Results 41 to 50 of about 2,895 (221)

Progressive Paraparesis due to Extramedullary Haematopoiesis in Thalassaemia Intermedia Treated Successfully with Radiotherapy: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Extramedullary Haematopoiesis (EMH), a rare complication of Thalassaemia Intermedia (TI), can present with pressure symptoms including Spinal Cord Compression (SCC) and can be treated using surgery, radiotherapy, hypertransfusion, or hydroxyurea. Hereby,
Bithi Pal, Debottam Barman, Bodhiswatta Dutta   +2 more
doaj   +1 more source

Understanding a mass in the paraspinal region: an anatomical approach

Insights into Imaging, 2023
The paraspinal region encompasses all tissues around the spine. The regional anatomy is complex and includes the paraspinal muscles, spinal nerves, sympathetic chains, Batson’s venous plexus and a rich arterial network.
Maud Creze, Jessica Ghaouche, Gilles Missenard, Thierry Lazure, Guillaume Cluzel, Matthieu Devilder, Sylvain Briand, Marc Soubeyrand, Olivier Meyrignac, Robert-Yves Carlier, Charles Court, Charlie Bouthors   +11 more
doaj   +1 more source

Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites [PDF]

, 2017
A 43-year-old man had a peritoneovenous shunt inserted for the treatment of chylous ascites secondary to myelofibrosis. Despite being on anticoagulation for superior mesenteric vein thrombosis, he developed shunt dysfunction within two weeks of insertion.
D Hariharan, DN Lobo, EA Wilkes, GP Aithal, Leggio L, Moskovitz M, Nitta H, SJ Travis, Smadja C, White MA   +9 more
core   +2 more sources

Tie2 Expressing Monocytes in the Spleen of Patients with Primary Myelofibrosis. [PDF]

PLoS ONE, 2016
Primary myelofibrosis (PMF) is a Philadelphia-negative (Ph-) myeloproliferative disorder, showing abnormal CD34+ progenitor cell trafficking, splenomegaly, marrow fibrosis leading to extensive extramedullary haematopoiesis, and abnormal neoangiogenesis ...
Rita Campanelli, Gabriela Fois, Paolo Catarsi, Valentina Poletto, Laura Villani, Benedetta Gaia Erba, Luigi Maddaluno, Basilio Jemos, Silvia Salmoiraghi, Paola Guglielmelli, Vittorio Abbonante, Christian Andrea Di Buduo, Alessandra Balduini, Alessandra Iurlo, Giovanni Barosi, Vittorio Rosti, Margherita Massa, AGIMM Investigators   +17 more
doaj   +1 more source

Toxicological characterisation of two novel selective aryl hydrocarbon receptor modulators in Sprague-Dawley rats [PDF]

, 2017
The aryl hydrocarbon receptor (AHR) mediates the toxicity of dioxins, but also plays important physiological roles. Selective AHR modulators, which elicit some effects imparted by this receptor without causing the marked toxicity of dioxins, are ...
Esteban, Javier, Håkansson, Helen, Linden, Jere, Mahiout, Selma, Pettersson, Lars, Pohjanvirta, Raimo, Sanchez-Perez, Ismael, Sankari, Satu   +7 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

The bone marrow microenvironment – Home of the leukemic blasts [PDF]

, 2017
Acute Myeloid Leukaemia (AML) is a genetically, biologically and clinically heterogeneous set of diseases, which are characterised by an increased growth of abnormal myeloid progenitor cells within the bone marrow (BM).
Bowles, Kristian M, Gnaneswaran, Bruno, Rushworth, Stuart A, Shafat, Manar S   +3 more
core   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Cord Compression by Extramedullary Hematopoiesis in Polycythemia Vera [PDF]

, 2012
A 73-year-old male with polycythemia vera and a history of prostate cancer presents to an outside hospital complaining of back pain of two months duration.
Martinez, Jose, Reale, Lisa, Zrada, Steve   +2 more
core   +1 more source