

Cancer Medicine, Volume 14, Issue 19, October 2025.
ABSTRACT Background HER2 expression in primary versus metastatic tumors in advanced Extramammary Paget's Disease (EMPD) remains inadequately characterized. This investigation aimed to assess HER2 expression heterogeneity between primary tumors and metastatic lymph nodes (LNs) in patients with advanced EMPD and to assess the prognostic value of HER2 ...
Zhicheng Liu, Xingliang Tan, Zhiming Wu, Yi Tang, Qianghua Zhou, Wensu Wei, Cong Yang, Long Huang, Yanjun Wang, Kai Yao   +9 more
wiley   +1 more source

Serum Nectin‐4 as a Potential Prognostic Biomarker for Extramammary Paget Disease

Experimental Dermatology, Volume 34, Issue 10, October 2025.
ABSTRACT Nectin cell adhesion molecule 4 (Nectin‐4) is overexpressed in the tissue of extramammary Paget disease (EMPD), and its potential role as a circulating biomarker remains poorly explored. We therefore investigated serum levels of Nectin‐4 in EMPD patients and healthy controls by ELISA assay and analysed its clinical relevance.
Hiromichi Morita, Takuya Miyagawa, Kenta Oka, Okuto Iwasawa, Hinako Saito, Toko Mori, Hisao Kawashima, Jun Omatsu, Daisuke Yamada, Shinichi Sato   +9 more
wiley   +1 more source

Comprehensive management of vulvovaginal cancers

CA: A Cancer Journal for Clinicians, Volume 75, Issue 5, Page 410-435, September/October 2025.
Abstract Vulvar and vaginal cancers represent rare malignancies, with an incidence of 2.7 per 100,000 women for vulvar cancer, predominantly affecting women older than 60 years, although rising rates are observed in younger demographics. Approximately 90% of vulvar cancers are squamous cell carcinoma and frequently are associated with human ...
Angélica Nogueira‐Rodrigues, Maaike H. M. Oonk, Domenica Lorusso, Brian Slomovitz, Mario M. Leitão Jr, Glauco Baiocchi   +5 more
wiley   +1 more source

An Asymptomatic Lesion on the Penis

JEADV Clinical Practice, Volume 5, Issue 1, Page 309-311, March 2026.
Brandon Tan, Karen Cheung, Xin Liu, Alexis Daniel Lara Rivero   +3 more
wiley   +1 more source

Cancer of the vulva: 2025 update

International Journal of Gynecology &Obstetrics, Volume 171, Issue S1, Page 36-47, September 2025.
Abstract Vulvar cancer is an uncommon gynecological malignancy primarily affecting postmenopausal women. No specific screening exists and the most effective strategy to reduce the incidence of vulvar cancer is the opportune treatment of predisposing and preneoplastic lesions associated with its development.
Alexander B. Olawaiye, Mauricio A. Cuello, Sushil Beriwal, Linda J. Rogers   +3 more
wiley   +1 more source

Genital Psoriasis: Shining Light on This Hidden Disease

JEADV Clinical Practice, Volume 4, Issue 4, Page 719-731, September 2025.
Psoriasis occurring on skin of the genital and perigenital regions has specific diagnostic and treatment requirements due to the sensitivity and private nature of these areas. A multidisciplinary group of experts in the management of genital psoriasis, the Genital Psoriasis Wellness Consortium, convened to discuss the impact of genital psoriasis on ...
Jennifer Cather, Melodie Young, Muriel Boreham, Shehla Admani, Tina Bhutani, Erin Foster, Richard Fried, Melinda Gooderham, Jeannette Jakus, Sandra Johnson, Ryoichi Kamide, John Koo, Tiffany Mayo, Michael Payette, Caitriona Ryan, Lucinda Whitney, Krista Bohnert, Melissa Seal, Patrick Burnett, Diane Hanna   +19 more
wiley   +1 more source

Clinicopathologic evaluation of mammary Paget′s disease

Indian Journal of Dermatology, 2008
Mammary and extramammary Paget′s diseases are rare neoplasms of epidermis and mucosal epithelium. Due to their nonspecific and variable clinical view, they have differential diagnosis with eczema, melanoma, Bowen′s disease, etc. To the best
Meibodi Naser, Ghoyunlu Vahid, Javidi Zari, Nahidi Yalda   +3 more
doaj  

Improving imiquimod use in cervical high‐grade squamous intraepithelial lesions: A qualitative study

Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 9, Page 1712-1719, September 2025.
Adequate patient counselling on imiquimod treatment, including the possible application methods and potential side effects, along with optimal guidance during treatment, contributes to a better patient experience and reduces the likelihood of early discontinuation of treatment.
Caroline L. P. Muntinga, Helena C. J. Schellekens, Charlotte G. J. Penders, Hélène van Meir, Gatske M. Nieuwenhuyzen‐De Boer, Anna J. M. van de Sande, Heleen J. van Beekhuizen, Peggy J. de Vos Van Steenwijk, Ruud L. M. Bekkers, Edith M. G. van Esch   +9 more
wiley   +1 more source