Results 41 to 50 of about 60,697 (200)

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Risk Factors of Childhood Extrapulmonary Tuberculosis Compared to Pulmonary Tuberculosis in Bangladesh: A Hospital-based Study

Preventive Medicine: Research & Reviews
Introduction: Childhood tuberculosis (TB) is one of the common causes of child mortality and morbidity in Bangladesh. The study aimed to assess the risk factors of extrapulmonary TB (EPTB) and pulmonary TB (PTB) in children and compare those with PTB ...
Rahana Pervin, M. Atiqul Haque, Tanjela Bushra, Syeda Afroz, Sudipta Das, Rajan Talukder, Saleha S. Asha, Shahana Sultana, Khandakar Fatema, Md. Maruf Haque Khan   +9 more
doaj   +1 more source

Evaluation of Clinical and Laboratory Characteristics of Children with Pulmonary and Extrapulmonary Tuberculosis

Medicina, 2019
Background and objective: Tuberculosis (TB) is an important public health problem in both developing and developed countries. Childhood TB is also an important epidemiological indicator in terms of forming the future TB pool.
Deniz Aygun, Necla Akcakaya, Haluk Cokugras, Yıldız Camcıoglu   +3 more
doaj   +1 more source

What Works When Treating Granulomatous Disease in Genetically Undefined CVID? A Systematic Review

Frontiers in Immunology, 2020
BackgroundGranulomatous disease is reported in at least 8–20% of patients with common variable immunodeficiency (CVID). Granulomatous disease mainly affects the lungs, and is associated with significantly higher morbidity and mortality.
Astrid C. van Stigt, Astrid C. van Stigt, Astrid C. van Stigt, Willem A. Dik, Willem A. Dik, Lieke S. J. Kamphuis, Lieke S. J. Kamphuis, Bas M. Smits, Joris M. van Montfrans, P. Martin van Hagen, P. Martin van Hagen, P. Martin van Hagen, Virgil A. S. H. Dalm, Virgil A. S. H. Dalm, Virgil A. S. H. Dalm, Hanna IJspeert, Hanna IJspeert   +16 more
doaj   +1 more source

Small Airways Dysfunction and Remission in Adults With Asthma: A Longitudinal Exploratory Analysis of the AssessmenT of smalL Airways involvemeNT In aSthma (ATLANTIS) Study

Allergy, EarlyView.
We conducted a post hoc analysis of ATLANTIS, a multinational prospective study including 684 adults with asthma. Fewer small airway symptoms and lower disease activity are independently associated with asthma remission. Replicated airway transcriptomic signatures show increased IL‐4/13 signalling and reduced coagulation pathways across the ATLANTIS ...
Akshi Kumar, Rory Chan, Nazanin Zounemat‐Kermani, Eleanor Quek, Ian M. Adcock, Bianca Beghe, Christopher Brightling, Dave Singh, Janwillem Kocks, Alberto Papi, Klaus F. Rabe, Ulrica Scaffidi‐Argentina, Maarten van den Berge, Monica Kraft, Salman Siddiqui   +14 more
wiley   +1 more source

Common and Rare Radiological Findings of Pulmonary and Thoracic Hydatid Cysts

Eurasian Journal of Medicine
Clinical findings of pulmonary hydatid cysts (HCs) are generally nonspecific, with lower serological positivity than hepatic cases; therefore, radiological imaging serves as the primary diagnostic tool.
Yener Aydın, Fatma Durmaz, Ali Bilal Ulaş, Mesut Özgökçe   +3 more
doaj   +1 more source

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

Acta Paediatrica, EarlyView.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source

Concurrent peritoneal and pleural tuberculosis in an adult: A case report and literature review [PDF]

Caspian Journal of Internal Medicine
Background: The simultaneous involvement of the pleura and peritoneum with tuberculosis in the absence of pulmonary foci is an uncommon condition that may lead physicians to misdiagnose.
Elham Barahimi, Zahra Ghaeini Hesarooeyeh, Ayoub Basham, Mohadeseh Karimi, Behnoush Heidari   +4 more
doaj  

5-Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan as a Potential Standard for Second-line Therapy in Extrapulmonary Neuroendocrine Carcinomas

Journal of Cancer Research and Practice
Background: Neuroendocrine carcinomas (NECs) are classified by the World Health Organization as poorly differentiated, aggressive Grade 3 tumors with high proliferative indices and frequent lung involvement.
I-Wei Ho, Nai-Jung Chiang, Jiun-I Lai, Peter Mu-Hsin Chang, San-Chi Chen, Yi-Ping Hung, Ming-Huang Chen   +6 more
doaj   +1 more source

The lung is more than an organ of gas exchange: immunocompetency, platelets and implications for drug discovery

British Journal of Pharmacology, EarlyView.
Abstract The lungs have for a long time been recognised as having pharmacological significance as a specific organ to modulate the pharmacokinetics of endogenous substances needed to maintain homeostasis. The lungs are therefore the site of action of certain drugs that act on these homeostatic processes, resulting in systemic effects on the ...
Simon C. Pitchford
wiley   +1 more source