Results 61 to 70 of about 86,947 (289)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Madogram and Asymptotic Independence among Maxima

Revstat Statistical Journal, 2014
A strong statistical research effort has been devoted in multivariate extreme value theory in order to assess the strength of dependence among extremes. This topic is particularly difficult in the case where block maxima are near independence.
Armelle Guillou , Philippe Naveau , Antoine Schorgen   +2 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Rotating black holes with equal-magnitude angular momenta in d=5 Einstein-Gauss-Bonnet theory

, 2010
We construct rotating black hole solutions in Einstein-Gauss-Bonnet theory in five spacetime dimensions. These black holes are asymptotically flat, and possess a regular horizon of spherical topology and two equal-magnitude angular momenta associated ...
A Anabalon, B Kleihaus, B Kleihaus, B Kleihaus, B Kleihaus, Burkhard Kleihaus, C Charmousis, C Garraffo, CG Callan Jr, D Astefanesei, D Astefanesei, D Astefanesei, D Astefanesei, D Astefanesei, D Kastor, D Lovelock, DG Boulware, DJ Gross, E Gravanis, Eugen Radu, GW Gibbons, H-C Kim, HK Kunduri, I Antoniadis, J Kunz, J Kunz, J Kunz, J Kunz, J Kunz, J Kunz, JD Brown, JT Wheeler, JT Wheeler, Jutta Kunz, K Goldstein, M Guica, P Kraus, R Gregory, R Monteiro, R Monteiro, R-G Cai, RB Mann, RB Mann, RB Mann, RC Myers, RC Myers, RC Myers, RM Wald, RR Metsaev, S Alexeyev, S Ferrara, SC Davis, SR Lau, SS Gubser, T Jacobson, T Kobayashi, T Torii, T Torii, U Ascher, U Ascher, V Balasubramanian, W Schönauer, Y Brihaye, Y Brihaye, Y Brihaye, Y Brihaye, Y Brihaye, Yves Brihaye   +67 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Shape dependence of mutual information in the OPE limit: linear responses

Journal of High Energy Physics, 2022
Mutual information serves as an important measure of correlation between subsystem components. In the framework of quantum field theories (QFTs) they have better regulated UV behavior than entanglement entropy, and thus provide more direct access to ...
Liangyu Chen, Huajia Wang
doaj   +1 more source

The max-plus Martin boundary [PDF]

, 2004
We develop an idempotent version of probabilistic potential theory. The goal is to describe the set of max-plus harmonic functions, which give the stationary solutions of deterministic optimal control problems with additive reward.
Akian, Marianne, Gaubert, Stephane, Walsh, Cormac   +2 more
core   +4 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source