Results 81 to 90 of about 2,763,716 (303)
Perfect spline solutions of L∞ extremal problems by control methods [PDF]
, 1975 Methods of analyzing linear time-optimal control problems are adapted to the analysis of the extremal problem ∥L|0∥∞ = inf| ϵU∥L|∥∞; L is a linear nth order differential operator and U is a flat in the Sobolev space Wn,∞[a, b].
McClure, Donald E
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Charged black holes in non-linear Q-clouds with O(3) symmetry
Physics Letters B, 2020 We construct charged soliton solutions around spherical charged black holes with no angular momentum in asymptotically flat spacetime. These solutions are non-linear generalizations of charged scalar clouds, dubbed Q-clouds, and they do not contradict ...
Jeong-Pyong Hong +2 more
doaj +1 more source
Rare Events, Temporal Dependence and the Extremal Index [PDF]
AMS classifications: 60G70; 62G32;block maximum;exceedance;extremal index;failure set;mixing condition;M4 process;rare event;stationary ...
Segers, J.J.J.
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Electro-magnetic energy extraction from rotating black holes in AdS
Journal of High Energy Physics, 2020 Force-Free Electrodynamics for black holes in Anti de Sitter is considered. We present new, energy extracting solutions of Force-Free Electrodynamics in Anti de Sitter-Near Horizon Extremal Kerr and Super-Entropic Near Horizon Extremal Kerr geometries ...
Nele Callebaut +2 more
doaj +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
EXTREMAL DEPENDENCE IN EXCHANGE RATE MARKETS [PDF]
Exchange rate markets exhibit correlation in the short run, but the issue is whether such correlation lingers over long periods of time, and under extreme events (i.e., either large appreciations or depreciations).
Viviana Fernandez
core
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source