Results 71 to 80 of about 1,795 (267)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Some remarks on biharmonic elliptic problems with positive, increasing and convex nonlinearities

Electronic Journal of Differential Equations, 2005
We study the existence of positive solutions for a fourth order semilinear elliptic equation under Navier boundary conditions with positive, increasing and convex source term. Both bounded and unbounded solutions are considered. When compared with second
Filippo Gazzola, Elvise Berchio
doaj  

Smooth extremal horizons are the exception, not the rule

Journal of High Energy Physics
We show that the general charged, rotating black hole in five-dimensional Einstein-Maxwell theory has a singular extremal limit. Only the known analytic solutions with exactly zero charge or zero angular momenta have smooth extremal horizons.
Gary T. Horowitz, Jorge E. Santos
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Integral boundary value problems for second-order causal differential equations

Boundary Value Problems
This paper is concerned with second-order causal differential equations with Riemann–Stieltjes integral boundary conditions. To obtain sufficient conditions for the existence of extremal solutions for such problems, a novel comparison principle is first ...
Wenli Wang, Junyan Bao
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Black p-branes in heterotic string theory

Journal of High Energy Physics
Heterotic string theory has nonsupersymmetric branes whose existence is suggested by the cobordism conjecture. We numerically construct static, spherically symmetric, and asymptotically flat black brane solutions in ten-dimensional heterotic superstring ...
Masaki Fukuda, Shun K. Kobayashi, Kento Watanabe, Kazuya Yonekura   +3 more
doaj   +1 more source

Solution of Deformed Einstein Equations and Quantum Black Holes

Advances in High Energy Physics, 2016
Recently, one- and two-parameter deformed Einstein equations have been studied for extremal quantum black holes which have been proposed to obey deformed statistics by Strominger.
Emre Dil, Erdinç Kolay
doaj   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source