Results 101 to 110 of about 2,763,716 (303)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Solution of Deformed Einstein Equations and Quantum Black Holes

Advances in High Energy Physics, 2016
Recently, one- and two-parameter deformed Einstein equations have been studied for extremal quantum black holes which have been proposed to obey deformed statistics by Strominger.
Emre Dil, Erdinç Kolay
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Black p-branes in heterotic string theory

Journal of High Energy Physics
Heterotic string theory has nonsupersymmetric branes whose existence is suggested by the cobordism conjecture. We numerically construct static, spherically symmetric, and asymptotically flat black brane solutions in ten-dimensional heterotic superstring ...
Masaki Fukuda, Shun K. Kobayashi, Kento Watanabe, Kazuya Yonekura   +3 more
doaj   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Inference for extremal conditional quantile models, with an application to market and birthweight risks [PDF]

Quantile regression is an increasingly important empirical tool in economics and other sciences for analyzing the impact of a set of regressors on the conditional distribution of an outcome. Extremal quantile regression, or quantile regression applied to
Victor Chernozhukov, Iván Fernández-Val   +1 more
core  

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Periodic boundary value problem for second order integro-ordinary differential equations with general kernel and Carathéodory nonlinearities

International Journal of Mathematics and Mathematical Sciences, 1995
We study the existence of solutions for the periodic boundary value problem for some second order integro-differential equations with a general kernel. Also we develop the monotone method to approximate the extremal solutions of the problem.
Juan J. Nieto
doaj   +1 more source

Idempotent structures in optimization [PDF]

, 2001
Consider the set A = R ∪ {+∞} with the binary operations o1 = max and o2 = + and denote by An the set of vectors v = (v1,...,vn) with entries in A. Let the generalised sum u o1 v of two vectors denote the vector with entries uj o1 vj , and the product
Kolokoltsov, V. N. (Vasiliĭ Nikitich)
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source